Zu "K17816" wurden 36 Artikel gefunden!
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TH287
Artikelnummer: Cay18132-1
Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell...
| Schlagworte: | 6-(2,3-dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine |
| Anwendung: | MTH1 inhibitor |
| CAS | 1609960-30-6 |
| MW: | 269.1 D |
ab 67,00 €
TH588
Artikelnummer: Cay18133-1
Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH588 is an MTH1 inhibitor (IC50 = 5 nM) with improved metabolic stability over...
| Schlagworte: | N4-cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine |
| Anwendung: | MTH1 inhibitor |
| CAS | 1609960-31-7 |
| MW: | 295.2 D |
ab 49,00 €
(S)-Crizotinib
Artikelnummer: Cay31114-1
(S)-Crizotinib is an inhibitor of muT homolog 1 (MTH1, IC50 = 72 nM). It is selective for MTH1 over a panel of 456 kinases at 1 µM. (S)-Crizotinib (30 µM) induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 human gastric cancer cells. It inhibits proliferation in a panel of 14 cancer cell lines...
| Schlagworte: | 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Anwendung: | MTH1 inhibitor |
| CAS | 1374356-45-2 |
| MW: | 450.3 D |
ab 50,00 €
Anti-MTH1, clone 3B3
Artikelnummer: ARG57149.50
Protein function: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently...
| Schlagworte: | Anti-MTH1, Anti-NUDT1, EC=3.6.1.56, EC=3.6.1.55, Anti-8-oxo-dGTPase, Anti-Nudix motif 1, Anti-2-hydroxy-dATP... |
| Anwendung: | WB, FC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
518,00 €
Human MTH1 / NUDT1 ELISA Kit
Artikelnummer: G-HUFI01913.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
SCH 51344
Artikelnummer: Cay17804-10
SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts. At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on...
| Schlagworte: | Ras/Rac Transformaton Blocker, 2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]-ethanol |
| Anwendung: | MTH1 inhibitor, Ras-induced malignant transformation inhibitor |
| CAS | 171927-40-5 |
| MW: | 316.4 D |
ab 139,00 €
Anti-NUDT1
Artikelnummer: ATA-HPA012636.100
Protein function: Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative...
| Schlagworte: | Anti-NUDT1, Anti-8-oxo-dGTPase, Anti-Nudix motif 1, Anti-2-hydroxy-dATP diphosphatase, Anti-7,8-dihydro-8-oxoguanine... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 369,00 €
3-Isomangostin
Artikelnummer: Cay36484-1
3-Isomangostin is a xanthone and alpha-mangostin (Cay-29108) derivative that has been found in G. mangostana and has diverse biological activities. It is an inhibitor of mutT homolog 1 (MTH1, IC50 = 52 nM). 3-Isomangostin also inhibits aldose reductase (IC50 = 3.48 µM), acetylcholinesterase (AChE, IC50 = 2.36...
| Schlagworte: | 3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one |
| Anwendung: | Bioactive xanthone, MTH1 inhibitor |
| CAS | 19275-46-8 |
| MW: | 410.5 D |
ab 44,00 €
7,8-Dihydro-8-oxoguanine triphosphatase (NUDT1), human,...
Artikelnummer: CSB-BP016154HU.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC...
| Schlagworte: | NUDT1, Nudix motif 1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, Nucleoside... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 22.8 kD |
ab 375,00 €
7,8-Dihydro-8-oxoguanine triphosphatase (NUDT1), human,...
Artikelnummer: CSB-EP016154HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: Tag-Free. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE SDEMRPCWFQ...
| Schlagworte: | NUDT1, Nudix motif 1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, Nucleoside... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 20.3 kD |
ab 395,00 €
7,8-Dihydro-8-oxoguanine triphosphatase (NUDT1), human,...
Artikelnummer: CSB-YP016154HUa0.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE...
| Schlagworte: | NUDT1, Nudix motif 1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, Nucleoside... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 22.3 kD |
ab 292,00 €
TH588
Artikelnummer: TGM-T2037-100mg
Description: TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells. Target: MTH1, DNA/RNA Synthesis. Smiles: Nc1nc(NC2CC2)cc(n1)-c1cccc(Cl)c1Cl. References: Gad H, et al. Nature. 2014, 508(7495), 215-221.
| Anwendung: | MTH1 inhibitor |
| CAS | 1609960-31-7 |
| MW: | 295.17 D |
ab 34,00 €