Zu "K13761" wurden 44 Artikel gefunden!
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(S)-BAY 73-6691
Artikelnummer: Cay44764-10
(S)-BAY 73-6691 is an inhibitor of phosphodiesterase 9A (PDE9A. IC50 = 88 nM) and the (S)-enantiomer of BAY 73-6691. Formal Name: 1-(2-chlorophenyl)-1,5-dihydro-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-4H-pyrazolo[3,4-d]pyrimidin-4-one. CAS Number: 794568-91-5. Molecular Formula: C15H12ClF3N4O. Formula Weight: 356.7....
| Schlagworte: | 1-(2-chlorophenyl)-1,5-dihydro-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| Anwendung: | PDE9A inhibitor |
| CAS | 794568-91-5 |
| MW: | 356.73 D |
ab 71,00 €
PF-04447943
Artikelnummer: Cay24299-25
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. It is over 1,000-fold more selective for PDE9A over 79 non-PDE targets, with the exception of the melatonin MT3/ML2...
| Schlagworte: | 1,5-dihydro-6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyr... |
| Anwendung: | PDE9A inhibitor |
| CAS | 1082744-20-4 |
| MW: | 395.5 D |
ab 54,00 €
Anti-PDE9A
Artikelnummer: ARG10812.50
Protein function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755,...
| Schlagworte: | Anti-High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
| Anwendung: | IF, ELISA, ICC, IF, IHC, IP, WB, DB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
608,00 €
PDE9A2, active human recombinant protein
Artikelnummer: BPS-60090
Active human PDE9A2 (GenBank Accession No. NM_001001567), full length with Nterminal GST tag, MW=87.7 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 87.7 kD |
685,00 €
PDE9A Assay Kit
Artikelnummer: BPS-60381
Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE9A is primarily expressed in spleen, small intestine, and brain. PDE9 inhibitors have been studied as therapeutics for treatment of cardiovascular diseases, diabetes, and neurodegenerative disorders. The PDE9A Assay...
| Schlagworte: | inhibitor screening, assay kit, PDE9A, |
| Anwendung: | Enzyme kinetics, inhibitor screening, HTS |
| Spezies-Reaktivität: | human |
767,00 €
BI-409306
Artikelnummer: Cay30375-1
BI-409306 is a potent and selective phosphodiesterase 9A (PDE9A) inhibitor with IC50 values of 65 and 168 nM for the human and rat enzymes, respectively. It is selective for PDE9A over PDE2A, -3A, -4B, -5A, -6AB, -7A and -10A and 95 non-PDE targets at 10 µM but does inhibit human PDE1A and PDE1C (IC50s = 1.45 and...
| Schlagworte: | 1,5-dihydro-6-(2-pyridinylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| Anwendung: | Potent, selective PDE9A inhibitor |
| CAS | 1189767-28-9 |
| MW: | 311.3 D |
ab 93,00 €
PDE9A2 (human, recombinant)
Artikelnummer: Cay32039-100
Phosphodiesterase 9A (PDE9A) is a high-affinity cGMP-specific cyclic nucleotide phosphodiesterase. Alternative splicing in the 5' region of PDE9A mRNA results in a variety of PDE9A isoforms, including PDE9A2, whereas the 3' region encoding the catalytic PDE domain does not vary between isoforms. PDE9A2 mRNA is...
| Schlagworte: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 89.5 kD |
569,00 €
PF-04449613
Artikelnummer: Cay30946-1
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50 = 22 nM). It is selective for PDE9A over PDE1C (IC50 = >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 µM but does inhibit the human...
| Schlagworte: | 1,5-dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| Anwendung: | PDE9A inhibitor |
| CAS | 1236858-52-8 |
| MW: | 395.5 D |
ab 73,00 €
Anti-PDE9A
Artikelnummer: ATA-HPA011380.100
Protein function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755,...
| Schlagworte: | Anti-High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
High affinity cGMP-specific 3',5'-cyclic...
Artikelnummer: CSB-EP527985HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-593aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MGSGSSSYRP KAIYLDIDGR IQKVIFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM VSIDPTMPAN SERTPYKVRP VAIKQLSAGV EDKRTTSRGQ SAERPLRDRR...
| Schlagworte: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, Recombinant Human High affinity cGMP-specific 3',5'-cyclic... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 76.0 kD |
ab 247,00 €
High affinity cGMP-specific 3,5-cyclic phosphodiesterase...
Artikelnummer: CSB-EP530347MO.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1-534aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MGAGSSSYRP KAIYLDIDGR IQKVVFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM VSIDPTMPAN SERTPYKVRP VAVKQVSERE ELIQGVLAQV AEQFSRAFKI NELKAEVANH LAVLEKRVEL...
| Schlagworte: | Pde8b, Pde9a, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, Recombinant Mouse High affinity cGMP-specific... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | mouse |
| MW: | 65.7 kD |
ab 364,00 €
PDE-9 inhibitor
Artikelnummer: TGM-T12389-100mg
Description: PDE-9 inhibitor is used for treatment neurodegenerative diseases. Target: Others. Smiles: C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
| Anwendung: | PDE9 inhibitor |
| CAS | 1082743-70-1 |
| MW: | 393.48 D |
ab 133,00 €