Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
Mehr Informationen unter: www.adipogen.com/synkinase
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SGX-523
Artikelnummer: SYN-1155-M001
Soluble in DMSO. Slightly soluble ( 36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase. Target: c-Met , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | SGX523 |
| Anwendung: | c-Met inhibitor |
| CAS | 1072116-01-8 |
| MW: | 359,4 D |
ab 154,00 €
Takeda-6d
Artikelnummer: SYN-1168-M001
Soluble in DMSO. Takeda-6d has potent inhibitory activity in both B-RAF with an IC(50) of 7.0nM and VEGFR2 with an IC(50) of 2.2nM. Target: B-RAF - VEGFR2 , Kinase Group: TKL , Substrate: Serine-Threonine
| Schlagworte: | Takeda 6d |
| Anwendung: | B-RAF / VEGFR2 inhibitor |
| CAS | 1125632-93-0 |
| MW: | 548 D |
ab 300,00 €
BGT-226 maleate
Artikelnummer: SYN-1178-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. BGT226 is a novel, orally bioavailable small-molecule inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin with an IC(50) of 1nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | NVP-BEZ226, BEZ-226 |
| Anwendung: | PI3K / mTOR inhibitor |
| CAS | 1245537-68-1 |
| MW: | 650,6 D |
ab 139,00 €
GNF-5837
Artikelnummer: SYN-1183-M001
Soluble in DMSO. Inhibitor of pan-Trk activity (IC(50) = 8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC(50) = 11,...
| Schlagworte: | GNF5837 |
| Anwendung: | TrkA / TrkB inhibitor |
| CAS | 1033769-28-6 |
| MW: | 535,5 D |
ab 123,00 €
CH-4987655
Artikelnummer: SYN-1188-M001
Soluble in DMSO. CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor with an in vitro IC(50) of 5.2nM. Target: MEK , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | RO4987655 |
| Anwendung: | MEK inhibitor |
| CAS | 874101-00-5 |
| MW: | 565,3 D |
ab 293,00 €
SGI-1776
Artikelnummer: SYN-1193-M001
Soluble in DMSO or ethanol. SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. Target: Pim1 - Pim2 - Pim3 , Kinase Group: CAMK , Substrate: Serine-Threonine
| Schlagworte: | SGI1776 |
| Anwendung: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405,4 D |
ab 123,00 €
PF-04979064
Artikelnummer: SYN-1194-M001
Soluble in DMSO. PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM. Target: PI3K - mTOR , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | PF04979064 |
| Anwendung: | PI3K / mTOR inhibitor |
| CAS | 1220699-06-8 |
| MW: | 446,5 D |
ab 300,00 €
GDC-046
Artikelnummer: SYN-1198-M001
Soluble in DMSO. GDC046 is a potent lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile Target: TYK2 , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | GDC046 |
| Anwendung: | TYK2 inhibitor |
| CAS | 1258292-64-6 |
| MW: | 350,2 D |
ab 139,00 €
LDK378
Artikelnummer: SYN-1199-M001
Soluble in DMSO (heat) or ethanol. LDK378 is potent inhibitor against ALK with IC(50) of 0.2nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Target: ALK , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | LDK-378 |
| Anwendung: | ALK inhibitor |
| CAS | 1032900-25-6 |
| MW: | 558,1 D |
ab 92,00 €
GDC-0032
Artikelnummer: SYN-1202-M001
Slightly soluble ( 10 fold selective over PI3Kbeta Target: PI3K , Kinase Group: Lipid Kinases , Substrate: Lipid
| Schlagworte: | GDC0032 |
| Anwendung: | PI3K alpha / delta / gamma inhibitor |
| CAS | 1282512-48-4 |
| MW: | 460,5 D |
ab 123,00 €
URMC-099
Artikelnummer: SYN-1211-M001
Solid. Soluble in DMSO or water. Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinson's disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable...
| Schlagworte: | 3-(1H-Indol-5-yl)-5-(4-(4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3- b]pyridine |
| Anwendung: | MLK-3 inhibitor |
| CAS | 1229582-33-5 |
| MW: | 421,5 D |
ab 154,00 €
BGG463
Artikelnummer: SYN-1226-M001
BGG463 (NVP-BGG463) was generated by a rational 'hybrid design' approach. Like Imatinib, BGG463 disrupts the assembly of the hydrophobic spine, a characteristic feature of the active state of several kinases, thereby locking the kinase in an inactive 'DFG-out' conformation. BGG463 can inhibit c-ABL-T334I, BCR-ABL...
| Schlagworte: | BGG-463 |
| Anwendung: | Kinase active state disruptor |
| CAS | 890129-26-7 |
| MW: | 578.6 D |
ab 293,00 €