Produkte von TargetMol

TargetMol aus Boston (Massachusetts) wurde 2015 gegründet und ist ein Experte für Wirkstoffscreening in der Life Science-Community. Das Unternehmen bietet diverse Substanzbibliotheken, darunter FDA-zugelassene Bibliotheken, an und deckt ein breites Spektrum an niedermolekularen Verbindungen wie Inhibitoren und Agonisten sowie rekombinante Proteine und Naturstoffe ab. Die Produkte von TargetMol werden von Forschenden weltweit in Bereichen wie Krebsforschung, Neurobiologie, Inflammation, Immunologie oder Metabolismus eingesetzt.

Mehr Informationen unter: www.targetmol.com

Zu den Katalogen von TargetMol

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MtTMPK-IN-8

Artikelnummer: TGM-T63491-100mg

Description: MtTMPK-IN-8 is a moderately potent inhibitor of Mycobacterium thymidylate kinase (MtbTMPK) with no significant cytotoxicity, exhibiting submicromolar activity (MICs = 0.78-9.4 µM) against Mycobacterium and capable of being used in the study of tuberculosis. Target: Others

MW:

508.48 D

ab 1.440,00 €

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CYP2C1/CYP2C19-IN-2

Artikelnummer: TGM-T63495-100mg

Description: CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection. Target: Others

MW:

508.59 D

ab 1.440,00 €

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CYP2C9/CYP2C19-IN-1

Artikelnummer: TGM-T63496-100mg

Description: CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection. Target: Others

MW:

508.59 D

ab 1.440,00 €

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Chroman 1 dihydrochloride

Artikelnummer: TGM-T63506-100mg

Description: Chroman 1 dihydrochloride is a selective and potent inhibitor of ROCK, acting more strongly on ROCK2 (IC50: 1 pM) than ROCK1 (IC50: 52 pM) and also inhibiting MRCK activity (IC50: 150 nM). Target: Others

MW:

509.43 D

ab 1.440,00 €

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Top/HDAC-IN-1

Artikelnummer: TGM-T63509-100mg

Description: Top/HDAC-IN-1 is a dual topoisomerase (Top)/HDAC inhibitor that acts on HDAC1 (IC50: 18 nM), HDAC2 (IC50: 230 nM), HDAC3 (IC50: 790 nM), HDAC6 (IC50: 87 nM) and HDAC8 (IC50: 5250 nM). Top/HDAC-IN-1 exhibited potent antitumor effects on HCT116 cells (IC50: 180 nM), blocked the cell cycle of HCT116 cells...

MW:

509.56 D

ab 1.440,00 €

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PPARgamma agonist 1

Artikelnummer: TGM-T63514-100mg

Description: PPARgamma agonist 1 is a potent agonist of PPARgamma that efficiently activates hPPARgamma without causing full agonism, thereby avoiding adverse effects. ppargamma agonist 1 has shown research potential in cardiovascular diseases associated with metabolic disorders. Target: Others

MW:

509.68 D

ab 1.440,00 €

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Bcl-2-IN-7

Artikelnummer: TGM-T63521-100mg

Description: Bcl-2-IN-7 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2), which can downregulate the expression of Bcl-2, increase the expression of p53, Bax, caspase-7 mRNA, and induce cell cycle arrest and apoptosis in MCF-7 cells of breast cancer. Bcl2-IN-7 showed good antitumor activity against MCF-7 cells...

MW:

510.59 D

ab 1.440,00 €

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Antitubercular agent-23

Artikelnummer: TGM-T63525-100mg

Description: Antitubercular agent-23 is an effective anti-Candida and anti-tuberculosis agent against Candida albicans MTCC 3017 (MIC: 1.1 µg/ml) and M. tuberculosis (H37Rv) (MIC: 1 µg/ml). Target: Others

MW:

511.48 D

ab 1.440,00 €

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Topoisomerase I/II inhibitor 4

Artikelnummer: TGM-T63526-100mg

Description: Topoisomerase I/II inhibitor 4 is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) with inhibitory effects on cell proliferation, invasion and migration, and induction of apoptosis, and can be used to study hepatocellular carcinoma. Target: Others

MW:

511.49 D

ab 1.440,00 €

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HSP90-IN-11

Artikelnummer: TGM-T63528-100mg

Description: HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90alpha inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cells, HSP90-IN-11 exhibited significant anti-proliferative activity in the...

MW:

511.54 D

ab 1.440,00 €

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ZIKV-IN-4

Artikelnummer: TGM-T63533-100mg

Description: ZIKV-IN-4 is a low cytotoxic, acid-stable anti-ZIKV agent with an EC50 value of 3.49 µM. ZIKV-IN-4 exhibited potent inhibition of ZIKV NS5 MTase. Target: Others

MW:

511.65 D

ab 1.440,00 €

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FAK-IN-3

Artikelnummer: TGM-T63545-100mg

Description: FAK-IN-3 is a potent inhibitor of adherens spot kinase (FAK). FAK-IN-3 reduces migration and invasion of PA-1 cells and inhibits the expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis with no significant adverse effects. FAK-IN-3 has shown investigational potential in ovarian...

MW:

512.56 D

ab 1.440,00 €

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