Zu "K14461" wurden 16 Artikel gefunden!
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Ezetimibe
Artikelnummer: Cay16331-25
Ezetimibe is an inhibitor of NPC1-like intracellular cholesterol transporter 1 (NPC1L1, Ki = 220 nM), a cholesterol transporter found in the apical membrane of enterocytes. It reduces cholesterol absorption in hamsters fed a high-cholesterol diet (ED50 = 0.04 mg/kg per day). Ezetimibe (346 nM) also reduces the...
| Schlagworte: | Ezetrol, SCH 58235, (3R,4S)-1,4-fluorophenyl-3-[(3S-3-4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Anwendung: | NPC1L1 inhibitor, intestinal cholesterol absorption inhibitor |
| CAS | 163222-33-1 |
| MW: | 409.4 D |
ab 98,00 €
Ezetimibe-d4
Artikelnummer: Cay25044-1
Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe (Cay-16331) by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of...
| Schlagworte: | Ezetrol-d4,... |
| Anwendung: | Internal standard, GC-MS, LC-MS |
| CAS | 1093659-89-2 |
| MW: | 413.5 D |
642,00 €
Ezetimibe
Artikelnummer: BPS-27749-2
Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes.
| Schlagworte: | ezetimibe, Zetia, (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one, |
| Anwendung: | Cholesterol absorption inhibitor, NPC1L1 inhibitor |
| MW: | 409.4 D |
ab 360,00 €
Anti-NPC1L1
Artikelnummer: G-CAB10049.100
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 352,00 €
3'-(2-Fluorophenyl) Ezetimibe
Artikelnummer: Cay34855-1
3'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor ezetimibe (Cay-16331).Formal Name: (3S,4R)-rel-1-(4-fluorophenyl)-3-[(3R)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. CAS Number: 1798008-25-9. Molecular Formula: C24H21F2NO3. Formula Weight: 409.4. Purity:...
| Schlagworte: | (3S,4R)-rel-1-(4-fluorophenyl)-3-[(3R)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Anwendung: | Ezetimibe isomer |
| CAS | 1798008-25-9 |
| MW: | 409.4 D |
ab 147,00 €
Anti-Niemann Pick C1 Like 1 / NPC1L1
Artikelnummer: NSJ-RQ6664
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract epithelial cells as well as in hepatocytes. The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a...
| Schlagworte: | Anti-NPC1L1, Anti-Niemann-Pick C1-like protein 1, Anti-NPC1-like intracellular cholesterol transporter 1, Niemann Pick C1... |
| Anwendung: | WB, IF, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
NPC1L1, Human NPC1 (Niemann-Pick disease, type C1,...
Artikelnummer: VHPS-6284
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | NPC1L1, Niemann-Pick C1-like protein 1 |
| Anwendung: | RNA quantification |
43,00 €
Npc1L1, Mouse NPC1-like 1, Real Time PCR Primer Set
Artikelnummer: VMPS-4302
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Schlagworte: | Npc1l1, Niemann-Pick C1-like protein 1 |
| Anwendung: | RNA quantification |
43,00 €
Anti-NPC1L1, NT (NPC1L1, Niemann-Pick C1-like protein 1)...
Artikelnummer: 039084-APC.200
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up...
| Schlagworte: | Anti-NPC1L1, Anti-Niemann-Pick C1-like protein 1 |
| Anwendung: | FLISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
993,00 €
Anti-NPC1L1, NT (NPC1L1, Niemann-Pick C1-like protein 1)...
Artikelnummer: 039084-Biotin.200
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up...
| Schlagworte: | Anti-NPC1L1, Anti-Niemann-Pick C1-like protein 1 |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
993,00 €
Anti-NPC1L1, NT (NPC1L1, Niemann-Pick C1-like protein 1)...
Artikelnummer: 039084-FITC.200
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up...
| Schlagworte: | Anti-NPC1L1, Anti-Niemann-Pick C1-like protein 1 |
| Anwendung: | FLISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
993,00 €
Anti-NPC1L1, NT (NPC1L1, Niemann-Pick C1-like protein 1)...
Artikelnummer: 039084-HRP.200
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up...
| Schlagworte: | Anti-NPC1L1, Anti-Niemann-Pick C1-like protein 1 |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
993,00 €