Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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CYC116
Artikelnummer: SYN-1034-M001
Soluble in DMSO or ethanol. CYC116 is an orally active small molecule multi-kinase inhibitor with anti-neoplastic activity. CYC116 inhibits Aurora kinases A/B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis....
| Schlagworte: | CYC-116 |
| Anwendung: | Aurora A / B inhibitor |
| CAS | 693228-63-6 |
| MW: | 368,5 D |
ab 92,00 €
Ki-20227
Artikelnummer: SYN-1049-M001
Soluble in DMSO or ethanol. Ki20227 is a c-fms tyrosine kinase inhibitor. It has IC(50) values of 2, 12, 451 and 217nM for c-Fms, VEGFR-2, c-Kit and PDGFRbeta respectively. Target: c-fms , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | Ki-20227 |
| Anwendung: | c-fms inhibitor |
| CAS | 623142-96-1 |
| MW: | 480,5 D |
ab 154,00 €
Masatinib
Artikelnummer: SYN-1053-M001
Soluble in DMSO or ethanol.Masitinib is a potent, orally available protein tyrosine kinase inhibitor targeting c-Kit, PDGFR and FGFR3. It demonstrates activity for Kit and PDGFR alpha/beta with IC(50) values of 200nM, 540nM and 800nM respectively. It shows weak inhibition of ABL and c-Fms. Target: c-Kit, PDGFR and...
| Schlagworte: | AB1010, Masivet |
| Anwendung: | c-Kit inhibitor |
| CAS | 790299-79-5 |
| MW: | 498,7 D |
ab 69,00 €
GSK429286A
Artikelnummer: SYN-1071-M001
Soluble in DMSO. GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats. Target: ROCK , Kinase Group: AGC , Substrate: Serine-Threonine
| Schlagworte: | GSK-429286A, RHO-15 |
| Anwendung: | ROCK inhibitor |
| CAS | 864082-47-3 |
| MW: | 432,4 D |
ab 139,00 €
SB-242235
Artikelnummer: SYN-1076-M001
Soluble in DMSO. The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. SB-242235 is a potent and moderately selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or...
| Schlagworte: | SB-242235 |
| Anwendung: | p38 inhibitor |
| CAS | 193746-75-7 |
| MW: | 353,4 D |
ab 293,00 €
TG-89
Artikelnummer: SYN-1107-M001
Soluble in DMSO or ethanol. TG-89 is a JAK inhibitor. It has IC(50) values of 6, 25, 17 and 169nM against JAK2, FLT3, RET and JAK3 respectively. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | TG89 |
| Anwendung: | JAK2 / FLT3 / RET / JAK3 inhibitor |
| CAS | 936091-56-4 |
| MW: | 510,7 D |
ab 293,00 €
GSK-25
Artikelnummer: SYN-1124-M001
Soluble in DMSO. GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC(50) of 398nM, p70S6K IC(50) of 1000nM), and a dramatically improved P450 profile (>2.2µM at all isozymes tested). Target: RSK1 - p70S6K , Kinase Group: AGC , Substrate: Serine-Threonine
| Schlagworte: | GSK-25 |
| Anwendung: | RSK1 / p70S6K inhibitor |
| CAS | 874119-56-9 |
| MW: | 513,3 D |
ab 293,00 €
Foretinib
Artikelnummer: SYN-1129-M001
Soluble in DMSO. Foretinib is a novel MET and VEGFR2 kinase inhibitor with IC(50) values of 0.4 and 0.8nM for MET and VEGFR2 respectively. Target: VEGFR2 - MET , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | GSK-1363089, EXEL-2880 |
| Anwendung: | VEGFR2 / MET inhibitor |
| CAS | 849217-64-7 |
| MW: | 632,7 D |
ab 162,00 €
NVP-BSK805
Artikelnummer: SYN-1136-M001
Soluble in DMSO or ethanol. NVP-BSK805 is a potent and selective quinoxaline JAK2 inhibitor with IC(50) values of 0.48, 0.56 and 0.58nM for JAK2 JH1, FL JAK (V617F) and FL JAK2 wt, respectively. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | NVPBSK805 |
| Anwendung: | JAK2 inhibitor |
| CAS | 1092499-93-8 |
| MW: | 563,5 D |
ab 254,00 €
BMS-599626
Artikelnummer: SYN-1142-M001
Soluble in DMSO or ethanol. BMS-599626 is an orally bioavailable, highly selective and potent pan-HER kinase inhibitor. It inhibits HER1 and HER2 with IC(50) values of 20 and 30nM, respectively. Target: EGFR - HER2 , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | AC-480, BMS599626 |
| Anwendung: | EGFR / HER2 inhibitor |
| CAS | 714971-09-2 |
| MW: | 530,6 D |
ab 162,00 €
CH-5132799
Artikelnummer: SYN-1146-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. CH5132799 selectively inhibits class I PI3Kalpha with an IC(50) value of 14nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | CH-5132799 |
| Anwendung: | PI3K alpha inhibitor |
| CAS | 1007207-67-1 |
| MW: | 377,4 D |
ab 193,00 €
RG-7422
Artikelnummer: SYN-1150-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC(50) values of 5, 27, 7, and 14nM for PI3Kalpha-delta respectively. It inhibits mTOR with a Ki of 17nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | GDC-0980 |
| Anwendung: | PI3K / mTOR inhibitor |
| CAS | 1032754-93-0 |
| MW: | 498,6 D |
ab 154,00 €