Produkte von TargetMol

TargetMol aus Boston (Massachusetts) wurde 2015 gegründet und ist ein Experte für Wirkstoffscreening in der Life Science-Community. Das Unternehmen bietet diverse Substanzbibliotheken, darunter FDA-zugelassene Bibliotheken, an und deckt ein breites Spektrum an niedermolekularen Verbindungen wie Inhibitoren und Agonisten sowie rekombinante Proteine und Naturstoffe ab. Die Produkte von TargetMol werden von Forschenden weltweit in Bereichen wie Krebsforschung, Neurobiologie, Inflammation, Immunologie oder Metabolismus eingesetzt.

Mehr Informationen unter: www.targetmol.com

Zu den Katalogen von TargetMol

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VEGFR-2-IN-18

Artikelnummer: TGM-T61561-100mg

Description: VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, exhibiting an IC50 value of 60 nM. This compound effectively induces cell apoptosis and demonstrates significant antitumor properties [1]. Target: Others

MW:

376.8 D

ab 1.440,00 €

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Nrf2 activator-2

Artikelnummer: TGM-T61688-100mg

Description: Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 µM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces...

MW:

385.25 D

ab 932,00 €

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AZD 2066 hydrate

Artikelnummer: TGM-T61708-25mg

Description: AZD 2066 hydrate is a selective, orally active, brain-penetrant mGluR5 antagonist with antinociceptive effects [1]. Target: Others

MW:

386.33 D

ab 1.364,00 €

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AMS-17

Artikelnummer: TGM-T61709-100mg

Description: AMS-17 is a potent NLRP3 inhibitor that effectively suppresses microglia activation both in vitro and in vivo. Moreover, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-alpha, IL-1beta, and inducible nitric oxide synthase (iNOS), in N9 cells, making it a promising tool...

MW:

386.35 D

ab 1.440,00 €

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Trk-IN-8

Artikelnummer: TGM-T61712-100mg

Description: Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1]. Target: Others

MW:

386.36 D

ab 1.440,00 €

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COX-2-IN-13

Artikelnummer: TGM-T61714-100mg

Description: COX-2-IN-13 (compound 13e) is a highly potent and selective COX-2 inhibitor with an impressive IC50 value of 0.98 µM. It exhibits strong anti-inflammatory activity and has shown favorable results in in vivo acute toxicity studies [1]. Target: Others

MW:

386.42 D

ab 1.440,00 €

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Steroid sulfatase/17beta-HSD1-IN-1

Artikelnummer: TGM-T61716-100mg

Description: Steroid sulfatase/17beta-HSD1-IN-1 is a highly effective inhibitor of steroid sulfatase and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) activities, with an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating...

MW:

386.42 D

ab 1.440,00 €

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mPGES-1-IN-1

Artikelnummer: TGM-T61718-100mg

Description: MPGES-1, a promising therapeutic target for the next generation of anti-inflammatory drugs in treating inflammatory diseases, possesses an IC50 value of 0.03 µM for mPGES-1-IN-1. Target: Others

MW:

386.43 D

ab 1.440,00 €

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Pol I-IN-1

Artikelnummer: TGM-T61720-100mg

Description: Pol I-IN-1 is a potent inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, with an inhibition concentration (IC50) of 0.21 µM [1]. Target: Others

MW:

386.45 D

ab 1.440,00 €

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SS-RJW100

Artikelnummer: TGM-T61723-100mg

Description: SS-RJW100 is an enantiomer of RJW100, known as a racemic agonist that targets two nuclear receptors: liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). In vitro experiments reveal that SS-RJW100 promotes the recruitment of coregulator protein fragments and enhances the interaction with...

MW:

386.57 D

ab 1.440,00 €

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SB 258741 hydrochloride

Artikelnummer: TGM-T61724-100mg

Description: SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1]. Target: Others

MW:

386.98 D

ab 1.440,00 €

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