Produkte von TargetMol

TargetMol aus Boston (Massachusetts) wurde 2015 gegründet und ist ein Experte für Wirkstoffscreening in der Life Science-Community. Das Unternehmen bietet diverse Substanzbibliotheken, darunter FDA-zugelassene Bibliotheken, an und deckt ein breites Spektrum an niedermolekularen Verbindungen wie Inhibitoren und Agonisten sowie rekombinante Proteine und Naturstoffe ab. Die Produkte von TargetMol werden von Forschenden weltweit in Bereichen wie Krebsforschung, Neurobiologie, Inflammation, Immunologie oder Metabolismus eingesetzt.

Mehr Informationen unter: www.targetmol.com

Zu den Katalogen von TargetMol

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VEGFR-2-IN-18

Artikelnummer: TGM-T61561-100mg

Description: VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, exhibiting an IC50 value of 60 nM. This compound effectively induces cell apoptosis and demonstrates significant antitumor properties [1]. Target: Others

MW:

376.8 D

ab 1.440,00 €

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Vanin-1-IN-3

Artikelnummer: TGM-T61568-100mg

Description: Vanin-1-IN-3 (OMP-7) is a vanin-1 inhibitor with an IC50 of 0.038 µM [1]. Target: Others

MW:

377.36 D

ab 1.440,00 €

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Mt KARI-IN-1

Artikelnummer: TGM-T61569-100mg

Description: Mt KARI-IN-1 is a lead compound that demonstrates strong inhibitory activity towards Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 3.06 µM [1]. Target: Others

MW:

377.4 D

ab 1.440,00 €

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MtTMPK-IN-5

Artikelnummer: TGM-T61573-100mg

Description: MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 of 34 µM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, with an MIC of 12.5 µM. Given its potent...

MW:

377.44 D

ab 1.440,00 €

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PD-L1-IN-1

Artikelnummer: TGM-T61574-100mg

Description: PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9...

MW:

377.44 D

ab 815,00 €

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LasR-IN-2

Artikelnummer: TGM-T61581-100mg

Description: LasR-IN-2, a compound that inhibits the activity of LasR, forms hydrogen bonding with the TRY-56 residue. It finds application in the study of bacterial infection, neutropenia, severe burns, and chronic lung disease in cystic fibrosis (CF) [1]. Target: Others

MW:

377.82 D

ab 1.440,00 €

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CDK/HDAC-IN-1

Artikelnummer: TGM-T61583-100mg

Description: CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively. Target: Others

MW:

378.38 D

ab 1.440,00 €

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EGFR/HER2/DHFR-IN-1

Artikelnummer: TGM-T61596-100mg

Description: EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound targeting MCF-7 breast cancer cells, acting as a multi-inhibitor for EGFR/HER2 kinase and DHFR enzymes, with IC50 values of 0.153 µM, 0.108 µM, and 0.291 µM, respectively. It induces cell cycle arrest at the G1/S phase and...

MW:

379.23 D

ab 1.440,00 €

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TLR7/8 antagonist 2

Artikelnummer: TGM-T61601-100mg

Description: TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8 with IC50 values of 4.9 nM for TLR7 and 0.6 nM for TLR8, making it a promising candidate for treating and investigating autoimmune diseases like lupus erythematosus, which involves inappropriate activation of TLR7...

MW:

379.47 D

ab 1.440,00 €

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Anticancer agent 35

Artikelnummer: TGM-T61602-100mg

Description: Anticancer agent 35 (compound 10), a sulfonylurea derivative, is a potent anticancer agent that inhibits A549, A431, and PACA2 cell growth with IC50 values of 18.1 µg/mL, 4.0 µg/mL, and 18.9 µg/mL, respectively [1]. Target: Others

MW:

379.48 D

ab 1.440,00 €

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H3R antagonist 2

Artikelnummer: TGM-T61603-100mg

Description: H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor antagonist with inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B) with IC50 values of 180 nM, 880 nM, and 775 nM, respectively. With a Ki of 170 nM for hH3R, it demonstrates...

MW:

379.49 D

ab 1.440,00 €

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Hcyb1

Artikelnummer: TGM-T61617-100mg

Description: Hcyb1 is a potent and specific inhibitor of phosphodiesterase 2 (PDE2). It exhibits a high degree of selectivity for inhibiting PDE2A with an IC50 value of 0.57 µM. In addition, Hcyb1 displays over 250-fold selectivity against other recombinant members of the PDE family. Moreover, its pharmacological...

MW:

380.44 D

ab 867,00 €

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