Zu "K14970" wurden 54 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Menin
Artikelnummer: A300-105A
Protein function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of...
| Schlagworte: | Anti-SCG2, Anti-MEN1, Anti-Menin |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
NEU
Ziftomenib
Artikelnummer: Cay45139-10
An inhibitor of the menin-MLL1 protein-protein interaction, reduces the viability of OCI-AML-3 and MV4-11 cells, reduces the viability of MOLM-13 cells expressing p53R175H and TP53-/- MOLM-13 cells over MOLM-13 cells expressing wild-type p53, increases survival in a PDX mouse model of AML at 75 mg/kg. SMILES:...
| Schlagworte: | KO-539, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]... |
| Anwendung: | Menin-MLL1 protein-protein interaction inhibitor |
| CAS | 2134675-36-6 |
| MW: | 717.88 D |
ab 438,00 €
Enzomenib
Artikelnummer: Cay44271-1
Enzomenib is an inhibitor of the protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1). It binds to menin (Kd = 6 nM) and inhibits the menin-MLL1 interaction with an IC50 value of 1. nM. Enzomenib selectively inhibits the growth of MV4-11, MOLM-13, KOPN-8, and OCI-AML-3 leukemia cells (IC50s...
| Schlagworte: | DSP-5336 |
| Anwendung: | Menin-MLL1 protein-protein interaction inhibitor |
| CAS | 2412555-70-3 |
| MW: | 590.74 D |
ab 186,00 €
MI-2 (hydrochloride)
Artikelnummer: Cay11620-1
Menin, a product of the multiple endocrine neoplasia gene, is an essential component of histone methyltransferase complexes involving the mixed lineage leukemia (MLL) gene product. Also, the leukemogenic activity of MLL fusion proteins depends on their direct interaction with menin. MI-2 potently binds menin, blocks...
| Schlagworte: | 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine, dihydrochloride |
| Anwendung: | Menin binding |
| MW: | 448.5 D |
ab 56,00 €
MI-nc (hydrochloride)
Artikelnummer: Cay11621-1
Menin, a product of the multiple endocrine neoplasia gene, is an essential component of histone methyltransferase complexes involving the mixed lineage leukemia (MLL) gene product. Also, the leukemogenic activity of MLL fusion proteins depends on their direct interaction with menin. MI-nc is a weak inhibitor of the...
| Schlagworte: | 6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]-thieno[2,3-d]pyrimidine, dihydrochloride |
| Anwendung: | Menin-MLL inhibitor, negative control |
| CAS | 1934302-23-4 |
| MW: | 405.4 D |
ab 93,00 €
Anti-Menin
Artikelnummer: A300-115A
Protein function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of...
| Schlagworte: | Anti-SCG2, Anti-MEN1, Anti-Menin |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-Menin (IHC)
Artikelnummer: IHC-00572
Protein function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of...
| Schlagworte: | Anti-SCG2, Anti-MEN1, Anti-Menin |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
MI-2
Artikelnummer: Cay29218-5
MI-2 is an inhibitor of the protein-protein interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 446 nM). It binds to menin (Kd = 158 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. MI-2...
| Schlagworte: | 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propyl-thieno[2,3-d]pyrimidine |
| Anwendung: | Menin-MLL fusion protein interaction inhibitor |
| CAS | 1271738-62-5 |
| MW: | 375.6 D |
ab 145,00 €
Anti-Menin
Artikelnummer: ARG10827.50
Protein function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of...
| Schlagworte: | Anti-SCG2, Anti-MEN1, Anti-Menin |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
559,00 €
Anti-Menin
Artikelnummer: A300-106A
Protein function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of...
| Schlagworte: | Anti-SCG2, Anti-MEN1, Anti-Menin |
| Anwendung: | WB, IP |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
ab 165,00 €
Human Secretogranin 2 / Chromogranin C ELISA Kit
Artikelnummer: G-HUFI02838.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-Menin
Artikelnummer: NSJ-R31676
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The MEN1 gene encodes Menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by...
| Schlagworte: | Anti-SCG2, Anti-MEN1, Anti-Menin, Menin Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
790,00 €