Zu "K21289" wurden 44 Artikel gefunden!
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PI3-Kinase Inhibitor
Artikelnummer: Cay43486-1
PI3-Kinase inhibitor is an inhibitor of PI3Kgamma (IC50 = 1.5 nM). It is selective for PI3Kgamma over PI3Kalpha, PI3Kbeta, and PI3Kdelta (IC50s = 3,333, >10,000, and >1,000 nM, respectively). PI3-Kinase inhibitor (100 mg/kg) inhibits tumor growth in a 4T1 murine mammary cancer model. It decreases disease severity in...
| Schlagworte: | Phosphatidylinositol 3-Kinase Inhibitor, PI3K Inhibitor,... |
| Anwendung: | PI3Kgamma inhibitor |
| CAS | 2504036-13-7 |
| MW: | 441.55 D |
ab 40,00 €
IPI-549
Artikelnummer: Cay26416-1
IPI-549 is an inhibitor of PI3Kgamma (IC50s = 16, 3,200, 3,500, and >8,400 nM for PI3Kgamma, PI3Kalpha, PI3Kbeta, and PI3Kdelta, respectively). It is greater than 100-fold selective for PI3Kgamma over a panel of 468 mutant and nonmutant protein and lipid kinases, including Class II PI3K isoforms, and a panel of 80 G...
| Schlagworte: | 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-pyrazolo[1,5-... |
| Anwendung: | PI3Kgamma inhibitor |
| CAS | 1693758-51-8 |
| MW: | 528.6 D |
ab 57,00 €
PI3 kinase (p120g), active human recombinant protein
Artikelnummer: BPS-40625
Active human p120gamma ( GenBank Accession No. AF327656), full length with N-terminal His tag, MW=131 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PIK3CG, p110gamma, p120-PI3K, PI3Kgamma, PI3K-gamma, PI3-kinase subunit gamma, PtdIns-3-kinase subunit gamma,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 131 kD |
655,00 €
Anti-PIK3CG
Artikelnummer: E-AB-13516.120
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell...
| Schlagworte: | Anti-PIK3CG, Anti-PI3Kgamma, Anti-p110gamma, Anti-p120-PI3K, Anti-PI3K-gamma, EC=2.7.11.1, EC=2.7.1.153, Anti-PI3-kinase... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
CH5132799
Artikelnummer: Cay26410-50
CH5132799 is an inhibitor of class I PI3K isoforms (IC50s = 14, 120, 500, and 36 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, and PI3Kgamma, respectively). It is selective for these PI3K isoforms over PI3KC2alpha and PI3KC2beta, which are class II PI3Ks, Vps34, a class III PI3K, and mTOR (IC50s = 5,300, >10,000, >10,000,...
| Schlagworte: | 5-[6,7-dihydro-7-(methylsulfonyl)-2-(4-morpholinyl)-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-pyrimidinamine |
| Anwendung: | PI3K alpha / beta / delta / gamma inhibitor |
| CAS | 1007207-67-1 |
| MW: | 377.4 D |
ab 304,00 €
IPI-549
Artikelnummer: LKT-I611325.100
Selective inhibitor of the gamma isoform of PI3K (PI3Kgamma).
| Schlagworte: | IPI 549, IPI549 |
| Anwendung: | PI3Kgamma inhibitor |
| CAS | 1693758-51-8 |
| MW: | 528.58 D |
ab 180,00 €
PI3Kgamma (p110gamma/PIK3R5) Assay Kit
Artikelnummer: BPS-79803
The PI3Kgamma (p110gamma/PIK3R5) Assay Kit is designed to measure PI3Kgamma activity for screening and profiling applications, using ADP-Glo(R) Kinase Assay as a detection reagent.
| Schlagworte: | PIK3CG, p110gammaPIK3R5, phosphoinositide-3-kinase regulatory subunit 5, FOAP2, |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
PKI-402
Artikelnummer: Cay27664-5
PKI-402 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR, IC50s = 1.4, 9.2, and 1.7 nM for PI3Kalpha, PI3Kgamma, and mTOR, respectively). It reduces proliferation of MDA-MB-361 and PC3 cancer cells (IC50s = 8 and 21 nM, respectively) and inhibits phosphorylation of Akt in MDA-MB-361 cells (IC50 =...
| Schlagworte: | N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phe... |
| Anwendung: | PI3K, mTOR dual inhibitor |
| CAS | 1173204-81-3 |
| MW: | 570.6 D |
ab 89,00 €
Voxtalisib
Artikelnummer: Cay30323-10
Voxtalisib is a dual inhibitor of PI3K and mammalian target of rapamycin complex (mTORC, IC50s = 39, 110, 43, 9, 160, and 910 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, mTORC1, and mTORC2, respectively). It is selective for these kinases over vacuolar protein sorting 34 (VPS34, IC50 = 9,100 nM) and a panel of...
| Schlagworte: | SAR245409, XL765, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Anwendung: | mTORC / PI3K dual inhibitor |
| CAS | 934493-76-2 |
| MW: | 270.3 D |
ab 180,00 €
Anti-PI3K gamma / PIK3CG
Artikelnummer: NSJ-RQ5751
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene. Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein...
| Schlagworte: | Anti-PIK3CG, Anti-p120-PI3K, Anti-PI3Kgamma, Anti-p110gamma, Anti-PI3K-gamma, EC=2.7.11.1, Anti-PI3-kinase subunit gamma,... |
| Anwendung: | WB, IHC (paraffin), FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-PIK3CG / p110 gamma
Artikelnummer: ARG43223.100
Protein function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling...
| Schlagworte: | Anti-PIK3CG, Anti-PI3Kgamma, Anti-p110gamma, Anti-p120-PI3K, Anti-PI3Kgamma, Anti-p110gamma, Anti-p120-PI3K,... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
PI3K p110gamma (human, recombinant)
Artikelnummer: Cay33989-20
Class I phosphatidylinositol 3-kinases (PI3Ks) are membrane-associated lipid kinases with roles in membrane trafficking during autophagy, endosome recycling, and endocytosis, adaptive and innate immune cell activation, and leukocyte chemotaxis, as well as various diseases. They are heterodimeric enzymes composed of...
| Schlagworte: | PIK3CG, PI3Kgamma, p110gamma, p120-PI3K, PI3Kgamma, p110gamma, p120-PI3K, PI3K-gamma, PI3K-gamma, PI3-kinase subunit... |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
699,00 €