Zu "K17816" wurden 32 Artikel gefunden!
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(S)-crizotinib
Artikelnummer: TGM-T6357-100mg
Description: (S)-crizotinib (ent-crizotinib) (IC50 of 72 nM), an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib. Target: DNA/RNA Synthesis, Apoptosis, MTH1. Smiles: C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl. References: Huber KV, et al. Nature. 2014 , 508(7495), 222-227.
| Schlagworte: | ent-crizotinib |
| Anwendung: | MTH1 inhibitor |
| CAS | 1374356-45-2 |
| MW: | 450.34 D |
ab 40,00 €
TH588
Artikelnummer: TGM-T2037-100mg
Description: TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells. Target: MTH1, DNA/RNA Synthesis. Smiles: Nc1nc(NC2CC2)cc(n1)-c1cccc(Cl)c1Cl. References: Gad H, et al. Nature. 2014, 508(7495), 215-221.
| Anwendung: | MTH1 inhibitor |
| CAS | 1609960-31-7 |
| MW: | 295.17 D |
ab 37,00 €
SCH 51344
Artikelnummer: TGM-T21676-5mg
Description: SCH 51344 inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene-transformed fibroblasts [1]. Target: Others. Smiles: COc1ccc2nc3[nH]nc(C)c3c(NCCOCCO)c2c1
| Anwendung: | MTH1 inhibitor, Ras-induced malignant transformation inhibitor |
| CAS | 171927-40-5 |
| MW: | 316.36 D |
ab 233,00 €
TH287
Artikelnummer: TGM-T2069-1mg
Description: TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16. Target: DNA/RNA Synthesis, MTH1. Smiles: CNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl. References: Gad H, et al. Nature. 2014, 508(7495), 215-221.
| Schlagworte: | TH287 hydrochloride |
| Anwendung: | MTH1 inhibitor |
| CAS | 1609960-30-6 |
| MW: | 269.13 D |
ab 31,00 €
3-Isomangostin
Artikelnummer: TGM-T2S1635-1mg
Description: 3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the...
| Anwendung: | Bioactive xanthone, MTH1 inhibitor |
| CAS | 19275-46-8 |
| MW: | 410.46 D |
ab 37,00 €
7,8-Dihydro-8-oxoguanine triphosphatase (NUDT1), human,...
Artikelnummer: CSB-BP016154HU.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC...
| Schlagworte: | NUDT1, Nudix motif 1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, Nucleoside... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 22.8 kD |
ab 375,00 €
7,8-Dihydro-8-oxoguanine triphosphatase (NUDT1), human,...
Artikelnummer: CSB-EP016154HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: Tag-Free. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE SDEMRPCWFQ...
| Schlagworte: | NUDT1, Nudix motif 1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, Nucleoside... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 20.3 kD |
ab 395,00 €
7,8-Dihydro-8-oxoguanine triphosphatase (NUDT1), human,...
Artikelnummer: CSB-YP016154HUa0.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE...
| Schlagworte: | NUDT1, Nudix motif 1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, Nucleoside... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 22.3 kD |
ab 292,00 €
TH287
Artikelnummer: Cay18132-1
Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell...
| Schlagworte: | 6-(2,3-dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine |
| Anwendung: | MTH1 inhibitor |
| CAS | 1609960-30-6 |
| MW: | 269.1 D |
ab 61,00 €
TH588
Artikelnummer: Cay18133-1
Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH588 is an MTH1 inhibitor (IC50 = 5 nM) with improved metabolic stability over...
| Schlagworte: | N4-cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine |
| Anwendung: | MTH1 inhibitor |
| CAS | 1609960-31-7 |
| MW: | 295.2 D |
ab 44,00 €
(S)-Crizotinib
Artikelnummer: Cay31114-1
(S)-Crizotinib is an inhibitor of muT homolog 1 (MTH1, IC50 = 72 nM). It is selective for MTH1 over a panel of 456 kinases at 1 µM. (S)-Crizotinib (30 µM) induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 human gastric cancer cells. It inhibits proliferation in a panel of 14 cancer cell lines...
| Schlagworte: | 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Anwendung: | MTH1 inhibitor |
| CAS | 1374356-45-2 |
| MW: | 450.3 D |
ab 45,00 €
Anti-MTH1, clone 3B3
Artikelnummer: ARG57149.50
Protein function: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently...
| Schlagworte: | Anti-MTH1, Anti-NUDT1, EC=3.6.1.56, EC=3.6.1.55, Anti-8-oxo-dGTPase, Anti-Nudix motif 1, Anti-2-hydroxy-dATP... |
| Anwendung: | WB, FC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
518,00 €