Produkte von TargetMol

TargetMol aus Boston (Massachusetts) wurde 2015 gegründet und ist ein Experte für Wirkstoffscreening in der Life Science-Community. Das Unternehmen bietet diverse Substanzbibliotheken, darunter FDA-zugelassene Bibliotheken, an und deckt ein breites Spektrum an niedermolekularen Verbindungen wie Inhibitoren und Agonisten sowie rekombinante Proteine und Naturstoffe ab. Die Produkte von TargetMol werden von Forschenden weltweit in Bereichen wie Krebsforschung, Neurobiologie, Inflammation, Immunologie oder Metabolismus eingesetzt.

Mehr Informationen unter: www.targetmol.com

Zu den Katalogen von TargetMol

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HDAC8-IN-2

Artikelnummer: TGM-T61549-100mg

Description: HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor with IC50 values of 0.27 µM and 0.32 µM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. It effectively kills schistosome larvae and significantly reduces egg laying in adult worm pairs [1]. Target: Others

MW:

376.36 D

ab 1.440,00 €

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Antileishmanial agent-5

Artikelnummer: TGM-T61560-100mg

Description: Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L. infantum and T. cruzi, exhibiting EC50 values of 0.68 µM and 0.83 µM, respectively [1]. Target: Others

MW:

376.79 D

ab 1.440,00 €

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VEGFR-2-IN-18

Artikelnummer: TGM-T61561-100mg

Description: VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, exhibiting an IC50 value of 60 nM. This compound effectively induces cell apoptosis and demonstrates significant antitumor properties [1]. Target: Others

MW:

376.8 D

ab 1.440,00 €

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Vanin-1-IN-3

Artikelnummer: TGM-T61568-100mg

Description: Vanin-1-IN-3 (OMP-7) is a vanin-1 inhibitor with an IC50 of 0.038 µM [1]. Target: Others

MW:

377.36 D

ab 1.440,00 €

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Mt KARI-IN-1

Artikelnummer: TGM-T61569-100mg

Description: Mt KARI-IN-1 is a lead compound that demonstrates strong inhibitory activity towards Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 3.06 µM [1]. Target: Others

MW:

377.4 D

ab 1.440,00 €

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MtTMPK-IN-5

Artikelnummer: TGM-T61573-100mg

Description: MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 of 34 µM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, with an MIC of 12.5 µM. Given its potent...

MW:

377.44 D

ab 1.440,00 €

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PD-L1-IN-1

Artikelnummer: TGM-T61574-100mg

Description: PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9...

MW:

377.44 D

ab 815,00 €

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LasR-IN-2

Artikelnummer: TGM-T61581-100mg

Description: LasR-IN-2, a compound that inhibits the activity of LasR, forms hydrogen bonding with the TRY-56 residue. It finds application in the study of bacterial infection, neutropenia, severe burns, and chronic lung disease in cystic fibrosis (CF) [1]. Target: Others

MW:

377.82 D

ab 1.440,00 €

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CDK/HDAC-IN-1

Artikelnummer: TGM-T61583-100mg

Description: CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively. Target: Others

MW:

378.38 D

ab 1.440,00 €

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AMS-17

Artikelnummer: TGM-T61709-100mg

Description: AMS-17 is a potent NLRP3 inhibitor that effectively suppresses microglia activation both in vitro and in vivo. Moreover, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-alpha, IL-1beta, and inducible nitric oxide synthase (iNOS), in N9 cells, making it a promising tool...

MW:

386.35 D

ab 1.440,00 €

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Trk-IN-8

Artikelnummer: TGM-T61712-100mg

Description: Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1]. Target: Others

MW:

386.36 D

ab 1.440,00 €

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COX-2-IN-13

Artikelnummer: TGM-T61714-100mg

Description: COX-2-IN-13 (compound 13e) is a highly potent and selective COX-2 inhibitor with an impressive IC50 value of 0.98 µM. It exhibits strong anti-inflammatory activity and has shown favorable results in in vivo acute toxicity studies [1]. Target: Others

MW:

386.42 D

ab 1.440,00 €

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