Produkte von TargetMol

TargetMol aus Boston (Massachusetts) wurde 2015 gegründet und ist ein Experte für Wirkstoffscreening in der Life Science-Community. Das Unternehmen bietet diverse Substanzbibliotheken, darunter FDA-zugelassene Bibliotheken, an und deckt ein breites Spektrum an niedermolekularen Verbindungen wie Inhibitoren und Agonisten sowie rekombinante Proteine und Naturstoffe ab. Die Produkte von TargetMol werden von Forschenden weltweit in Bereichen wie Krebsforschung, Neurobiologie, Inflammation, Immunologie oder Metabolismus eingesetzt.

Mehr Informationen unter: www.targetmol.com

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Avibactam sodium dihydrate

Artikelnummer: TGM-T60874-100mg

Description: Avibactam sodium (NXL-104) dihydrate inhibits CTX-M-15 and beta-lactamase TEM-1 with IC50 values of 5 nM and 8 nM, respectively, and is a reversible covalent inhibitor of non-beta-lactam beta-lactamase [1]. Target: Others

MW:

323.26 D

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5-Ph-IAA-AM

Artikelnummer: TGM-T60878-10mg

Description: 5-Ph-IAA-AM, an eggshell-permeable analog of 5-Ph-IAA, enhances protein degradation in laid embryos and can be used to reveal the roles of temporally controlled protein degradation in C. elegans embryogenesis and development [1]. Target: Others

MW:

323.34 D

ab 840,00 €

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MLKL-IN-1

Artikelnummer: TGM-T60885-100mg

Description: MLKL-IN-1, a covalent inhibitor of MLKL, has a dissociation constant (Kd) of 50 µM. Target: Others

MW:

324.37 D

ab 1.440,00 €

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NiCur

Artikelnummer: TGM-T60888-100mg

Description: NiCur blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur is a potent and selective inhibitor of CBP histone acetyltransferase (HAT) with an IC 50 value of 0.35 µ?. NiCur can be used to perform mechanistic studies without affecting target proteins expression [1]....

MW:

324.38 D

ab 585,00 €

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JAK-2/3-IN-3

Artikelnummer: TGM-T60895-100mg

Description: JAK-2-/3-IN-3 (compound ST4j) is a potent inhibitor of JAK2/3, with IC50 values of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. It inhibits JAK2 autophosphorylation, induces apoptosis in a time- and dose-dependent manner, and can be used in lymph-derived diseases and leukemia research [1]....

MW:

325.15 D

ab 1.440,00 €

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HER2-IN-11

Artikelnummer: TGM-T60896-100mg

Description: HER2-IN-11 is a psoralen derivative that induces apoptosis, exhibits light-activated cytotoxicity, and demonstrates anti-breast cancer activity [1]. Target: Others

MW:

325.27 D

ab 1.440,00 €

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HbF inducer-1

Artikelnummer: TGM-T60898-100mg

Description: HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable. Target: Others

MW:

325.36 D

ab 1.440,00 €

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IRAK4-IN-11

Artikelnummer: TGM-T60899-100mg

Description: IRAK4-IN-11 (compound 6) is a potent IRAK4 inhibitor with an IC50 of 0.008 µM, demonstrating cell pIRAK4 potencies with an IC50 of 0.19 µM [1]. Target: Others

MW:

325.37 D

ab 1.440,00 €

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Miaosporone A

Artikelnummer: TGM-T60906-100mg

Description: Miaosporone A is an angucyclic quinone which shows cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells. Miaosporone A has antibacterial activity against Mycobacterium tuberculosis and antimalarial activity against Plasmodium falciparum K1 with IC50 values of...

MW:

326.34 D

ab 1.440,00 €

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EGFR/HER2-IN-8

Artikelnummer: TGM-T60938-100mg

Description: EGFR/HER2-IN-8 (compound 34) is an inhibitor of EGFR, HER2, and DHFR with IC50 values of 0.45 µM, 0.244 µM, and 5.669 µM, respectively. It demonstrates anticancer activity against several cancer cell lines, exhibiting a high safety profile and selectivity indices, making it useful for cancer research...

MW:

328.39 D

ab 1.440,00 €

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ChE/Abeta1-42-IN-1

Artikelnummer: TGM-T60940-100mg

Description: ChE/Abeta1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Abeta1-42 with excellent BBB permeability, exhibiting IC50 values of 0.062 µM for AChE, 0.767 µM for BuChE, and 1.227 µM for Abeta1-42 aggregation. ChE/Abeta1-42-IN-1 is a potent multi-targeted anti-Alzheimer's disease agent...

MW:

328.41 D

ab 1.440,00 €

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LSD1-IN-15

Artikelnummer: TGM-T60941-100mg

Description: LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor that inhibits LSD1-CoREST, MAO-A, and MAO-B with IC50 values of 0.149, 0.028, and 0.327 µM, respectively. LSD1-IN-15 induces cell growth arrest in LNCaP cells of prostate cancer, with an IC50 value of 9.9 µM [1]. Target: Others

MW:

328.41 D

ab 1.440,00 €

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