Zu "K17692" wurden 15 Artikel gefunden!
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(E)-KPT-330
Artikelnummer: Cay39562-1
(E)-KPT-330 is a metabolite of the exportin 1 (XPO1/CRM1) inhibitor selinexor. It is formed from selinexor by the cytochrome P450 (CYP) isoform CYP3A4.Formal Name: 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2E)-2-propenoic acid. CAS Number: 1421923-86-5. Synonyms:...
| Schlagworte: | trans Selinexor, KTP-330, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide,... |
| Anwendung: | Selinexor metabolite |
| CAS | 1421923-86-5 |
| MW: | 443.3 D |
ab 40,00 €
Cobicistat
Artikelnummer: Cay23433-5
Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors). It is selective for CYP3A over other CYP isomers (IC50 = >25 µM for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 µM) or affect HIV...
| Schlagworte: | GS-9350,... |
| Anwendung: | CYP3A inhibitor |
| CAS | 1004316-88-4 |
| MW: | 776 D |
ab 58,00 €
16alpha-hydroxy Prednisolone
Artikelnummer: Cay27169-5
16alpha-hydroxy Prednisolone is a metabolite of 22(R)-budesonide. It is formed from 22(R)-budesonide by the cytochrome P450 (CYP) isoform CYP3A in human liver microsomesFormal Name: (11beta,16alpha)-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione. CAS Number: 13951-70-7. Molecular Formula: C21H28O6. Formula...
| Schlagworte: | (11beta,16alpha)-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione |
| Anwendung: | 22(R)-Budesonide metabolite |
| CAS | 13951-70-7 |
| MW: | 376.4 D |
ab 51,00 €
Anti-CYP3A43
Artikelnummer: ATA-HPA066463.100
Protein function: Exhibits low testosterone 6-beta-hydroxylase activity. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 68% and to rat: 60%
| Schlagworte: | Anti-CYP3A43, EC=1.14.14.1, Anti-Cytochrome P450 3A43 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
Cytochrome P450 3A43 (CYP3A43), human, recombinant
Artikelnummer: CSB-EP862059HUb1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-393aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MDLIPNFAME TWVLVATSLV LLYIYGTHSH KLFKKLGIPG PTPLPFLGTI LFYLRRSLNK IPSWAWWLTP VIPALWEAEA GGSPKVRSSR PALPTWVFGI LTENVMKNTE...
| Schlagworte: | CYP3A43, EC=1.14.14.1, Cytochrome P450 3A43, Recombinant Human Cytochrome P450 3A43 (CYP3A43) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 52.3 kD |
ab 292,00 €
Anti-CYP3A43
Artikelnummer: CSB-PA281728.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-CYP3A43, EC=1.14.14.1, Anti-Cytochrome P450 3A43, CYP3A43Cytochrome P450 3A43 antibody, EC 1.14.14.1 antibody,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
284,00 €
(E)-KPT330
Artikelnummer: TGM-T1844-100mg
Description: (E)-KPT330 is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells. Target: CRM1, Others. Smiles: FC(F)(F)c1cc(cc(c1)C(F)(F)F)-c1ncn(\C=C\C(=O)NNc2cnccn2)n1. References: Etchin J, et al. Br J...
| Schlagworte: | (E)-RN, KPT-330, KPT330, KPT 330 |
| Anwendung: | Selinexor metabolite |
| CAS | 1421923-86-5 |
| MW: | 443.31 D |
ab 34,00 €
Anti-CYP3A43, ID (CYP3A43, Cytochrome P450 3A43)
Artikelnummer: 034436.200
CYP3A43 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein has a low level of testosterone hydroxylase activity. Although it bears...
| Schlagworte: | Anti-CYP3A43, EC=1.14.14.1, Anti-Cytochrome P450 3A43 |
| Anwendung: | ELISA, FC, IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
865,00 €
Cytochrome P450 3A43 BioAssay(TM) ELISA Kit
Artikelnummer: 471973.96
Sample Type:, Cell line of choice, Intended Use: The Cytochrome P450 3A43 Colorimetric Cell-Based ELISA allows for qualitative detection of CytochromeP4503A43 in plated and fixed cells. Sensitivity: >5000cells/well, Assay Time: 4.5 hours, Reactivity: Human, Detection Method: Colorimetric 450 nm, Format: Cell-Based...
| Schlagworte: | CYP3A43, EC=1.14.14.1, Cytochrome P450 3A43 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
920,00 €
CYP3A43 PrEST Antigen
Artikelnummer: ATA-APrEST88291.100
Protein function: Exhibits low testosterone 6-beta-hydroxylase activity. [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.
| Schlagworte: | CYP3A43, EC=1.14.14.1, Cytochrome P450 3A43 |
| Anwendung: | Control antigen |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
264,00 €
Anti-Cytochrome P450 3A43
Artikelnummer: ABD-8C12274.50
Custom conjugation services for this antibody as available (eg. labeling of Anti-Cytochrome P450 3A43 with HRP. Available labels are AF: AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750. Proteins: HRP, Alkaline Phosphatase, Streptavidin. Tandems: APC, APC/Cy7, APC/AF750, APC/iFluor(TM) 700, APC/iFluor(TM) 750,...
| Schlagworte: | Anti-CYP3A43, EC=1.14.14.1, Anti-Cytochrome P450 3A43, Cytochrome P450 3A43 Antibody |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
628,00 €
Anti-CYP3A43
Artikelnummer: CSB-PA050065.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-CYP3A43, EC=1.14.14.1, Anti-Cytochrome P450 3A43, CYP3A43Cytochrome P450 3A43 antibody, EC 1.14.14.1 antibody,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €