Zu "K13298" wurden 28 Artikel gefunden!
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IBMX
Artikelnummer: Cay13347-100
IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 µM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP...
| Schlagworte: | 1-Methyl-3-Isobutylxanthine, Isobutylmethylxanthine, NSC 165960, SC-2964,... |
| Anwendung: | PDE inhibitor |
| CAS | 28822-58-4 |
| MW: | 222.3 D |
ab 50,00 €
IBMX
Artikelnummer: AG-CR1-3512-M500
Cell permeable protein kinase C (PKC) inhibitor. Inhibits also protein kinase A (PKA).
| Schlagworte: | 3-Isobutyl 1-methylxanthine, NSC 165960, EINECS 249-259-3 |
| Anwendung: | Phosphodiesterase inhibitor |
| CAS | 28822-58-4 |
| MW: | 222,3 D |
ab 121,00 €
PDE11A4, active human recombinant protein
Artikelnummer: BPS-60110
Active human PDE11A4 (GenBank Accession No. BAB62712), full length with N-terminal GST tag, MW= 131 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | cAMP and cGMP phosphodiesterase 11A, Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 131 kD |
672,00 €
Quercetin-d3 (hydrate)
Artikelnummer: Cay26418-1
Quercetin-d3(hydrate) is intended for use as an internal standard for the quantification of quercetin (Cay-10005169) by GC- or LC-MS. Quercetin is an abundant flavonoid that has been isolated from a variety of plants and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory...
| Schlagworte: | 2-(4,5-dihydroxyphenyl-2,3,6-d3)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, hydrate |
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, phosphodiesterase inhibitor |
| MW: | 305.3 D |
ab 115,00 €
Anti-PDE11A
Artikelnummer: ARG10787.50
Protein function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. [The UniProt Consortium]
| Schlagworte: | Anti-PDE11A, EC=3.1.4.35, EC=3.1.4.53, Anti-cAMP and cGMP phosphodiesterase 11A, Anti-Dual 3',5'-cyclic-AMP and -GMP... |
| Anwendung: | IF, ELISA, ICC, IF, IHC (paraffin), IP, WB, DB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
576,00 €
Anti-PDE11A
Artikelnummer: ARG10788.50
Protein function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. [The UniProt Consortium]
| Schlagworte: | Anti-PDE11A, EC=3.1.4.35, EC=3.1.4.53, Anti-cAMP and cGMP phosphodiesterase 11A, Anti-Dual 3',5'-cyclic-AMP and -GMP... |
| Anwendung: | IF, ELISA, ICC, IF, IHC, IP, WB, DB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
576,00 €
Anti-phospho-PDE11A (Ser117 / Ser124)
Artikelnummer: ARG10817.50
Protein function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. [The UniProt Consortium]
| Schlagworte: | Anti-phospho-PDE11A, EC=3.1.4.35, EC=3.1.4.53, Anti-phospho-cAMP and cGMP phosphodiesterase 11A, Anti-phospho-Dual... |
| Anwendung: | ELISA, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
592,00 €
Anti-phospho-PDE11A (Ser117)
Artikelnummer: ARG10818.50
Protein function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. [The UniProt Consortium]
| Schlagworte: | Anti-phospho-PDE11A, EC=3.1.4.35, EC=3.1.4.53, Anti-phospho-cAMP and cGMP phosphodiesterase 11A, Anti-phospho-Dual... |
| Anwendung: | IF, ELISA, ICC, IF, IHC, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
592,00 €
Anti-PDE11A, Internal
Artikelnummer: ARG64245.100
Protein function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. [The UniProt Consortium]
| Schlagworte: | Anti-PDE11A, EC=3.1.4.17, EC=3.1.4.35, Anti-cAMP and cGMP phosphodiesterase 11A, Anti-Dual 3',5'-cyclic-AMP and -GMP... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
784,00 €
IBMX
Artikelnummer: BPS-27213
IBMX, also known as 1-Methyl-3-Isobutylxanthine and Isobutylmethylxanthine, is a widely-used inhibitor of cAMP and cGMP PDEs. It has been shown that the increase in cellular cAMP and cGMP levels, resulting from the inhibition of PDEs by IBMX, activates cyclicnucleotide-regulated protein kinases. IBMX does not...
| Anwendung: | PDE inhibitor |
| MW: | 222.3 D |
244,00 €
Quercetin
Artikelnummer: BPS-27214
Quercetin is an inhibitor of PDEs of both cAMP and cGMP. It is a flavonoid found in plant and fruit bark or rinds. It is estimated that normal dietary intake of Quercetin for humans is 0.1-0.2 mg/kg. Quercetin can induce renal adenomas in male rats when fed at 2,000 mg/kg.
| Anwendung: | PDE inhibitor |
| MW: | 302.2 D |
297,00 €
Aminophylline
Artikelnummer: BPS-27731
Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.
| Schlagworte: | theophylline ethylenediamine, bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione), ethane-1,2-diamine, |
| Anwendung: | PDE inhibitor |
| MW: | 420.4 D |
423,00 €