Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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AT7519 hydrochloride
Artikelnummer: SYN-1010-M001
Soluble in DMSO or ethanol. AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519...
| Schlagworte: | AT-7519 |
| Anwendung: | CDK2 / CDK7 / CDK5 / CDK4 inhibitor |
| CAS | 902135-91-5 |
| MW: | 418,7 D |
ab 92,00 €
Tivozanib
Artikelnummer: SYN-1013-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Tivozanib is a potent inhibitor of VEGFR-1, 2 & 3 (IC(50) 0.21, 0.16 and 0.24nM respectively). Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | AV-951 |
| Anwendung: | VEGFR inhibitor |
| CAS | 475108-18-0 |
| MW: | 454,9 D |
ab 123,00 €
BMS-2
Artikelnummer: SYN-1022-M001
Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water. BMS-2 is a potent MET kinase inhibitor with an IC(50) value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC(50) values of 4nM and 27nM respectively. Target: MET , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | BMS2 |
| Anwendung: | MET inhibitor |
| CAS | 888719-03-7 |
| MW: | 458,4 D |
ab 385,00 €
E-7080
Artikelnummer: SYN-1038-M001
Soluble in DMSO or ethanol. E7080 is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. It is most potent against VEGFR2(KDR)/VEGFR3(Flt-4), with IC(50) values of 4nM and 5.2nM respectively. Target: FGFR - VEGFR - SCF , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | E-7080 |
| Anwendung: | VEGFR2 /VEGFR3 inhibitor |
| CAS | 417716-92-8 |
| MW: | 426,9 D |
ab 139,00 €
JNJ-38877605
Artikelnummer: SYN-1047-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229...
| Schlagworte: | JNJ38877605 |
| Anwendung: | c-MET inhibitor |
| CAS | 943540-75-8 |
| MW: | 377,4 D |
ab 139,00 €
JNJ-7706621
Artikelnummer: SYN-1048-M001
Soluble in DMSO or ethanol. JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDK) and aurora kinases. It demonstrates highest potency on CDK1/2 with IC(50) values of 9nM and 4nM respectively. It shows more than 6-fold selectivity for CDK1/2 over CDK3/4/6. Target: Aurora - CDK , Kinase Group: Other ,...
| Schlagworte: | JNJ7706621 |
| Anwendung: | Aurora / CDK1 / CDK2 inhibitor |
| CAS | 443797-96-4 |
| MW: | 394,4 D |
ab 193,00 €
Nilotinib
Artikelnummer: SYN-1057-M001
Soluble in DMSO or ethanol. Nilotinib is an orally bio-available aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor (IC(50) <30nM) with anti-neoplastic activity. Target: Abl - PDGFR - BCR , Kinase Group: RTK, PTK , Substrate: Tyrosine
| Schlagworte: | AMN107, Tasigna |
| Anwendung: | Bcr-Abl / PDGFR inhibitor |
| CAS | 641571-10-0 |
| MW: | 529,5 D |
ab 77,00 €
PF-562271
Artikelnummer: SYN-1064-M001
Soluble in DMSO or ethanol. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was...
| Schlagworte: | PF562271, PF-562,271 |
| Anwendung: | FAK / Pyk2 inhibitor |
| CAS | 717907-75-0 |
| MW: | 507,5 D |
ab 123,00 €
PIK-93
Artikelnummer: SYN-1066-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PIK-93 selectively inhibits the type III PI 4-kinase beta enzyme (IC(50) of 19nM). It has also been shown to have activity on PI3Kalpha with an IC(50) of 39nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | PIK93 |
| Anwendung: | PI4KB inhibitor |
| CAS | 593960-11-3 |
| MW: | 389,9 D |
ab 162,00 €
PIK-90
Artikelnummer: SYN-1068-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. PIK-90 is a potent PI3K inhibitor with IC(50) values of 11, 18, and 58nM for p110alpha, gamma and delta isoforms respectively. It has an IC(50) of 350nM for the p110beta isoform. It also has low mTOR activity. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | PIK90 |
| Anwendung: | PI3K inhibitor |
| CAS | 677338-12-4 |
| MW: | 351,4 D |
ab 77,00 €
Purvalanol B
Artikelnummer: SYN-1070-M001
Soluble in DMSO or ethanol. Purvalanol B is a cyclin-dependent kinase inhibitor with IC(50) values of 6, 6, 9, > 10,000, and 6nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35, respectively. Purvalanol B has also been shown to have anti-proliferative properties, mediated by p42/p44...
| Schlagworte: | NG95 |
| Anwendung: | Cyclin-dependent kinase inhibitor inhibitor |
| CAS | 212844-54-7 |
| MW: | 432,9 D |
ab 77,00 €
RWJ-67657
Artikelnummer: SYN-1072-M001
Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...
| Schlagworte: | RWJ67657 |
| Anwendung: | p38 inhibitor |
| CAS | 215303-72-3 |
| MW: | 425,5 D |
ab 77,00 €