Zu "K13050" wurden 190 Artikel gefunden!
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Alirocumab Biosimilar (Human Proprotein Convertase...
Artikelnummer: BPS-83968-1
Alirocumab, also known as REGN 727, is a recombinant monoclonal antibody that targets PCSK9 (proprotein convertase subtilisin/kexin type 9). It increases the ability of the liver to bind LDL-cholesterol (LDL-C) and reduces levels of LDL-C in blood. Alirocumab improves atherosclerosis and inflammation and is used in...
| Schlagworte: | PCSK9, Proprotein convertase subtilisin/kexin type 9, Neural apoptosis-regulated convertase 1, Proprotein convertase 9,... |
| Anwendung: | ELISA, FC, FA |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
| CAS | 1245916-14-6 |
ab 827,00 €
Mouse PCSK9 ELISA Kit
Artikelnummer: ARG81823.96
Protein function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and...
| Schlagworte: | PC9, Pcsk9, Narc1, NARC-1, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
1.118,00 €
PF-06446846 (hydrochloride)
Artikelnummer: Cay20914-10
PF-06446846 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) translation. It inhibits translation of mRNA encoding PCSK9 by isolated human ribosomes when used at a concentration of 100 µM. PF-06446846 also inhibits PCSK9 secretion by Huh7 cells (IC50 = 0. µM). In vivo, PF-06446846 (50 mg/kg)...
| Schlagworte: | N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)-benzamide, hydrochloride |
| Anwendung: | PCSK9 translation inhibitor |
| CAS | 1632250-50-0 |
| MW: | 433.9 D |
ab 186,00 €
PCSK9, His, Human
Artikelnummer: GSC-Z05733-100
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations...
| Schlagworte: | PCSK9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, Proprotein... |
| Ursprungsart: | human |
| MW: | 14-68 kD |
ab 524,00 €
PCSK9, His, Mouse
Artikelnummer: GSC-Z06298-100
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations...
| Schlagworte: | Pcsk9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, Proprotein... |
| Ursprungsart: | mouse |
| MW: | 59/14 kD |
ab 457,00 €
Pcsk9 Protein (His Tag) (mouse), recombinant
Artikelnummer: E-PDMM100245.1
roprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene...
| Schlagworte: | PC9, Pcsk9, Narc1, NARC-1, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural... |
| Ursprungsart: | mouse |
ab 192,00 €
Anti-PCSK9 (neutralizing antibody)
Artikelnummer: BPS-71207
Neutralizing recombinant human antibody (IgG1) recognizing the LDLR binding region of human PCSK9. Useful as a control inhibitor of PCSK9-LDLR binding using the PCSK9 (biotinylated)-LDLR-Binding Assay Kit, Cat. # BPS-72002.
| Schlagworte: | Anti-PCSK9, |
| Anwendung: | PCSK9 assays |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
834,00 €
Anti-PCSK9 (human)
Artikelnummer: Cay10007185-1
Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism. Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia which is characterized by an increase in low density lipoprotein (LDL)...
| Schlagworte: | Anti-PC9, Anti-PC9, Anti-PCSK9, Anti-NARC1, Anti-NARC-1, Anti-NARC-1, Anti-PSEC0052, Anti-Proprotein convertase 9,... |
| Anwendung: | IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
468,00 €
PCSK9 Protein (His Tag) (recombinant human)
Artikelnummer: E-PKSH032944.50
Protein Construction: Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln152&Ser153-Gln692 is expressed with a 6His tag at the C-terminus. Sequence: Gln31-Gln152&Ser153-Gln692. Fusion tag: C-6His Endotoxin: < 1.0 EU per...
| Schlagworte: | PC9, PCSK9, NARC1, NARC-1, PSEC0052, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural... |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 14 kD |
ab 107,00 €
PCSK9 (human, recombinant)
Artikelnummer: Cay20631-50
Proprotein convertase subtilisin kexin 9 (PCSK9) is a zymogen and member of the subtilisin serine protease family that reduces protein levels of LDL receptors (LDLRs), the receptor for LDL-cholesterol (LDL-C). It is primarily expressed in the liver and is composed of an N-terminal prodomain that regulates PCSK9...
| Schlagworte: | PC9, PC9, PCSK9, NARC1, NARC-1, NARC-1, PSEC0052, Proprotein convertase 9, Proprotein convertase 9, Subtilisin/kexin-like... |
| Anwendung: | ELISA, FC, WB |
| Exprimiert in: | Human cells |
| MW: | 71 kD |
588,00 €
PCSK9, C-terminal His-Avi, Biotin-labeled
Artikelnummer: BPS-71304-1
Human proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as FH3, HCHOLA3, and PC9, GenBank Accession No. NM_174936, a.a. 31-692(end), with C-terminal His and Avi tags, MW=73.8 kDa (calculated), expressed in an HEK293 cell expression system and enzymatically biotinylated using Avitag(TM) technology.
| Schlagworte: | PC9, PCSK9, NARC1, NARC-1, PSEC0052, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural... |
| Anwendung: | Protein binding studies, small molecule screening, drug discovery |
| Exprimiert in: | human cells |
| Ursprungsart: | human |
| MW: | 73,8 kD |
ab 506,00 €
PCSK9, C-terminal Avi-His, Biotin-labeled
Artikelnummer: BPS-71305
Human proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as FH3, HCHOLA3, and PC9, GenBank Accession No. NM_174936, a.a. 31-692(end), with C-terminal His and Avi tags, MW=73.8 kDa (calculated), expressed in an HEK293 cell expression system and enzymatically biotinylated using AvitagT technology.
| Schlagworte: | PC9, PCSK9, NARC1, NARC-1, PSEC0052, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural... |
| Anwendung: | Binding studies, small molecule screening, drug discovery |
| Exprimiert in: | human cells |
| Ursprungsart: | human |
| MW: | 73.8 kD |
685,00 €