Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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AV-412
Artikelnummer: SYN-1012-M001
Soluble in DMSO or ethanol. AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the...
| Schlagworte: | MP-412, AV412 |
| Anwendung: | EGFR / ErbB2 inhibitor |
| CAS | 451492-95-8 |
| MW: | 507 D |
ab 293,00 €
AZD-7762 hydrochloride
Artikelnummer: SYN-1017-M001
Soluble in DMSO or ethanol. Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies....
| Schlagworte: | AZD7762 |
| Anwendung: | CHK1/2 inhibitor |
| CAS | 1246094-78-9 |
| MW: | 398,9 D |
ab 123,00 €
CC-401 hydrochloride
Artikelnummer: SYN-1028-M001
Soluble in DMSO. CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least...
| Schlagworte: | CC401 |
| Anwendung: | JNK inhibitor |
| CAS | 1438391-30-0 |
| MW: | 424,9 D |
ab 177,00 €
Dianilinopyrimidine_01
Artikelnummer: SYN-1037-M001
Soluble in DMSO. Dianilinopyrimidine_01 is a pan tyrosine kinase inhibitor Target: Pan-Tyrosine Kinase , Substrate: Tyrosine
| Anwendung: | Pan Tyrosine Kinase inhibitor |
| CAS | 916603-07-1 |
| MW: | 309,3 D |
ab 231,00 €
GDC-0941
Artikelnummer: SYN-1041-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold). Target: PI3K , Kinase Group:...
| Schlagworte: | GDC0941 |
| Anwendung: | PI3K inhibitor |
| CAS | 957054-30-7 |
| MW: | 513,6 D |
ab 123,00 €
Amuvatinib
Artikelnummer: SYN-1056-M001
Soluble in DMSO or ethanol. Amuvatinib is a potent, novel and orally active multi-targeted tyrosine kinase inhibitor, which inhibits a number of validated tumor targets including c-kit, PDGFRalpha and flt3, with IC(50) values of 10nM, 40nM and 81nM respectively. Target: PDGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | MP-470 |
| Anwendung: | c-KIT / PDGFR inhibitor |
| CAS | 850879-09-3 |
| MW: | 447,5 D |
ab 154,00 €
PD-173955-Analog1
Artikelnummer: SYN-1062-M001
Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water. PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively. Substrate: Tyrosine
| Schlagworte: | PD173955-Analog1, PD-173,955-Analog1 |
| Anwendung: | c-Src / CSK inhibitor |
| CAS | 185039-99-0 |
| MW: | 441,3 D |
ab 231,00 €
SD-06
Artikelnummer: SYN-1078-M001
Soluble in DMSO. SD-06 is a p38 MAP kinase inhibitor. It inhibits p38alpha with an IC(50) value of 170nM and inhibits LPS-stimulated TNF-release in rats. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
| Schlagworte: | SD06 |
| Anwendung: | p38 inhibitor |
| CAS | 271576-80-8 |
| MW: | 397,9 D |
ab 293,00 €
BMS-387032
Artikelnummer: SYN-1080-M001
Soluble in DMSO or ethanol. BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It...
| Schlagworte: | BMS387032, SNS-032 |
| Anwendung: | CDK2 / CDK9 inhibitor |
| CAS | 345627-90-9 |
| MW: | 417,0 D |
ab 100,00 €
SNS-314
Artikelnummer: SYN-1081-M001
Soluble in DMSO or ethanol. Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes,...
| Schlagworte: | SNS314 |
| Anwendung: | Aurora inhibitor |
| CAS | 1057249-41-8 |
| MW: | 430,9 D |
ab 123,00 €
Danusertib
Artikelnummer: SYN-1095-M001
Soluble in DMSO or ethanol. Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid...
| Schlagworte: | PHA-739358 |
| Anwendung: | Aurora inhibitor |
| CAS | 827318-97-8 |
| MW: | 474,6 D |
ab 162,00 €
TG100115
Artikelnummer: SYN-1105-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. TG100115 inhibits PI3K gamma and delta, with IC(50) values of 83 and 235nM, respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | TG-100115 |
| Anwendung: | PI3K gamma / delta inhibitor |
| CAS | 677297-51-7 |
| MW: | 346,3 D |
ab 154,00 €