Produkte von AdipoGen Life Sciences
AdipoGen Life Sciences verbindet Immunologie und Metabolismus. Die AdipoGen-Zentrale befindet sich in San Diego, USA mit einem Produktionslabor in der Schweiz. Hoch qualifizierte Wissenschaftler*innen entwickeln dort neue Produkte für den Life Science-Markt in den Bereichen Krebs, Immunologie, Entzündung (der Experte im Bereich Inflammasom-Forschung), Metabolisches Syndrom (Diabetes, Fettleibigkeit), Stammzellen und Neurodegeneration. Der Schwerpunkt liegt auf innovativen und fortschrittlichen ELISA-Kits. Zusätzlich zu den Antikörper- und Protein-Einrichtungen besitzt AdipoGen auch chemische Laboratorien für die Entwicklung neuer und innovativer Biochemikalien.
Mehr Informationen unter: www.adipogen.com
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PARG Inhibitor PDD00017273
Artikelnummer: AG-CR1-3646-M001
White to off-white solid. Soluble in DMSO, methanol or acetonitrile. Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies, Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>,30µ,M)....
| Schlagworte: | PARG Inhibitor Compound 4,... |
| Anwendung: | PARG inhibitor |
| CAS | 1945950-21-9 |
| MW: | 514,6 D |
ab 72,00 €
Anti-Gasdermin D (mouse)
Artikelnummer: AG-25B-0036-C100
Inflammasomes are multimeric protein complexes that comprise a sensor (e.g. NLRP3), an adaptor (ASC/Pycard) and the procaspase-1. An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of...
| Schlagworte: | anti-Gasdermin D (mouse), pAb (IN110) |
| Anwendung: | WB, ELISA |
| Wirt: | Guinea pig |
| Spezies-Reaktivität: | mouse |
418,00 €
Anti-TRAIL-R1 (human), clone TR1.02
Artikelnummer: AG-20B-0027-C100
Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex...
| Schlagworte: | TRAIL Receptor 1, DR4, APO2, TNFRSF10A, CD261 |
| Anwendung: | FC, IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
396,00 €
Malformin C
Artikelnummer: AG-CN2-0107-M001
Peptide antibiotic, induces root curvature and malformation in plants, antibacterial, antimalarial and antitrypanosomal, disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents
| Schlagworte: | 5-L-Leucine-Malformin A, BRN 4896114, (-)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-] |
| Anwendung: | Apoptosis Inducer |
| CAS | 59926-78-2 |
| MW: | 529,7 D |
ab 132,00 €
Pam3Cys-Ser-(Lys)4 . 3HCl
Artikelnummer: AG-CP3-0003-M002
Synthetic. Selective agonist of TLR1/TLR2 complex. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Potent and effective immune adjuvant. Exerts strong local response,...
| Schlagworte: | Pam3CSK4, Pam3Cys-SKKKK, (S)-[2,3-Bis(palmitoyloxy)-(2- RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys 4-OH |
| Anwendung: | TLR1/TLR2 agonist |
| CAS | 112208-00-1 |
| MW: | 1619,7 D |
506,00 €
![alpha-Galactosylceramide Analog I (water soluble) [KBC-007]](https://www.biomol.com/media/image/64/ee/b7/AG-CR1-3608-C100_200x200.png "alpha-Galactosylceramide Analog I (water soluble) [KBC-007]")
alpha-Galactosylceramide Analog I (water soluble) [KBC-007]
Artikelnummer: AG-CR1-3608-C100
Synthetic, soluble analog of alpha-galactosylceramide (Prod. No. AG-CN2-0013). Immunostimulant. Potent stimulator of natural killer T (NKT) cells. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells.
| Schlagworte: | alpha-Gal-Cer Water Soluble Analog, alpha-Galactosylceramide Analog I, alpha-Gal-Cer Analog I |
| Anwendung: | Immunostimulant, CD1d ligand |
| CAS | 1037297-61-2 |
| MW: | 817,2 D |
ab 132,00 €
Wortmannin
Artikelnummer: AG-CN2-0023-M001
Isolated from Penicillium sp. Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of...
| Schlagworte: | KY 12420, BRN 0067676, NSC 627609, Antibiotic SL-2052 |
| Anwendung: | PI3 kinase inhibitor, Adipogenesis inhibitor, Angiogenesis inhibitor |
| CAS | 19545-26-7 |
| MW: | 428,4 D |
ab 44,00 €
Streptozotocin
Artikelnummer: AG-CN2-0046-G001
Antibiotic Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic beta-cells Mutagenic. Potent alkylating agent. Potent DNA methylating agent Nitric oxide (NO) donor. Vasorelaxant. Cytotoxic to cells that express GLUT2 glucose transporter....
| Schlagworte: | 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, Streptozocin, STZ, NSC 85998, Antibiotic U9889, Zanosar |
| Anwendung: | Alkylating agent |
| Wirt: | Synthetic |
| CAS | 18883-66-4 |
| MW: | 265,2 D |
ab 33,00 €
Dihydroartemisinin
Artikelnummer: AG-CN2-0468-G001
White solid. Soluble in DMSO or ethanol. Active metabolite of artemisinin, Anti-malaria (Plasmodium), Anti-schistosoma, Apoptosis inducer, Anti-cancer, Anti-inflammatory, Inhibits production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide...
| Schlagworte: | Dihydroqinghaosu, Artenimol |
| Anwendung: | Artemisinin metabolite, Antimalaria, Antischistosoma, Apoptosis inducer, Anticancer, Antiinflammatory |
| CAS | 71939-50-9 |
| MW: | 284,3 D |
ab 50,00 €
![K777 [K11777]](https://www.biomol.com/media/image/e7/bc/7c/AG-CR1-0158-M001_200x200.png "K777 [K11777]")
K777 [K11777]
Artikelnummer: AG-CR1-0158-M005
Solid. Soluble in DMSO. Insoluble in water. Potent, irreversible cysteine protease inhibitor, Broad-range cathepsin inhibitor (for all known cathepsins) useful for inflammasome inhibition. Inhibits cathepsins B, L, S, C, V, K and papain in cell-free assays. Inhibits cathepsin X as well, Suppresses particle-induced...
| Schlagworte: | K-777, K-11777, N-Pip-F-hF-VS Phenyl, N-Pip-phenylalanine-homophenylalanine-vinyl sulfone phenyl,... |
| Anwendung: | Potent irreversible cysteine protease inhibitor |
| CAS | 233277-99-1 |
| MW: | 574,7 D |
ab 55,00 €
GW501516
Artikelnummer: AG-CR1-3641-M025
White to off-white solid. Soluble in DMSO (30mg/ml), dimethylformamide (30mg/ml), ethanol (10mg/ml) or methanol (30mg/ml). Sparingly soluble in water. Potent and selective peroxisome proliferator-activated receptor (PPAR) delta agonist/activator with high affinity (Ki=1nM) and potency (EC50=1nM) for PPARdelta and...
| Schlagworte: | GSK-516, GW1516, Endurobol, 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic... |
| Anwendung: | PPARD agonist |
| CAS | 317318-70-0 |
| MW: | 453,5 D |
ab 33,00 €
COVID-19 Forschung
Auranofin
Artikelnummer: AG-CR1-3611-M025
White to off-white solid. Soluble in DMSO or 100% ethanol. Insoluble in water. Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway, Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5, Potent thioredoxin...
| Schlagworte: | 1-Thio-beta-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetra- acetate, NSC 321521, SKF 39162 |
| Anwendung: | Antiinflammatory agent |
| CAS | 34031-32-8 |
| MW: | 678,5 D |
ab 66,00 €