Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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LEE011
Artikelnummer: SYN-1213-M001
Solid. Soluble in DMSO. Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation...
| Schlagworte: | LEE-011, Ribociclib |
| Anwendung: | CDK4/CDK6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434,5 D |
ab 77,00 €
Selonsertib Hydrochloride
Artikelnummer: SYN-1229-M001
Solid. Soluble in DMSO or ethanol. LY2784544 is a potent JAK2 inhibitor with IC(50) of 3nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.
| Schlagworte: | LY-2784544 |
| Anwendung: | JAK2 inhibitor |
| CAS | 1448428-05-4 |
| MW: | 469,9 D |
ab 139,00 €
ER-172594-06
Artikelnummer: SYN-3002-M001
Soluble in DMSO. E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031µM, respectively.
| Schlagworte: | Atopaxar hydrobromide, ER-172594-06, E5555 |
| Anwendung: | Platelet aggregation inhibitor |
| CAS | 474550-69-1 |
| MW: | 689,4 D |
ab 300,00 €
AT9283
Artikelnummer: SYN-1011-M001
Soluble in DMSO or ethanol. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also...
| Schlagworte: | AT-9283 |
| Anwendung: | Aurora inhibitor |
| CAS | 896466-04-9 |
| MW: | 381,4 D |
ab 123,00 €
CP-724714
Artikelnummer: SYN-1033-M010
Soluble in DMSO or ethanol. CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has >640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met. Target: HER2 , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | CP724714 |
| Anwendung: | HER2 inhibitor |
| CAS | 383432-38-0 |
| MW: | 469,5 D |
ab 123,00 €
PF-04217903
Artikelnummer: SYN-1060-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PF04217903 is a novel orally bio-available, small molecule tyrosine kinase inhibitor with potential anti-neoplastic activity. It is an extremely selective MET inhibitor, with an IC(50) of 4.8nM. Target: MET , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | PF04217903 |
| Anwendung: | MET inhibitor |
| CAS | 956905-27-4 |
| MW: | 372,4 D |
ab 92,00 €
PD-173955
Artikelnummer: SYN-1061-M001
PD173955 is an ATP-competitive, dual Src/Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of...
| Schlagworte: | PD173955, PD-173,955 |
| Anwendung: | BCR-Abl inhibitor |
| CAS | 260415-63-2 |
| MW: | 443,4 D |
ab 254,00 €
TAK-715
Artikelnummer: SYN-1087-M005
Soluble in DMSO or ethanol. TAK-715 is a potent specific inhibitor of the p38alpha MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38alpha over p38beta. It shows no inhibition of p38gamma/delta. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
| Schlagworte: | TAK715 |
| Anwendung: | p38 alpha inhibitor |
| CAS | 303162-79-0 |
| MW: | 399,5 D |
ab 108,00 €
RO-495
Artikelnummer: SYN-1128-M010
Soluble in DMSO. RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology. Target: TYK2 , Kinase...
| Schlagworte: | RO-495 |
| Anwendung: | TYK2 inhibitor |
| CAS | 1258296-60-4 |
| MW: | 389,2 D |
ab 300,00 €
CEP-33779
Artikelnummer: SYN-1156-M001
Soluble in DMSO or ethanol. CEP-33779 is a highly selective, orally active inhibitor for JAK2 with an IC(50) of 1.8nM in enzyme and 61nM in cell activity. It inhibits JAK3 with an IC(50) of 150nM. Target: JAK , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | CEP33779 |
| Anwendung: | JAK2 inhibitor |
| CAS | 1346168-57-7 |
| MW: | 462,6 D |
ab 223,00 €
BLZ-945
Artikelnummer: SYN-1197-M001
Soluble in DMSO. BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC(50) of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRbeta ) as well as more than...
| Schlagworte: | BLZ945 |
| Anwendung: | CSF1R / c-FMS inhibitor |
| CAS | 953769-46-5 |
| MW: | 398,5 D |
ab 246,00 €
AZD1208
Artikelnummer: SYN-1214-M005
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at < 5nM or < 150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3...
| Schlagworte: | AZD-1208 |
| Anwendung: | Pim kinase inhibitor |
| CAS | 1204144-28-4 |
| MW: | 379,5 D |
ab 92,00 €