Zu "K15719" wurden 36 Artikel gefunden!
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TP-040
Artikelnummer: Cay41375-1
TP-040 is an O-GlcNAcase (OGA) inhibitor (IC50 = 46 nM). It is selective for OGA over beta-hexosaminidase (IC50 = >10 µM) and a panel of 277 kinases (IC50s = >1 µM for all). TP-040 increases the levels of O-GlcNAcylated proteins in SH-SY5Y neuroblastoma cells (EC50 = 450 nM).Formal Name:...
| Schlagworte: | OGA Inhibitor 1, OGA-IN-1, O-GlcNAcase Inhibitor 1, O-GlcNAcase-IN-1,... |
| Anwendung: | O-GlcNAcase (OGA) inhibitor |
| CAS | 2757254-99-0 |
| MW: | 286.4 D |
ab 35,00 €
NAG-thiazoline
Artikelnummer: TGM-T9190-100mg
Description: NAG-thiazoline (GlcNAc-thiazoline) is an O-GlcNAcase inhibitor with Ki value of 180 nM. It is active against V. campbellii with MIC value of 0.5 µM. Target: Others. Smiles: O[C@@H]1[C@@]2([C@](O[C@H](CO)[C@H]1O)(SC(C)=N2)[H])[H]. References: NAG-thiazoline is a potent inhibitor of the Vibriocampbellii...
| Schlagworte: | GlcNAc-thiazoline |
| Anwendung: | OGA inhibitor |
| CAS | 179030-22-9 |
| MW: | 219.26 D |
ab 46,00 €
Thiamet G
Artikelnummer: TGM-T6056-100mg
Description: Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, 000-fold selectivity over human lysosomal -hexosaminidase. Target: Autophagy, Others. Smiles: [H][C@]12O[C@H](CO)[C@@H](O)[C@H](O)[C@@]1([H])N=C(NCC)S2. References: Yuzwa SA, et al. Nat Chem Biol. 2008, 4(8),...
| Schlagworte: | TMG |
| Anwendung: | O-GlcNAcase inhibitor |
| CAS | 1009816-48-1 |
| MW: | 248.3 D |
ab 38,00 €
Human NAGase (N-Acetyl Beta-D-Glucosaminidase) ELISA Kit
Artikelnummer: E-EL-H0898.96
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of NAGase in serum, plasma and other biological fluids. Detection Range: 1.56--100ng/mL. Sensitivity: 0.94ng/mL. Protein function: Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc...
| Schlagworte: | OGA, HEXC, NCOAT, MGEA5, Beta-hexosaminidase, Protein O-GlcNAcase, Beta-N-acetylhexosaminidase,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
555,00 €
MK-8719
Artikelnummer: TGM-T12070-100mg
Description: MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) [hOGA], with a Ki value of 7.9 nM. Target: Others. Smiles: [H][C@]12O[C@H](C(F)F)[C@@H](O)[C@H](O)[C@@]1([H])N=C(NCC)S2. References: Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment...
| Anwendung: | O-GlcNAcase (OGA) inhibitor |
| CAS | 1382799-40-7 |
| MW: | 268.28 D |
ab 97,00 €
(Z)-PUGNAc
Artikelnummer: TGM-T38722-100mg
Description: (Z)-PUGNAc, a potent O-GlcNAcase inhibitor more active than (E)-PUGNAc, removes O-GlcNAc from proteins (peptide O-GlcNAc-beta-N-acetylaminoglucosidase) and can be used to increase levels of O-GlcNAc on nuclear and cytoplasmic proteins in vivo. Target: Others. Smiles:...
| Anwendung: | NCOAT inhibitor |
| CAS | 132489-69-1 |
| MW: | 353.33 D |
ab 65,00 €
Anti-MGEA5
Artikelnummer: CSB-PA797342.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: MGEA5. Antigen Species: Human
| Schlagworte: | Anti-OGA, Anti-HEXC, Anti-NCOAT, Anti-Beta-hexosaminidase, Anti-Protein O-GlcNAcase, Anti-Beta-N-acetylhexosaminidase,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-MGEA5
Artikelnummer: CSB-PA910720.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: MGEA5. Antigen Species: Human
| Schlagworte: | Anti-OGA, Anti-HEXC, Anti-NCOAT, Anti-Beta-hexosaminidase, Anti-Protein O-GlcNAcase, Anti-Beta-N-acetylhexosaminidase,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
MK-8719
Artikelnummer: Cay34054-1
MK-8719 is an inhibitor of O-GlcNAcase (OGA, Ki = 7.9 nM for the human enzyme). It is selective for OGA over beta-hexosaminidase (Ki = >10,000 nM for the human enzyme). MK-8719 increases the levels of O-GlcNAcylated proteins in rat PC12 adrenal medulla cells (EC50 = 52.7 nM). It increases brain levels of...
| Schlagworte: | 5S-(difluoromethyl)-2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol |
| Anwendung: | O-GlcNAcase (OGA) inhibitor |
| CAS | 1382799-40-7 |
| MW: | 268.3 D |
ab 75,00 €
Thiamet G
Artikelnummer: Cay13237-1
Hyperphosphorylation of the tau protein leads to its aggregation and formation of neurofibrillary tangles, a hallmark of Alzheimer's disease and other tauopathic, neurodegenerative disorders. Tau is also dynamically modified by the addition and cleavage of O-linked beta-N-acetylglucosamine (O-GlcNAc) moieties, which...
| Schlagworte: | 2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol |
| Anwendung: | O-GlcNAcase inhibitor |
| CAS | 1009816-48-1 |
| MW: | 248.3 D |
ab 55,00 €
(Z)-PUGNAc
Artikelnummer: Cay17151-1
Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a beta-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that...
| Schlagworte: | (1Z)-delta-lactone-2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid |
| Anwendung: | NCOAT inhibitor |
| CAS | 132489-69-1 |
| MW: | 353.3 D |
ab 44,00 €
Anti-MGEA5
Artikelnummer: A304-345A
Protein function: Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone...
| Schlagworte: | Anti-OGA, Anti-HEXC, Anti-MGEA5, Anti-NCOAT, Anti-Beta-hexosaminidase, Anti-Protein O-GlcNAcase,... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €