Zu "K20996" wurden 27 Artikel gefunden!
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Notch 4, His, Mouse
Artikelnummer: GSC-Z06287-100
The Notch signaling pathway is important for cell-cell communication, it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression correlates with Ki67. Notch-4 also plays a key role in breast cancer stem-like cells.
| Schlagworte: | Notch4, Neurogenic locus notch homolog protein 4 |
| Ursprungsart: | mouse |
| MW: | 42.91 kD |
ab 457,00 €
FLI-06
Artikelnummer: Cay21272-5
FLI-06 is a first-of-its-kind inhibitor of Notch signaling (EC50 = 2.3 µM) that acts upstream of alpha-secretase and beta-secretase cleavage. It disrupts the intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage before exit from the endoplasmic reticulum...
| Schlagworte: | 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid, cyclohexyl ester |
| Anwendung: | Notch signaling inhibitor |
| CAS | 313967-18-9 |
| MW: | 438.5 D |
ab 122,00 €
Human NOTCH4 ELISA Kit
Artikelnummer: G-HUFI01880.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-NOTCH4
Artikelnummer: NSJ-R30929
0.5mg/ml if reconstituted with 0.2ml sterile DI water. NOTCH4 is a member of the Notch family. In situ hybridization revealed that Notch4 transcripts are primarily restricted to endothelial cells in embryonic and adult life, suggesting a specific role for the protein during development of vertebrate endothelium. The...
| Schlagworte: | Anti-INT3, Anti-NOTCH4, NOTCH4 Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
FLI-06
Artikelnummer: LKT-F4432.1
Dihydropyridine, gamma-secretase inhibitor.
| Schlagworte: | 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester |
| Anwendung: | Dihydropyridine, gamma-secretase inhibitor |
| CAS | 313967-18-9 |
| MW: | 438.52 D |
ab 87,00 €
Anti-NOTCH4
Artikelnummer: NSJ-F53420-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates...
| Schlagworte: | Anti-INT3, Anti-NOTCH4, NOTCH4 Antibody |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
Anti-Notch 4
Artikelnummer: ARG58768.100
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...
| Schlagworte: | Anti-INT3 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
707,00 €
Anti-NOTCH4
Artikelnummer: E-AB-53286.120
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch...
| Schlagworte: | Anti-INT3, NOTCH4 Polyclonal Antibody |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
CB-103
Artikelnummer: Cay36293-500
CB-103 is an inhibitor of Notch signaling. It binds to the b-trefoil domain (BTD) of recombination signal binding protein for immunoglobulin kappa J region (RBPJ) and inhibits the assembly of the RBPJ-Notch intracellular domain (NICD) transcription complex. CB-103 inhibits ligand-induced Notch signaling in HeLa...
| Schlagworte: | 6-[4-(1,1-dimethylethyl)phenoxy]-3-pyridinamine |
| Anwendung: | Notch signaling inhibitor |
| CAS | 218457-67-1 |
| MW: | 242.3 D |
ab 49,00 €
IMR-1A
Artikelnummer: Cay37432-5
IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Cay-27920). It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and...
| Schlagworte: | 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl],phenoxy]-acetic acid |
| Anwendung: | Notch ternary complex formation inhibitor |
| CAS | 331862-41-0 |
| MW: | 325.4 D |
ab 92,00 €
Anti-Cleaved-NOTCH4 (V1432)
Artikelnummer: CSB-PA020146.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-INT3, FLJ16302 antibody, hNotch 4 antibody, hNotch4 antibody, INT3 antibody, Neurogenic locus notch homolog protein 4... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, monkey |
ab 126,00 €
Anti-NOTCH4
Artikelnummer: CSB-PA995547.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: NOTCH4. Antigen Species: Human
| Schlagworte: | Anti-INT3, FLJ16302 antibody, hNotch 4 antibody, hNotch4 antibody, INT3 antibody, Neurogenic locus notch homolog protein 4... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €