Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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AMG-51
Artikelnummer: SYN-1111-M001
Soluble in DMSO. c-Met kinase is the receptor for hepatocyte growth factor (HGFR). Primarily expressed on epithelial and mesenchymal cells its normal function is associated with wound healing, liver regeneration and embryo development. However, dysregulation of c-Met through overexpression, gene amplification,...
| Schlagworte: | AMG51 |
| Anwendung: | MET inhibitor |
| CAS | 890019-63-3 |
| MW: | 629,7 D |
ab 293,00 €
GNE-490
Artikelnummer: SYN-1114-M001
Soluble in DMSO. GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR. It has good pharmacokinetic (PK) parameters and demonstrates knock down of pathway markers in vivo. Originally obtained via modification of compounds like GDC-0941, GNE-490 which have a significantly reduced...
| Schlagworte: | GNE490 |
| Anwendung: | PI3K inhibitor |
| CAS | 1033739-92-2 |
| MW: | 386,5 D |
ab 293,00 €
S-99
Artikelnummer: SYN-1119-M001
Soluble in DMSO or ethanol. S-99 inhibits LPS-induced TNFalpha release assay in vivo.
| Schlagworte: | S99 |
| Anwendung: | Inhibitor of LPS-induced TNF alpha release |
| CAS | 1124381-69-6 |
| MW: | 364,3 D |
ab 293,00 €
GSK-2126458
Artikelnummer: SYN-1126-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK2126458 is an orally available selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) enzymes and MTOR1/2 complexes. GSK2126458 can inhibit PI3K-alpha (p85alpha/p110alpha) with IC(50) of 0.04nM. GSK2126458 has Ki values in the picomolar range...
| Schlagworte: | HYR-582 |
| Anwendung: | PI3K / mTOR inhibitor |
| CAS | 1086062-66-9 |
| MW: | 505,5 D |
ab 223,00 €
JNJ-38158471
Artikelnummer: SYN-1133-M001
Soluble in DMSO. JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (>1µM) against VEGFR-1 and VEGFR-3. Target: VEGFR-2 ,...
| Schlagworte: | JNJ38158471 |
| Anwendung: | VEGFR-2 inhibitor |
| CAS | 951151-97-6 |
| MW: | 364,8 D |
ab 293,00 €
Pelitinib
Artikelnummer: SYN-1141-M001
Soluble in DMSO or ethanol. Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib...
| Schlagworte: | EKB-569 |
| Anwendung: | EGFR inhibitor |
| CAS | 257933-82-7 |
| MW: | 467,9 D |
ab 123,00 €
AMG-458
Artikelnummer: SYN-1144-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.
| Schlagworte: | AMG458 |
| Anwendung: | MET inhibitor |
| CAS | 913376-83-7 |
| MW: | 539,6 D |
ab 193,00 €
MK-2461
Artikelnummer: SYN-1149-M001
Soluble in DMSO or ethanol. MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC(50) values of 0.4 to 2.5nM.
| Schlagworte: | MK2461 |
| Anwendung: | Activated MET inhibitor |
| CAS | 917879-39-1 |
| MW: | 495,6 D |
ab 254,00 €
TAK-285
Artikelnummer: SYN-1153-M001
Soluble in DMSO or ethanol. TAK-285 is a novel investigational dual HER2/EGFR inhibitor with IC(50) values of 17 and 23nM, respectively. Target: EGFR - HER2 , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | TAK285 |
| Anwendung: | EGFR / HER2 inhibitor |
| CAS | 871026-44-7 |
| MW: | 548 D |
ab 254,00 €
AZD-26
Artikelnummer: SYN-1160-M001
Soluble in DMSO or ethanol. AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM...
| Schlagworte: | AZD26 |
| Anwendung: | AKT inhibitor |
| CAS | 1357158-81-6 |
| MW: | 343,4 D |
ab 300,00 €
SAR-131675
Artikelnummer: SYN-1165-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45nM, respectively. SAR131675 dose dependently inhibited the proliferation of primary...
| Schlagworte: | SAR131675 |
| Anwendung: | VEGFR-3 inhibitor |
| CAS | 1092539-44-0 |
| MW: | 358,4 D |
ab 293,00 €
IPI-145
Artikelnummer: SYN-1175-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies. Target: PI3K , Kinase Group: Atypical (PIKK) ,...
| Schlagworte: | IPI 145 |
| Anwendung: | PI3K gamma / delta inhibitor |
| CAS | 1201438-56-3 |
| MW: | 416,9 D |
ab 162,00 €