Zu "K13129" wurden 71 Artikel gefunden!
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NEU
SMN1 Protein, Mouse, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-02920-10ug
Description: SMN1 Protein, Mouse, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 35.3 kDa and the accession number is P97801.
| Schlagworte: | Smn1 , Survival motor neuron protein , Smn |
| MW: | 35.3 kD |
ab 157,00 €
Risdiplam
Artikelnummer: Cay29028-5
Risdiplam is a survival of motor neuron-2 (SMN2) splicing modifier. It enhances SMN2 splicing (EC1.5x = 40 nM) and increases SMN protein levels (EC1.5x = 163 nM) in cellular assays. Risdiplam (3 mg/kg) increases brain and quadricep muscle SMN protein levels in the adult C/C-allele mouse model of mild spinal muscular...
| Schlagworte: | RG-7916, RO7034067,... |
| Anwendung: | SMN2 splicing modifier |
| CAS | 1825352-65-5 |
| MW: | 401.5 D |
ab 58,00 €
Anti-SMN1
Artikelnummer: A301-863A
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2,...
| Schlagworte: | Anti-SMN, Anti-SMN1, Anti-SMN2, Anti-SMNC, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
LMI070
Artikelnummer: Cay26757-1
LMI070 is an SMN2 splice modulator. It selectively enhances SMN2 splicing by stabilizing the complex formed by the U1 small nuclear ribonucleic protein (snRNP) and SMN2 pre-mRNA. LMI070 (3-30 mg/kg) increases the expression of the full-length SMN2 trancript and, at doses ranging from 0.3 to 30 mg/kg, increases SMN...
| Schlagworte: | Branaplam, NVS-SM1, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-phenol |
| Anwendung: | SMN2 splice modulator |
| CAS | 1562338-42-4 |
| MW: | 393.5 D |
ab 69,00 €
Branaplam
Artikelnummer: TGM-T4641-2mg
Description: Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. Target: Potassium Channel, Others, DNA/RNA Synthesis. Smiles: CC1(C)CC(CC(C)(C)N1)Oc1ccc(nn1)-c1ccc(cc1O)-c1cn[nH]c1. References: Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA...
| Schlagworte: | LMI 070, NVS-SM1 |
| Anwendung: | Targets survival motor neuron protein (SMN) |
| CAS | 1562338-42-4 |
| MW: | 393.48 D |
ab 40,00 €
Anti-Survival Motor Neuron Protein (human), clone 7B10
Artikelnummer: AG-20T-0003-C200
Monoclonal Antibody. Recognizes a sequence of up to 9 amino acids in the N-terminal domain of human SMN. Isotype: Mouse IgG1. Clone: 7B10. Applications: IP, WB. Liquid. In PBS. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the...
| Schlagworte: | Anti-SMN, Anti-SMN1, Anti-SMNC, Anti-SMN2, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
| Anwendung: | IP, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
385,00 €
Anti-SMN1 / SMN2, Internal
Artikelnummer: ARG64148.100
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2,...
| Schlagworte: | Anti-SMN, Anti-SMN2, Anti-SMNC, Anti-SMN1, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
Anti-SMN1
Artikelnummer: A301-862A
Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2,...
| Schlagworte: | Anti-SMN, Anti-SMN1, Anti-SMN2, Anti-SMNC, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
SMN tudor domain (human recombinant)
Artikelnummer: Cay14136-100
Tudor domains are small protein structural motifs of ~50 amino acids related to the "Royal family" of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism,...
| Schlagworte: | SMN, SMN1, SMN2, SMNC, Gemin-1, Gemin-1, Component of gems 1, Component of gems 1, Survival motor neuron protein, Survival... |
| Anwendung: | Binding assays |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 42,6 kD |
531,00 €
Mouse SMN1 / Survival of Motor Neuron 1, Telomeric ELISA Kit
Artikelnummer: G-MOFI01117.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
Anti-SMN1/2 / Survival of Motor Neuron 1/2
Artikelnummer: NSJ-R32249
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The Survival of Motor Neuron gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of...
| Schlagworte: | Anti-SMN, Anti-SMNC, Anti-SMN1, Anti-SMN2, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-SMN
Artikelnummer: NSJ-R33427-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Survival of motor neuron, SMN1, SMN2 Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome....
| Schlagworte: | Anti-SMN, Anti-SMN1, Anti-SMNC, Anti-SMN2, Anti-Gemin-1, Anti-Component of gems 1, Anti-Survival motor neuron protein, SMN... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €