Zu "K13762" wurden 66 Artikel gefunden!
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PF-00489791
Artikelnummer: Cay40464-1
PF-00489791 is an inhibitor of phosphodiesterase 5A (PDE5A, IC50 = 1.9 nM). It does not cross the blood-brain barrier in rats. PF-00489791 (10 mg/kg) improves motor scores in a rat model of stroke induced by middle cerebral artery occlusion (MCAO).Formal Name:...
| Schlagworte: | PF-489791, UK 489791,... |
| Anwendung: | PDE5A inhibitor |
| CAS | 853003-48-2 |
| MW: | 476.6 D |
ab 39,00 €
Homosildenafil
Artikelnummer: Cay38891-1
Homosildenafil is an inhibitor of phosphodiesterase 5 (PDE5, IC50 = 8.9 nM). It has been found as an adulterant in dietary supplements for erectile dysfunction.Formal Name: 5-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one. CAS Number: 642928-07-2....
| Schlagworte: | Methylsidenafil,... |
| Anwendung: | PDE5 inhibitor |
| CAS | 642928-07-2 |
| MW: | 488.6 D |
ab 34,00 €
Human PDE5A (Phosphodiesterase 5A, cGMP Specific) ELISA Kit
Artikelnummer: ELK-ELK5022.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDE5A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDE5A. Next,...
| Schlagworte: | PDE5, CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase, cGMP-specific 3',5'-cyclic phosphodiesterase |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Tadalafil
Artikelnummer: Cay14024-10
Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5, IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 µM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 and...
| Schlagworte: | (6R)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12aR-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione |
| Anwendung: | Phosphodiesterase (PDE) V inhibitor |
| CAS | 171596-29-5 |
| MW: | 389.4 D |
ab 60,00 €
PDE5A1, active human recombinant protein
Artikelnummer: BPS-60050
Active human PDE5A1 (GenBank Accession No. NM_001083), full length, with N-terminal GST tag, MW=126 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PDE5, CGB-PDE, cGMP-specific 3',5'-cyclic phosphodiesterase, cGMP-binding cGMP-specific phosphodiesterase, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 126 kD |
708,00 €
PDE5A Assay Kit
Artikelnummer: BPS-60350
The PDE5A Assay Kit is designed for identification of inhibitors of PDE5A using fluorescence polarization. Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE5A, also known as cGMP-inhibited phosphodiesterase, has been implicated in cardiovascular function and...
| Schlagworte: | inhibitor screening, assay kit, PDE5, |
| Anwendung: | PDE5A inhibitor screening, FP |
672,00 €
Anti-cGMP, monoclonal
Artikelnummer: NB-26001-1
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. cGMP is a ubiquitous second messenger mediating cellular responses to various exogenous and endogenous signaling molecules. cGMP regulates physiological processes by activating protein kinases, gating specific ion...
| Schlagworte: | Anti-PDE5, Anti-PDE5A, Anti-CGB-PDE, EC=3.1.4.35, Anti-cGMP-binding cGMP-specific phosphodiesterase, Anti-cGMP-specific... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | broad |
507,00 €
Sildenafil citrate
Artikelnummer: CDX-S0078-M050
White to off-white powder. Soluble in DMSO (20mg/ml). Potent cGMP-specific phosphodiesterase inhibitor that is highly selective for PDE5. It inhibits PDE5 activity in isolated rabbit platelets with an IC50 value of 3.6nM (3nM in human corpus cavernosum) compared to inhibition of PDE1 and PDE3 activities (IC50s =...
| Schlagworte: | 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt,... |
| Anwendung: | PDE5 inhibitor |
| CAS | 171599-83-0 |
| MW: | 666,7 D |
ab 153,00 €
Sildenafil
Artikelnummer: Cay10008671-10
Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively. It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 µM, respectively). Sildenafil reverses glucose-induced decreases...
| Schlagworte: | 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one |
| Anwendung: | PDE5 inhibitor |
| CAS | 139755-83-2 |
| MW: | 474.6 D |
ab 64,00 €
Dipyridamole
Artikelnummer: Cay18189-5
Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50 = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells. It also scavenges the free radicals that inactivate cyclooxygenase, leading to the inhibition of platelet activation and...
| Schlagworte: | NSC 515776, NSC 619103, 2,2',2",2"'-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-ethanol |
| Anwendung: | PDE5A inhibitor |
| CAS | 58-32-2 |
| MW: | 504.6 D |
ab 50,00 €
PDE5A1 Assay Kit
Artikelnummer: BPS-60351
The PDE5A1 Assay Kit is designed for identification of PDE5A1 inhibitors sing fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE5A to the binding agent. PDE5A catalyzes the hydrolysis of the phosphodiester bond in dye-labeled cyclic guanosine...
| Schlagworte: | PDE5A, phosphodiesterase 5A, |
| Anwendung: | Enzyme kinetics, inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.173,00 €
MY-5445
Artikelnummer: Cay20872-10
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 µM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 µM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 µM.Formal Name:...
| Schlagworte: | N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine |
| Anwendung: | PDE5 inhibitor |
| CAS | 78351-75-4 |
| MW: | 331.8 D |
ab 43,00 €