Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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AS-703026
Artikelnummer: SYN-1190-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AS703026 is a novel, selective, non-competitive, orally bioavailable MEK1/2 inhibitor with experimental IC(50) values of 5-11nM. In use on multiple myeloma cells (MM), AS703026 inhibited growth and survival of MM cells and cytokine-induced osteoclast...
| Schlagworte: | AS703026 |
| Anwendung: | JAK2 inhibitor |
| CAS | 1236699-92-5 |
| MW: | 431,2 D |
ab 92,00 €
XL-019
Artikelnummer: SYN-1191-M001
Soluble in DMSO. XL019 is a potent JAK2 inhibitor (IC(50) of 2nM) with excellent selectivity versus the other members of the JAK kinase family (JAK1, IC(50) of 130nM, JAK3, IC(50) of 250nM, TYK2, IC(50) of 340nM).
| Schlagworte: | XL-019 |
| Anwendung: | JAK2 inhibitor |
| CAS | 945750-13-0 |
| MW: | 444,5 D |
ab 293,00 €
KW-2449
Artikelnummer: SYN-1205-M001
Soluble in DMSO or ethanol. KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A, little effect on PDGFRbeta, IGF-1R, EGFR.
| Schlagworte: | KW2449 |
| Anwendung: | FLT3 inhibitor |
| CAS | 841259-17-4 |
| MW: | 368,9 D |
ab 77,00 €
BBT594
Artikelnummer: SYN-1225-M001
BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase...
| Schlagworte: | BBT-594 |
| Anwendung: | Potent, selective RET / JAK2 inhibitor |
| CAS | 882405-89-2 |
| MW: | 569.6 D |
ab 293,00 €
Alpelisib
Artikelnummer: SYN-1230-M001
Solid. Soluble in DMSO or DMF. Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect on other PI3K isoforms. Exhibits favorable pharmacokinetics and excellent oral bioavailability in animal models. In xenografts using nude mice, it showed dose-dependent effects of tumour inhibition. In a phase Ib study,...
| Schlagworte: | (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide, BYL719,... |
| Anwendung: | Selective PI3K alpha inhibitor |
| CAS | 1217486-61-7 |
| MW: | 441,5 D |
ab 123,00 €
Selonsertib
Artikelnummer: SYN-1231-M001
Solid. Soluble in DMSO. Insoluble in water. Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an...
| Schlagworte: | GS-4997 (free base),... |
| Anwendung: | ASK1 inhibitor |
| CAS | 1448428-04-3 |
| MW: | 445,5 D |
ab 139,00 €
I-BET762
Artikelnummer: SYN-3033-M001
I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762...
| Schlagworte: | GSK-525762A |
| Anwendung: | BET (bromodomain and extra terminal domain) protein BRD2 / BRD3 / BRD4 inhibitor |
| CAS | 1260907-17-2 |
| MW: | 423.9 D |
ab 123,00 €
MPI_5a
Artikelnummer: SYN-3040-M001
Solid. Soluble in DMSO. MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50...
| Schlagworte: | MPI5a, N-Hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1259296-46-2 |
| MW: | 299,3 D |
ab 123,00 €
EPZ015666
Artikelnummer: SYN-3044-M001
Off-white solid. Soluble in 100% ethanol (1 mg/ml) or DMSO (10 mg/ml), insoluble in water. Dynamin-1, -2 (DNM1, DNM2) and Dynamin-related protein 1 (DRP1) inhibitor, Endocytosis inhibitor, Viral infection inhibitor, Destabilizes actin filaments, Inhibits entry of Trypanosoma into macrophages, Inhibitor of mitophagy,...
| Schlagworte: | 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzyl-idene)-hydrazide . 0.5H2O |
| CAS | 1616391-65-1 |
ab 123,00 €
AZ9482
Artikelnummer: SYN-3046-M001
AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with...
| Schlagworte: | 2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile |
| Anwendung: | Potent, selective PARP inhibitor |
| CAS | 1825345-33-2 |
| MW: | 450.5 D |
ab 139,00 €
Akt-I-1
Artikelnummer: SYN-1005-M001
Soluble in DMSO. The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, AKT-I-1 blocked the...
| Schlagworte: | AktI1 |
| Anwendung: | Akt1 inhibitor |
| CAS | 473382-39-7 |
| MW: | 378,5 D |
ab 300,00 €
BI-D1870
Artikelnummer: SYN-1020-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC(50)s are 31nM, 24nM, 18nM, 15nM, respectively. It shows a 10- to 100-fold selectivity for RSK over MST2,...
| Schlagworte: | BID1870 |
| Anwendung: | RPS6KA inhibitor |
| CAS | 501437-28-1 |
| MW: | 391,4 D |
ab 139,00 €