Zu "K21289" wurden 45 Artikel gefunden!
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PI3-Kinase Inhibitor
Artikelnummer: Cay43486-1
PI3-Kinase inhibitor is an inhibitor of PI3Kgamma (IC50 = 1.5 nM). It is selective for PI3Kgamma over PI3Kalpha, PI3Kbeta, and PI3Kdelta (IC50s = 3,333, >10,000, and >1,000 nM, respectively). PI3-Kinase inhibitor (100 mg/kg) inhibits tumor growth in a 4T1 murine mammary cancer model. It decreases disease severity in...
| Schlagworte: | Phosphatidylinositol 3-Kinase Inhibitor, PI3K Inhibitor,... |
| Anwendung: | PI3Kgamma inhibitor |
| CAS | 2504036-13-7 |
| MW: | 441.55 D |
ab 38,00 €
TG 100-115
Artikelnummer: Cay10010512-1
TG 100-115 is an inhibitor of PI3Kgamma and PI3Kdelta (IC50s = 0. and 0. µM, respectively). It is selective for PI3Kgamma and PI3Kdelta over PI3Kalpha and PI3Kbeta (IC50s = 1. and 1. µM) and a panel of 140 additional kinases but does inhibit eight kinases in the panel. TG 100-115 also inhibits the kinase activity of...
| Schlagworte: | 3,3'-(2,4-diamino-6,7-pteridinediyl)bis-phenol |
| Anwendung: | PI3Kgamma/PI3Kdelta inhibitor |
| CAS | 677297-51-7 |
| MW: | 346.3 D |
ab 38,00 €
IPI-549
Artikelnummer: Cay26416-1
IPI-549 is an inhibitor of PI3Kgamma (IC50s = 16, 3,200, 3,500, and >8,400 nM for PI3Kgamma, PI3Kalpha, PI3Kbeta, and PI3Kdelta, respectively). It is greater than 100-fold selective for PI3Kgamma over a panel of 468 mutant and nonmutant protein and lipid kinases, including Class II PI3K isoforms, and a panel of 80 G...
| Schlagworte: | 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-pyrazolo[1,5-... |
| Anwendung: | PI3Kgamma inhibitor |
| CAS | 1693758-51-8 |
| MW: | 528.6 D |
ab 54,00 €
PI3 kinase (p120g), active human recombinant protein
Artikelnummer: BPS-40625
Active human p120gamma ( GenBank Accession No. AF327656), full length with N-terminal His tag, MW=131 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PIK3CG, p110gamma, p120-PI3K, PI3Kgamma, PI3K-gamma, PI3-kinase subunit gamma, PtdIns-3-kinase subunit gamma,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 131 kD |
655,00 €
Anti-PIK3CG
Artikelnummer: E-AB-13516.120
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell...
| Schlagworte: | Anti-PIK3CG, Anti-PI3Kgamma, Anti-p110gamma, Anti-p120-PI3K, Anti-PI3K-gamma, EC=2.7.11.1, EC=2.7.1.153, Anti-PI3-kinase... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
CH5132799
Artikelnummer: Cay26410-50
CH5132799 is an inhibitor of class I PI3K isoforms (IC50s = 14, 120, 500, and 36 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, and PI3Kgamma, respectively). It is selective for these PI3K isoforms over PI3KC2alpha and PI3KC2beta, which are class II PI3Ks, Vps34, a class III PI3K, and mTOR (IC50s = 5,300, >10,000, >10,000,...
| Schlagworte: | 5-[6,7-dihydro-7-(methylsulfonyl)-2-(4-morpholinyl)-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-pyrimidinamine |
| Anwendung: | PI3K alpha / beta / delta / gamma inhibitor |
| CAS | 1007207-67-1 |
| MW: | 377.4 D |
ab 294,00 €
IPI-549
Artikelnummer: LKT-I611325.100
Selective inhibitor of the gamma isoform of PI3K (PI3Kgamma).
| Schlagworte: | IPI 549, IPI549 |
| Anwendung: | PI3Kgamma inhibitor |
| CAS | 1693758-51-8 |
| MW: | 528.58 D |
ab 180,00 €
PI3Kgamma (p110gamma/PIK3R5) Assay Kit
Artikelnummer: BPS-79803
The PI3Kgamma (p110gamma/PIK3R5) Assay Kit is designed to measure PI3Kgamma activity for screening and profiling applications, using ADP-Glo(R) Kinase Assay as a detection reagent.
| Schlagworte: | PIK3CG, p110gammaPIK3R5, phosphoinositide-3-kinase regulatory subunit 5, FOAP2, |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
842,00 €
PKI-402
Artikelnummer: Cay27664-5
PKI-402 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR, IC50s = 1.4, 9.2, and 1.7 nM for PI3Kalpha, PI3Kgamma, and mTOR, respectively). It reduces proliferation of MDA-MB-361 and PC3 cancer cells (IC50s = 8 and 21 nM, respectively) and inhibits phosphorylation of Akt in MDA-MB-361 cells (IC50 =...
| Schlagworte: | N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phe... |
| Anwendung: | PI3K, mTOR dual inhibitor |
| CAS | 1173204-81-3 |
| MW: | 570.6 D |
ab 85,00 €
Voxtalisib
Artikelnummer: Cay30323-10
Voxtalisib is a dual inhibitor of PI3K and mammalian target of rapamycin complex (mTORC, IC50s = 39, 110, 43, 9, 160, and 910 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, mTORC1, and mTORC2, respectively). It is selective for these kinases over vacuolar protein sorting 34 (VPS34, IC50 = 9,100 nM) and a panel of...
| Schlagworte: | SAR245409, XL765, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Anwendung: | mTORC / PI3K dual inhibitor |
| CAS | 934493-76-2 |
| MW: | 270.3 D |
ab 174,00 €
Anti-PI3K gamma / PIK3CG
Artikelnummer: NSJ-RQ5751
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene. Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein...
| Schlagworte: | Anti-PIK3CG, Anti-p120-PI3K, Anti-PI3Kgamma, Anti-p110gamma, Anti-PI3K-gamma, EC=2.7.11.1, Anti-PI3-kinase subunit gamma,... |
| Anwendung: | WB, IHC (paraffin), FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-PIK3CG / p110 gamma
Artikelnummer: ARG43223.100
Protein function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling...
| Schlagworte: | Anti-PIK3CG, Anti-PI3Kgamma, Anti-p110gamma, Anti-p120-PI3K, Anti-PI3Kgamma, Anti-p110gamma, Anti-p120-PI3K,... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €