Zu "K12407" wurden 68 Artikel gefunden!
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D-Glucose-6-phosphate (sodium salt)
Artikelnummer: Cay20376-500
D-Glucose-6-phosphate is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or by the conversion of glucose-1-phosphate by phosphoglucomutase, which is the first step of glycogen synthesis. It is stored as glycogen when blood glucose levels are high. Disruption of D-glucose-6-phosphate...
| Schlagworte: | G6P, Sodium Glucose-6-Phosphate, D-glucose-6-(dihydrogen phosphate), monosodium salt |
| Anwendung: | Glycolysis / pentose phosphate pathway / glycogen synthesis starting molecule |
| CAS | 54010-71-8 |
| MW: | 282.1 D |
ab 49,00 €
Sinogliatin
Artikelnummer: Cay43205-1
Sinogliatin is an activator of glucokinase. It increases the hepatic levels of glucokinase and pancreatic levels of insulin in a rat model of diabetes induced by streptozotocin (Cay-13104) and a high-fat diet (HFD) when administered at doses of 10 or 30 mg/kg per day. Sinogliatin (10 or 30 mg/kg) decreases blood...
| Schlagworte: | HMS5552,... |
| Anwendung: | Glucokinase activator |
| CAS | 1191996-10-7 |
| MW: | 462.93 D |
ab 83,00 €
AM2394
Artikelnummer: Cay20992-10
AM2394 is an activator of glucokinase with an EC50 value of 60 nM in an enzyme assay in the presence of glucose. Oral administration of AM2394 (3-30 mg/kg) decreases plasma glucose levels in an oral glucose tolerance test in an ob/ob mouse model of diabetes.Formal Name:...
| Schlagworte: | N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-urea |
| Anwendung: | Glucokinase agonist |
| CAS | 1442684-77-6 |
| MW: | 423.5 D |
ab 56,00 €
LY2608204
Artikelnummer: Cay22914-1
LY2608204 is an activator of glucokinase (GK, EC50 = 42 nM). It stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 = 579 nM). LY2608204 (30 mg/kg) decreases plasma glucose levels in a dose-dependent manner in fasted rats.Formal Name:...
| Schlagworte: | (1R,2S)-2-cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]-cyclopropanecarbo... |
| Anwendung: | Glucokinase activator |
| CAS | 1234703-40-2 |
| MW: | 559.8 D |
ab 65,00 €
MK-0941
Artikelnummer: Cay25642-1
MK-0941 is a glucokinase activator with EC50 values of 0.24 and 0.065 µM at low (2.5 mM) and high (10 mM) concentrations of glucose, respectively. It increases insulin secretion from isolated rat islets of Langerhans and glucose uptake by hepatocytes in vitro. MK-0941 reduces blood glucose levels in high-fat...
| Schlagworte: | 3-[[6-(ethylsulfonyl)-3-pyridinyl]oxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-benzamide,... |
| Anwendung: | Glucokinase activator |
| CAS | 1137916-97-2 |
| MW: | 556.6 D |
ab 56,00 €
Human GCK / Glucokinase ELISA Kit
Artikelnummer: G-HUFI00759.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Mouse GCK / Glucokinase ELISA Kit
Artikelnummer: G-MOFI00271.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
Anti-GCK
Artikelnummer: E-AB-15062.120
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane...
| Schlagworte: | Anti-GCK, Anti-HK4, Anti-HK IV, Anti-Glucokinase, Anti-Hexokinase-4, Anti-Hexokinase-D, Anti-Hexokinase type IV, GCK... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
D-Mannoheptulose
Artikelnummer: Cay16548-10
D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and...
| Schlagworte: | NSC 226836, D-manno-2-heptulose |
| Anwendung: | Glucokinase / hexokinase inhibitor |
| CAS | 3615-44-9 |
| MW: | 210.2 D |
ab 73,00 €
D-Mannoheptulose
Artikelnummer: AG-CR1-3695-M025
Naturally occurring heptose in avocado fruit. Hexokinase (HK) and glucokinase inhibitor in diverse organisms by competing with D-glucose. Useful agent for immunometabolism research. Blocks glucose phosphorylation by blocking hexokinase. Prevents the conversion of glucose to glucose-6-phosphate that can mediate the...
| Schlagworte: | D-Manno-2-heptulose, NSC 226836 |
| Anwendung: | Hexokinase (HK) / glucokinase inhibitor |
| CAS | 3615-44-9 |
| MW: | 210.2 D |
ab 66,00 €
Anti-GCK / Glucokinase (N-Terminal Region)
Artikelnummer: NSJ-F54202-0.05ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in...
| Schlagworte: | Anti-HK4, Anti-HK IV, Anti-Glucokinase, Anti-Hexokinase-D, Anti-Hexokinase-4, Anti-Hexokinase type IV, GCK Antibody /... |
| Anwendung: | WB, IHC (paraffin), IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 361,00 €
PF-04937319 (hydrate)
Artikelnummer: Cay30926-1
PF-04937319 is an activator of glucokinase (EC50s = 174, 407, and 269 nM for the recombinant human, rat, and dog enzymes, respectively). It increases glucose-induced insulin secretion in isolated rat islets when used at concentrations of 4 and 12 µM. PF-04937319 (3-100 mg/kg) reduces postprandial plasma glucose...
| Schlagworte: | N,N-dimethyl-5-[[2-methyl6-[[5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide, hydrate |
| Anwendung: | Glucokinase activator |
| MW: | 432.4 D |
ab 56,00 €