Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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MLN-0128
Artikelnummer: SYN-1157-M001
Soluble in DMSO or ethanol. MLN0128 is a potent and selective mTOR inhibitor with an IC(50) of 1nM, >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).
| Schlagworte: | MLN-0128, INK-128 |
| Anwendung: | mTOR inhibitor |
| CAS | 1224844-38-5 |
| MW: | 309,3 D |
ab 146,00 €
GCI-1746
Artikelnummer: SYN-1164-M001
Soluble in DMSO or ethanol. CGI1746 was identified as a selective and potent ATP-competitive BTK inhibitor with an IC(50) of 1.9nM. It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases. Target: BTK , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | GCI-1746, G-182 |
| Anwendung: | BTK inhibitor |
| CAS | 910232-84-7 |
| MW: | 579,7 D |
ab 254,00 €
SCH-900776
Artikelnummer: SYN-1173-M001
Soluble in DMSO or ethanol. SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2. Target: Chk1 , Kinase Group: CAMK , Substrate: Serine-Threonine
| Schlagworte: | MK-8776 |
| Anwendung: | Chk1 inhibitor |
| CAS | 891494-63-6 |
| MW: | 376,3 D |
ab 162,00 €
CX-6258
Artikelnummer: SYN-1182-M001
Soluble in DMSO. CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively. Target: PKC - PKC alpha, , Kinase Group: STE , Substrate: Serine-Threonine
| Schlagworte: | CX6258 |
| Anwendung: | Pim-1 / Pim-2 / Pim-3 inhibitor |
| CAS | 1202916-90-2 |
| MW: | 461,9 D |
ab 293,00 €
AZD-8330
Artikelnummer: SYN-1195-M001
Soluble in DMSO or ethanol. AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with an IC(50) of 7nM. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine
| Schlagworte: | AZD8330 |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 869357-68-6 |
| MW: | 461,2 D |
ab 154,00 €
TAK-632
Artikelnummer: SYN-1203-M001
Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water.TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC(50) of 2.4nM. Target: Raf , Kinase Group: TKL , Substrate: Serine-Threonine
| Schlagworte: | TAK632 |
| Anwendung: | Raf inhibitor |
| CAS | 1228591-30-7 |
| MW: | 554,5 D |
ab 108,00 €
CFI-400437
Artikelnummer: SYN-1207-M001
CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10µM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft...
| Schlagworte: | (E)-5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one... |
| Anwendung: | Potent PLK4 inhibitor |
| MW: | 565.5 D |
ab 293,00 €
TASP0415914
Artikelnummer: SYN-1208-M001
Soluble in DMSO. PI3Kgamma is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-inflammatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine...
| Schlagworte: | TASP-0415914 |
| Anwendung: | PI3K gamma inhibitor |
| CAS | 1292300-75-4 |
| MW: | 323,4 D |
ab 231,00 €
S49076 HCl
Artikelnummer: SYN-1217-M001
Solid. Soluble in DMSO. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block...
| Schlagworte: | S-49076 . HCl, (Z)-3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione... |
| Anwendung: | MET AXL/MER & FGFR1/2/3 inhibitor |
| CAS | 1265965-19-2 |
| MW: | 475,0 D |
ab 123,00 €
MBP146-78
Artikelnummer: SYN-1227-M001
MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG....
| Schlagworte: | 4-[2-(4-Fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl] pyridine |
| Anwendung: | Eimeria spp. cGMP-dependent protein kinase (PKG) inhibitor |
| CAS | 188343-77-3 |
| MW: | 335.4 D |
ab 108,00 €
Linifanib
Artikelnummer: SYN-1002-M001
Soluble in DMSO or ethanol. Linifanib (A 741439, A-741439, A741439, ABT-869, ABT869, RG3635) is an orally active multi-targeted receptor tyrosine kinase inhibitor for the treatment of various cancers. The compound is designed to inhibit vascular endothelial growth factor and platelet-derived growth factor receptors...
| Schlagworte: | ABT-869, AL39324, RG-3635 |
| Anwendung: | PDGFR / VEFGR inhibitor |
| CAS | 796967-16-3 |
| MW: | 375,4 D |
ab 123,00 €
AMG-47a
Artikelnummer: SYN-1007-M001
Soluble in DMSO. The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to...
| Schlagworte: | AMG47a |
| Anwendung: | Lck inhibitor |
| CAS | 882663-88-9 |
| MW: | 535,6 D |
ab 300,00 €