Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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SD-169
Artikelnummer: SYN-1079-M001
Soluble in DMSO or ethanol. SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM). Target: MAPK - p38 , Kinase Group: CMGC , Substrate:...
| Schlagworte: | SD169 |
| Anwendung: | p38 alpha inhibitor |
| CAS | 1670-87-7 |
| MW: | 160,2 D |
ab 77,00 €
SR3677
Artikelnummer: SYN-1083-M001
Soluble in DMSO. SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow...
| Schlagworte: | SR-3677 |
| Anwendung: | ROCK2 inhibitor |
| CAS | 1072959-67-1 |
| MW: | 408,5 D |
ab 154,00 €
Tandutinib
Artikelnummer: SYN-1088-M001
Soluble in DMSO or ethanol. Tandutinib inhibits the auto-phosphorylation of FLT3 (FMS-Like Tyrosine kinase-3, IC(50) of 0.22µM), c-KIT and PDGF (platelet-derived growth factor), thereby inhibiting cellular proliferation and inducing apoptosis. Target: PDGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | CT53518, MLN518 |
| Anwendung: | FLT3 / PDGFR /c-KIT inhibitor |
| CAS | 387867-13-2 |
| MW: | 562,7 D |
ab 77,00 €
GNE-493
Artikelnummer: SYN-1115-M001
Soluble in DMSO. GNE-493 is a potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor for the treatment of cancer. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | GNE493 |
| Anwendung: | PI3K inhibitor |
| CAS | 1033735-94-2 |
| MW: | 372,4 D |
ab 293,00 €
R406
Artikelnummer: SYN-1121-M001
Soluble in DMSO or ethanol. R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3. Target: Syk , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | R-406 |
| Anwendung: | Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470,5 D |
ab 154,00 €
S6K-18
Artikelnummer: SYN-1132-M001
Soluble in DMSO. S6K-18 is a highly selective inhibitor of S6K1, with an IC(50) of 52nM. Target: S6K , Kinase Group: AGC , Substrate: Serine-Threonine
| Schlagworte: | S6K18 |
| Anwendung: | S6K inhibitor |
| CAS | 1265789-88-5 |
| MW: | 358,4 D |
ab 293,00 €
BMS-540215
Artikelnummer: SYN-1134-M001
Soluble in DMSO or ethanol. BMS-540215 is an ATP-competitive inhibitor of human VEGFR-2, with an IC(50) of 25nM and Ki of 26nM. BMS-540215 also showed good selectivity for FGFR-1 (IC(50) of 48nM), FGFR-2 (IC(50) of 125nM), and FGFR-3 (IC(50) of 68nM). Target: FGFR - VEGFR2 , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | Brivanib, BMS540215 |
| Anwendung: | VEGFR-2 / FGFR inhibitor |
| CAS | 649735-46-6 |
| MW: | 370,4 D |
ab 154,00 €
Brivanib alinate
Artikelnummer: SYN-1135-M001
Soluble in DMSO or ethanol. Brivanib inhibitors VEGFR -2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM. Target: FGFR - VEGFR ,...
| Schlagworte: | BMS-582664 |
| Anwendung: | VEGFR-2 / FGFR inhibitor |
| CAS | 649735-63-7 |
| MW: | 441,5 D |
ab 223,00 €
NIBR-17
Artikelnummer: SYN-1145-M001
Soluble in DMSO. NIBR-17 is a pan class I PI3K inhibitor with IC(50) values of 1, 9.2, 9 and 20nM, respectively for PI3Kalpha - delta. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | NIBR17 |
| Anwendung: | PI3K inhibitor |
| CAS | 944396-88-7 |
| MW: | 380,4 D |
ab 262,00 €
NVP-BGJ398
Artikelnummer: SYN-1152-M001
Soluble in DMSO or ethanol. NVP-BGJ398 inhibits FGFR-WT, FGFR2-WT, FGFR3-K650E, FGFR3-S249C and FGFR4-WT with IC(50) values of 4.6, 4.9, 5, 5 and 168nM, respectively. Target: FGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | NVPBGJ398 |
| Anwendung: | FGFR inhibitor |
| CAS | 872511-34-7 |
| MW: | 560,5 D |
ab 92,00 €
PP-242
Artikelnummer: SYN-1181-M001
Soluble in DMSO or ethanol. PP242 exhibits potent selectivity for mTOR over other PI3K family kinases such as p110 alpha - delta and DNA-PK, with IC(50) of 1.96µM, 2.2µM, 1.27µM, 0.102µM, and 0.408µM, respectively.
| Schlagworte: | PP242 |
| Anwendung: | mTOR inhibitor |
| CAS | 1092351-67-1 |
| MW: | 308,3 D |
ab 77,00 €
MPI-0479605
Artikelnummer: SYN-1187-M001
Soluble in DMSO. MPI-0479605 inhibits TTK kinase activity in vitro with an IC(50) of 4nM.
| Schlagworte: | MPI0479605 |
| Anwendung: | TTK inhibitor |
| CAS | 1246529-32-7 |
| MW: | 444,0 D |
ab 293,00 €