Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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VX-702
Artikelnummer: SYN-1093-M001
Soluble in DMSO or ethanol. The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely...
| Schlagworte: | VX702 |
| Anwendung: | P38 inhibitor |
| CAS | 745833-23-2 |
| MW: | 404,3 D |
ab 77,00 €
YM201636 hydrochloride
Artikelnummer: SYN-1094-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC(50) of 33nM). It disrupts retroviral budding from cells, apparently by interfering with the endosomal sorting complex required for transport (ESCRT) machinery. In adipocytes, YM-201636 also...
| Schlagworte: | YM-201636 |
| Anwendung: | PIKfyve inhibitor |
| CAS | 371942-69-7 |
| MW: | 503,9 D |
ab 154,00 €
PIK-294
Artikelnummer: SYN-1098-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PIK-294 is a PI3 Kinase inhibitor that is 20- to 60-fold more potent than the parent compound, PIK-293. It is one of the most potent p110delta-selective inhibitors that has been reported, with an IC(50) of 10nM. Target: PI3K , Kinase Group: Lipid Kinase ,...
| Schlagworte: | PIK294 |
| Anwendung: | PI3K p110 delta inhibitor |
| CAS | 900185-02-6 |
| MW: | 489,5 D |
ab 162,00 €
ZSTK474
Artikelnummer: SYN-1099-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ZSTK474 inhibits all four PI3K isoforms in an ATP-competitive manner. IC(50) is approximately 37nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | ZSTK-474 |
| Anwendung: | PI3K inhibitor |
| CAS | 475110-96-4 |
| MW: | 417,4 D |
ab 77,00 €
TG101209
Artikelnummer: SYN-1103-M001
Soluble in DMSO or ethanol. TG101209 is a potent, small molecule JAK2-selective kinase inhibitor with IC(50) values of 6, 25, 17 and 169nM for JAK2, FLT3, RET and JAK3. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | TG-101209 |
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-14-4 |
| MW: | 509,7 D |
ab 177,00 €
TG101348
Artikelnummer: SYN-1104-M001
Soluble in DMSO or ethanol. TG101348 inhibits JAK2(V617F) with an IC(50) of 3nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2(V617F) cells. Target: JAK , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | SAR-302503, TG-101348 |
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-26-8 |
| MW: | 524,7 D |
ab 92,00 €
TG-46
Artikelnummer: SYN-1106-M001
Soluble in DMSO or ethanol. TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3 with IC(50) values of 6nM, 25nM, 17nM, 169nM respectively. Target: JAK , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | TG46 |
| Anwendung: | JAK2 / FLT3 / RET / JAK3 inhibitor |
| CAS | 936091-15-5 |
| MW: | 510,7 D |
ab 293,00 €
AMG-25
Artikelnummer: SYN-1125-M001
Soluble in DMSO. AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.
| Schlagworte: | AMG25 |
| Anwendung: | c-Kit inhibitor |
| CAS | 1003311-62-3 |
| MW: | 395,4 D |
ab 293,00 €
R-428
Artikelnummer: SYN-1131-M001
Soluble in DMSO or ethanol. R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and...
| Schlagworte: | R-428 |
| Anwendung: | AXL inhibitor |
| CAS | 1037624-75-1 |
| MW: | 506,6 D |
ab 385,00 €
XL-765
Artikelnummer: SYN-1137-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. XL765 is active against class I PI3K (IC(50) = 39, 113, 9 and 43nM for p110alpha, beta, gamma and delta, respectively). XL765 also inhibits DNA-PK (IC(50) = 150nM) and mTOR (IC(50) = 157nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | SAR-245409 |
| Anwendung: | PI3K / DNA-PK / mTOR inhibitor |
| CAS | 1349796-36-6 |
| MW: | 599,7 D |
ab 193,00 €
AMG-1
Artikelnummer: SYN-1143-M001
Soluble in DMSO. AMG-1 is a potent inhibitor of human c-Met and RON with IC(50) values of 4 and 9nM respectively. Target: c-Met - RON , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | AMG1 |
| Anwendung: | c-Met / RON inhibitor |
| CAS | 913376-84-8 |
| MW: | 556,6 D |
ab 254,00 €
GNE-477
Artikelnummer: SYN-1148-M001
Soluble in DMSO. GNE 477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC(50) value of 4nM and 21nM respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | GNE477 |
| Anwendung: | PI3K / mTOR inhibitor |
| CAS | 1032754-81-6 |
| MW: | 504,6 D |
ab 300,00 €