Produkte von SYNkinase
SYNkinase mit Hauptsitz in Australien ist ein führender Hersteller von biomedizinischen Reagenzien für Forschungszwecke. Die Produkte zielen auf die Bedürfnisse von Forschern aus der Life-Science- und Arzneimittelforschung an Universitäten, Forschungsinstituten und in der Industrie. SYNkinase wurde 2008 von Professor Andrew Wilks und Dr. Bu Xian gegründet. Die Gründer der Firma sind seit drei Jahrzehnten in der pharmazeutischen Wirkstoffforschung tätig und verfügen über umfangreiche Erfahrung in der Wissenschaft und in Unternehmensvorständen.
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XL-388
Artikelnummer: SYN-1186-M001
Soluble in DMSO. XL388 is a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR) with an IC(50) of 9.9nM.
| Schlagworte: | XL-388 |
| Anwendung: | mTOR inhibitor |
| CAS | 1251156-08-7 |
| MW: | 455,5 D |
ab 239,00 €
LY-2784544
Artikelnummer: SYN-1196-M001
Soluble in DMSO or ethanol. LY2784544 is a potent JAK2 inhibitor with IC(50) of 3nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | LY-2784544 |
| Anwendung: | JAK2 inhibitor |
| CAS | 1229236-86-5 |
| MW: | 469,9 D |
ab 139,00 €
PRT-060318
Artikelnummer: SYN-1204-M001
Soluble in DMSO. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model. Target: Syk , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | PRT060318 |
| Anwendung: | Syk inhibitor |
| CAS | 1194961-19-7 |
| MW: | 340,4 D |
ab 231,00 €
BIX02565
Artikelnummer: SYN-1228-M001
Solid. Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water. TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC(50) of 2.4nM.
| Schlagworte: | TAK632 |
| Anwendung: | pan-RAF inhibitor |
| CAS | 1311367-27-7 |
| MW: | 554,5 D |
ab 139,00 €
GSK-J1
Artikelnummer: SYN-3030-M001
GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other...
| Schlagworte: | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine |
| Anwendung: | H3K27 histone demethylase JMJD3 (KDM6B) / UTX (KDM6A) inhibitor |
| CAS | 1373422-53-7 |
| MW: | 389.5 D |
ab 92,00 €
PFI-4
Artikelnummer: SYN-3047-M001
Potent and selective BRPF1 bromodomain inhibitor, with an IC50 of 80nM. PFI-4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. PFI-4 specifically binds to the bromodomain of BRPF1 (Kd = 13nM), inhibiting binding to tri-acetylated histone 4 (residues...
| Schlagworte: | N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
| Anwendung: | Potent,selective BRPF1 bromodomain inhibitor |
| CAS | 900305-37-5 |
| MW: | 380.5 D |
ab 77,00 €
XD14
Artikelnummer: SYN-3048-M001
BET bromodomain inhibitor with Kd values of 160, 170, 380, 490, 830 and 850nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively. XD14 also inhibits BRDT(1), CBP, p300 and BRDT(2) with Kd values of 1.2, 1.6, 2.6 and 3.7µM, respectively. XD14 has shown to attenuate proliferation of HL-60...
| Schlagworte: | 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide |
| Anwendung: | BET bromodomain inhibitor |
| CAS | 1370888-71-3 |
| MW: | 421.5 D |
ab 108,00 €
Quizartinib
Artikelnummer: SYN-1003-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Quizartinib (AC220) is a second-generation FLT3 inhibitor that has shown promising activity in AML in Phase II clinical trials. It inhibits mutant and wild-type FLT3 in vivo at 0.1 and 0.5µM, respectively, and has shown favorable activity and tolerability in...
| Schlagworte: | AC220 |
| Anwendung: | FLT3 inhibitor |
| CAS | 950769-58-1 |
| MW: | 560,7 D |
ab 139,00 €
AG13958
Artikelnummer: SYN-1004-M001
Soluble in DMSO. AG13958 is a VEGF inhibitor that was in clinical development for treatment of age-related macular degeneration (AMD). The drug displays low water solubility and so far in trials delivery has been difficult needing direct injection to be truly effective and it varied by the species used because of...
| Schlagworte: | AG-13958 |
| Anwendung: | FLT/TYK receptor inhibitor |
| CAS | 319460-94-1 |
| MW: | 467,5 D |
ab 385,00 €
Akt-I-2 hydrochloride
Artikelnummer: SYN-1006-M001
Soluble in DMSO. The compound (Akt-I-2) inhibited both Akt1 and Akt2 with IC(50) values of 2.7 and 21 µM respectively. It does not inhibit AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 and...
| Schlagworte: | AktI2 |
| Anwendung: | Akt1 / Akt2 inhibitor |
| CAS | 473382-50-2 |
| MW: | 375,9 D |
ab 300,00 €
AMG-Tie2-1
Artikelnummer: SYN-1008-M001
Soluble in DMSO. AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC(50) <1nM). Target: Tie-2 , Kinase Group: RTK , Substrate: Tyrosine
| Schlagworte: | AMGTie2-1 |
| Anwendung: | TEK inhibitor |
| CAS | 870223-96-4 |
| MW: | 479,5 D |
ab 300,00 €
AS-252424
Artikelnummer: SYN-1009-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AS-252424 is a potent and selective PI3K inhibitor. It inhibits human recombinant PI3K alpha, beta, gamma and delta with IC(50) values of 30, 940, 20.000, and 20.000nM respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | AS252424 |
| Anwendung: | PI3K inhibitor |
| CAS | 900515-16-4 |
| MW: | 305,3 D |
ab 100,00 €