Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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Quisinostat
Artikelnummer: SYN-3029-M001
Quisinostat (JNJ-26481585) is a novel second-generation panHDAC inhibitor of HDAC1, 2, 4, 10 and 11. Its highest potency is against HDAC1 with an IC50 of 0.11nM. It has only modest potency against HDACs 2, 4, 10, and 11 (IC50 ranging from 0.33nM to 0.64nM). It has low activity against HDACs 3, 5, 8, and 9 and its...
| Schlagworte: | JNJ-26481585 |
| Anwendung: | pan-HDAC inhibitor (HDAC1, 2, 4, 10, 11) |
| CAS | 875320-29-9 |
| MW: | 394.5 D |
ab 139,00 €
BX-795
Artikelnummer: SYN-1026-M001
Soluble in DMSO or ethanol. BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC(50) 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-epsilon. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of...
| Schlagworte: | BX795 |
| Anwendung: | PDPK1 inhibitor |
| CAS | 702675-74-9 |
| MW: | 591,5 D |
ab 100,00 €
PI103
Artikelnummer: SYN-1065-M050
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110alpha-delta with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively. Target: PI3K -...
| Schlagworte: | PI-103 |
| Anwendung: | PI3K / DNA-PK / mTOR inhibitor |
| CAS | 371935-74-9 |
| MW: | 348,4 D |
ab 146,00 €
Bentamapimod
Artikelnummer: SYN-1147-M001
Soluble in DMSO. Bentamapimod (AS602801) is a novel and orally active c-Jun-N-Terminal Kinase Inhibitor highly specific for JNK kinases. The inhibitor Bentamapimod (AS602801) is a potent anti-inflammatory agent which has been shown to reduce the disease burden in several pre-clinical models for endometriosis, and...
| Schlagworte: | AS-602801 |
| Anwendung: | JNK inhibitor |
| CAS | 848344-36-5 |
| MW: | 457,6 D |
ab 293,00 €
AZD-2014
Artikelnummer: SYN-1167-M005
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AZD2014 is a dual mTORC1/mTORC2 inhibitor for the treatment of advanced solid malignancies. Target: mTOR , Kinase Group: Atypical (PIKK) , Substrate: Serine-Threonine
| Schlagworte: | AZD2014 |
| Anwendung: | mTOR inhibitor |
| CAS | 1009298-59-2 |
| MW: | 462,5 D |
ab 154,00 €
VTX-27
Artikelnummer: SYN-1206-M001
Soluble in DMSO. VTX-27 is a potent and selective inhibitor of the PKCtheta enzyme, with over 1000-fold against classical isoforms and over 10000-fold against atypical isoforms. Target: PKC theta
| Schlagworte: | VTX27 |
| Anwendung: | PKC theta inhibitor |
| CAS | 1321924-70-2 |
| MW: | 418,9 D |
ab 339,00 €
CCT244747
Artikelnummer: SYN-1216-M001
Solid. Soluble in DMSO. CCT244747 is a novel, potent, highly selective, orally active, ATP competitive CHK1 inhibitor. CCT244747 can inhibit cellular CHK1 activity with an IC50 of 29-170nM. In multiple tumour cell models, this has the effect of significantly enhancing the cytotoxicity of several anticancer drugs...
| Schlagworte: | (R)-3-((1-(Dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonit... |
| Anwendung: | Potent, highly selective CHK1 inhibitor |
| CAS | 1404095-34-6 |
| MW: | 408,5 D |
ab 139,00 €
BX-912
Artikelnummer: SYN-1027-M001
Soluble in DMSO or ethanol. BX912 is a PDK1 (3-Phosphoinositide-dependent Kinase-1) inhibitor, with an IC(50) of 26nM. Target: PDK1 , Kinase Group: AGC , Substrate: Serine-Threonine
| Schlagworte: | BX912 |
| Anwendung: | PDPK1 inhibitor |
| CAS | 702674-56-4 |
| MW: | 471,4 D |
ab 100,00 €
IC87114
Artikelnummer: SYN-1045-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kdelta. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not adhesion...
| Schlagworte: | IC-87114 |
| Anwendung: | PI3K delta inhibitor |
| CAS | 371242-69-2 |
| MW: | 397,4 D |
ab 92,00 €
Lapatinib
Artikelnummer: SYN-1052-M001
Soluble in DMSO or ethanol. Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor, with IC(50) values of 10.8 and 9.2nM respectively. It is an orally active drug for treatment of breast cancer and other solid tumors. Target: EGFR , Kinase Group:...
| Schlagworte: | GW-572016 |
| Anwendung: | EGFR / ErbB2 inhibitor |
| CAS | 231277-92-2 |
| MW: | 581,1 D |
ab 77,00 €
Motesanib
Artikelnummer: SYN-1055-M001
Soluble in DMSO or ethanol. Motesanib (AMG 706) is a multi-targeted anti-cancer agent with an inhibitory action on human vascular endothelial growth factor receptors 1, 2 and 3 (VEGFR1-3) with IC(50) values of 2nM, 3nM and 6nM. It also inhibits platelet-derived growth factor receptor (PDGFR) and cellular stem-cell...
| Schlagworte: | AMG706 |
| Anwendung: | VEGFR / PDGFR inhibitor |
| CAS | 453562-69-1 |
| MW: | 373,5 D |
ab 100,00 €
SB-590885
Artikelnummer: SYN-1077-M001
Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
| Schlagworte: | SB-590885 |
| Anwendung: | BRAF inhibitor |
| CAS | 405554-55-4 |
| MW: | 453,5 D |
ab 123,00 €