Zu "K18529" wurden 21 Artikel gefunden!
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APS-2-79 (hydrochloride)
Artikelnummer: Cay22137-5
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR). It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes. APS-2-79 (5 µM) inhibits KSR-stimulated...
| Schlagworte: | 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)-4-quinazolinamine, monohydrochloride |
| Anwendung: | KSR-dependent MAPK signaling modulator |
| CAS | 2002381-31-7 |
| MW: | 423.9 D |
ab 50,00 €
Human KSR2 ELISA Kit
Artikelnummer: G-HUFI01627.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Mouse KSR2 ELISA Kit
Artikelnummer: G-MOFI00490.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
Anti-KSR2
Artikelnummer: ATA-HPA035536.100
Protein function: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF, upon binding to MAP2K1/MEK1, dimerizes with BRAF and...
| Schlagworte: | Anti-KSR2, Anti-hKSR2, Anti-Kinase suppressor of Ras 2 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
Anti-KSR2
Artikelnummer: CSB-PA581207.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-KSR2, Anti-hKSR2, Anti-Kinase suppressor of Ras 2, FLJ25965 antibody, hKSR 2 antibody, hKSR2 antibody, Kinase... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
284,00 €
APS-2-79 hydrochloride
Artikelnummer: TGM-T6760-100mg
Description: APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. Target: MEK, MAPK. Smiles:...
| Schlagworte: | APS-2-79, APS-2-79 HCl |
| Anwendung: | KSR-dependent MAPK signaling modulator |
| CAS | 2002381-31-7 |
| MW: | 423.89 D |
ab 36,00 €
Anti-KSR2
Artikelnummer: ABS-KC-32124.100
Protein function: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF, upon binding to MAP2K1/MEK1, dimerizes with BRAF and...
| Schlagworte: | Anti-KSR2, Anti-hKSR2, Anti-Kinase suppressor of Ras 2 |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
KSR2 (human), recombinant protein
Artikelnummer: ABS-PP-6362-L.100
Protein function: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF, upon binding to MAP2K1/MEK1, dimerizes with BRAF and...
| Schlagworte: | Kinase suppressor of Ras 2, hKSR2, Recombinant Human KSR2 Protein |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 22.5 kD |
ab 115,00 €
Anti-KSR2, CT (KSR2, Kinase suppressor of Ras 2)
Artikelnummer: 037646.200
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Applications: Suitable for use in Western Blot,...
| Schlagworte: | Anti-KSR2, Anti-hKSR2, EC=2.7.11.1, Anti-Kinase suppressor of Ras 2 |
| Anwendung: | ELISA, FC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
865,00 €
Anti-Ksr2, CT (Ksr2, Kinase suppressor of Ras 2)
Artikelnummer: 037647.200
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production (By similarity). Applications: Suitable for use in...
| Schlagworte: | Anti-Ksr2, EC=2.7.11.1, Anti-Kinase suppressor of Ras 2 |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
865,00 €
KSR2 BioAssay(TM) ELISA Kit
Artikelnummer: 472485.96
Sample Type:, Cell line of choice, Intended Use: The KSR2 Colorimetric Cell-Based ELISA allows for qualitative detection of KSR2 in plated and fixed cells. Sensitivity: >5000cells/well, Assay Time: 4.5 hours, Reactivity: Human, Mouse, Detection Method: Colorimetric 450 nm, Format: Cell-Based ELISA, Storage and...
| Schlagworte: | KSR2, hKSR2, Kinase suppressor of Ras 2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
920,00 €
KSR2 PrEST Antigen
Artikelnummer: ATA-APrEST80470.100
Protein function: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF, upon binding to MAP2K1/MEK1, dimerizes with BRAF and...
| Schlagworte: | KSR2, hKSR2, Kinase suppressor of Ras 2 |
| Anwendung: | Control antigen |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
264,00 €