Zu "K12800" wurden 126 Artikel gefunden!
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Anti-NLRP3/NALP3, clone Cryo-2
Artikelnummer: AG-20B-0014-C100
Recognizes mouse and human NLRP3/NALP3. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the...
| Schlagworte: | NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein |
| Anwendung: | IHC, IP, WB, ICC, ChIP |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human , mouse |
385,00 €
NEU
Emlenoflast
Artikelnummer: Cay45477-10
An NLRP3 inflammasome inhibitor. SMILES: O=C(NS(=O)(C1=NN(C(C)C)C=C1)=O)NC2=C3CCCC3=CC4=C2CCC4. InChi Code: InChI=1S/C19H24N4O3S/c1-12(2)23-10-9-17(21-23)27(25,26)22-19(24)20-18-15-7-3-5-13(15)11-14-6-4-8-16(14)18/h9-12H,3-8H2,1-2H3,(H2,20,22,24). InChi Key: MTOUOUSKXWSTAX-UHFFFAOYSA-N
| Schlagworte: | Inzomelid, IZD-174, MCC7840,... |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 1995067-59-8 |
| MW: | 388.49 D |
ab 480,00 €
NEU
Usnoflast
Artikelnummer: Cay45301-1
An NLRP3 inflammasome inhibitor, inhibits ASC oligomerization in LPS-primed and ATP-activated THP-1 cells, reduces nigericin-induced IL-1beta release in LPS-primed THP-1 cells and microglia (IC50s = 11 and 43 nM, respectively), reduces ATP-induced IL-1beta release in LPS-primed human PBMCs (IC50 = 4.5 nM), improves...
| Schlagworte: | ZYIL1, 2-[(2R)-1E,2-dimethyl-2-pyrrolidinyl]-N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-ethenesulfonamide |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 2455519-86-3 |
| MW: | 403.54 D |
ab 624,00 €
NLRP3 Protein, Human, Recombinant (aa 131-704, His)
Artikelnummer: TGM-TMPH-04597-100ug
Description: NLRP3 Protein, Human, Recombinant (aa 131-704, His) is expressed in E. coli. The accession number is Q96P20.
| Schlagworte: | Angiotensin/vasopressin receptor AII/AVP-like , PYRIN-containing APAF1-like protein 1 , C1orf7 , PYPAF1 , NACHT, LRR and... |
| MW: | 73.9 kD |
ab 109,00 €
Anti-Recombinant NLRP3, clone 10A4
Artikelnummer: E-AN301382L.100
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome...
| Schlagworte: | Anti-NLRP3, Anti-Cryopyrin, Anti-Caterpiller protein 1.1, Anti-PYRIN-containing APAF1-like protein 1,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
391,00 €
Human NALP3 / Cryopyrin ELISA Kit
Artikelnummer: ARG82259.96
Protein function: As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5)....
| Schlagworte: | NLRP3, CLR1.1, C1orf7, Cryopyrin, Caterpiller protein 1.1, PYRIN-containing APAF1-like protein 1, Angiotensin/vasopressin... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.463,00 €
MCC950 . Na
Artikelnummer: AG-CR1-3615-M001
Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml). Chemical. CAS: 256373-96-3. Formula: C20H23N2NaO5S. MW: 426.5. Synthetic. Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and...
| Schlagworte: | MCC950, CP-456,773, CRID3, 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 256373-96-3 |
| MW: | 426,5 D |
ab 39,00 €
MCC950
Artikelnummer: Cay17510-1
MCC950 is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation. It inhibits ATP-induced IL-1beta release in LPS-primed mouse bone marrow-derived macrophages (BMDMs, IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1beta release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM, indicating...
| Schlagworte: | CP 456,773, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide |
| Anwendung: | NLRP3 inhibitor |
| CAS | 210826-40-7 |
| MW: | 404.5 D |
ab 126,00 €
NALP3 (delPYD), FLAG-Tag
Artikelnummer: BPS-100454
Human NLR Family Pyrin Domain Containing 3 (NLRP3), also known as NALP3, Cold Autoinflammatory Syndrome 1 Protein (CIAS1), cryopyrin and PYPAF1, Genbank Accession No. NM_004895, a.a. 134-1036(end) with N-terminal FLAG-tag, expressed in a HEK293 expression system. MW = 105 kDa.
| Schlagworte: | CLR1.1, Cryopyrin, Caterpiller protein 1.1, PYRIN-containing APAF1-like protein 1, Angiotensin/vasopressin receptor... |
| Anwendung: | Immunotherapy studies |
| Exprimiert in: | human cells |
| Ursprungsart: | human |
| MW: | 120 kD |
760,00 €
Anti-NLRP3/NALP3 (mouse), clone Cryo-1
Artikelnummer: AG-20B-0006-C100
Recognizes mouse NLRP3/NALP3. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like...
| Schlagworte: | NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | mouse |
462,00 €
Monosodium urate (crystals)
Artikelnummer: AG-CR1-3950-2002
NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity. Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1beta and IL-18.
| Schlagworte: | MSU (crystals), Uric acid (crystals) |
| Anwendung: | NLRP3/NALP3 inflammasome activator |
| Wirt: | Synthetic |
| CAS | 1198-77-2 |
| MW: | 167,1 D |
ab 94,00 €
NALP3 (CIAS1) Human Recombinant Protein
Artikelnummer: BPS-80117
Human NLR Family Pyrin Domain Containing 3 (NLRP3), also known as NALP3, Cold Autoinflammatory Syndrome 1 Protein (CIAS1), cryopyrin and PYPAF1 (Genbank Accession No. NM_004895), a.a. 2-1036(end) with N-terminal His-FLAG-tag, expressed in a baculovirus infected Sf9 cell expression system. MW = 120 kDa (calculated)....
| Schlagworte: | CLR1.1, Cryopyrin, Caterpiller protein 1.1, PYRIN-containing APAF1-like protein 1, Angiotensin/vasopressin receptor... |
| Anwendung: | Protein function studies, inhibitor screening |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 120 kD |
834,00 €