Zu "K12320" wurden 78 Artikel gefunden!
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A71915 (trifluoroacetate salt)
Artikelnummer: Cay43005-1
A GC-A antagonist (Ki = 0.66 nM), inhibits cGMP production induced by ANP in NB-OK-1 cells (pA2 = 9.48), induces dilation and increases glomerular blood flow in rat hydronephrotic renal vascular segments but inhibits ANP-induced dilation in the same preparations at 1 µM, prevents BNP-induced increases in spontaneous...
| Schlagworte: | [Arg6,Cha8]ANP-(6-15)-D-Tic-Arg-Cys-NH2, [Arg6,Cha8]Atrial Natriuretic Peptide-(6-15)-D-Tic-Arg-Cys-NH2,... |
| Anwendung: | Guanylyl cyclase A receptor antagonist |
| MW: | 1613.97 D |
ab 147,00 €
Linaclotide
Artikelnummer: Cay24085-1
Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa). Luminal exposure to 5 µg of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C...
| Schlagworte: | L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-t... |
| Anwendung: | Guanylate cyclase C receptor / enterotoxin receptor agonist |
| CAS | 851199-59-2 |
| MW: | 1526.7 D |
ab 49,00 €
Plecanatide (acetate)
Artikelnummer: Cay33878-1
Plecanatide is a peptide agonist of the guanylate cyclase C receptor. It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67, a marker of cell proliferation, induced by dextran...
| Schlagworte: | SP-304,... |
| Anwendung: | GUCY2C peptide agonist |
| CAS | 1075732-84-1 |
| MW: | 1741.9 D |
ab 93,00 €
Anti-Guanylyl cyclase C
Artikelnummer: ARG10785.50
Protein function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin. [The UniProt Consortium]
| Schlagworte: | Anti-GC-C, Anti-Guc2c, Anti-Gucy2c, EC=4.6.1.2, Anti-STA receptor, Anti-Guanylyl cyclase C, Anti-Intestinal guanylate... |
| Anwendung: | IF, Dot Blot, ELISA, ICC, IF, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
608,00 €
Human GUCY2C / Heat-stable enterotoxin receptor ELISA Kit
Artikelnummer: G-HUFI01379.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Linaclotide-d4
Artikelnummer: Cay28798-500
Linaclotide-d4 is intended for use as an internal standard for the quantification of linaclotide (Cay-24085) by GC- or LC-MS. Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa). Luminal exposure to 5 µg of linaclotide...
| Schlagworte: | ((3S,6R,15R,20R,23S,26R,29R,32R,37R,40S,45aS)-32-amino-40-(2-amino-2-oxoethyl)-26-(2-carboxyethyl)-23-(4-hydroxybenzyl)-9-... |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, intestinal guanylate cyclase agonist |
| MW: | 1530.8 D |
991,00 €
Guanylin (human) (trifluoroacetate salt)
Artikelnummer: Cay33140-1
Guanylin is a peptide hormone activator of membrane-bound guanylate cyclase C (GC-C). It contains four cysteines that can form disulfide bridges leading to two possible isoforms, with the active form containing disulfide bridges between Cys4 and Cys12 and Cys7 and Cys15. Guanylin is found in epithelial cells of the...
| Schlagworte: | L-prolylglycyl-L-threonyl-L-cysteinyl-L-alpha-glutamyl-L-isoleucyl-L-cysteinyl-L-alanyl-L-tyrosyl-L-alanyl-L-alanyl-L-cyst... |
| Anwendung: | GUCY2C peptide hormone activator |
| MW: | 1458.7 D |
ab 359,00 €
Anti-GUCY2C
Artikelnummer: ATA-HPA037655.100
Protein function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium...
| Schlagworte: | Anti-GC-C, Anti-GUC2C, Anti-hSTAR, Anti-GUCY2C, EC=4.6.1.2, Anti-STA receptor, Anti-Guanylyl cyclase C, Anti-Intestinal... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Heat-stable enterotoxin receptor (GUCY2C), partial,...
Artikelnummer: CSB-BP010053HU.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 24-430aa. Protein Length: Extracellular Domain. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: SQVSQNCHNG SYEISVLMMG NSAFAEPLKN LEDAVNEGLE IVRGRLQNAG LNVTVNATFM YSDGLIHNSG DCRSSTCEGL DLLRKISNAQ RMGCVLIGPS CTYSTFQMYL DTELSYPMIS...
| Schlagworte: | GC-C, hSTAR, GUC2C, GUCY2C, EC=4.6.1.2, STA receptor, Guanylyl cyclase C, Intestinal guanylate cyclase, Heat-stable... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 48.5 kD |
ab 489,00 €
Heat-stable enterotoxin receptor (Gucy2c), partial, rat,...
Artikelnummer: CSB-BP010053RA.1
Organism: Rattus norvegicus (Rat). Source: Baculovirus. Expression Region: 23-429aa. Protein Length: Extracellular Domain. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: SQVRQKCHNG TYEISVLMMD NSAYKEPLQN LRDAVEEGLD IVRKRLREAE LNVTVNATFI YSDGLIHKSG DCRSSTCEGL DLLREITRDR...
| Schlagworte: | GC-C, Guc2c, Gucy2c, EC=4.6.1.2, STA receptor, Guanylyl cyclase C, Intestinal guanylate cyclase, Heat-stable enterotoxin... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | rat |
| MW: | 50.4 kD |
ab 489,00 €
Heat-stable enterotoxin receptor (GUCY2C), partial,...
Artikelnummer: CSB-BP3779MOV.1
Organism: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Source: Baculovirus. Expression Region: 24-430aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: SQVSQNCHNG SYEISVLMMD NSAFAEPLEN VEDAVNEGLE IVRGRLQNAG LNVTVNASFM YSDGLIHNSG DCRSSTCEGL DLLRKISNAK RMGCVLMGPS...
| Schlagworte: | Guanylate cyclase, Recombinant Macaca fascicularis Heat-stable enterotoxin receptor (GUCY2C), partial |
| Anwendung: | Activity not tested |
| Exprimiert in: | Insect cells |
| Ursprungsart: | Cynomolgus monkey |
| MW: | 51.7 kD |
ab 489,00 €
Heat-stable enterotoxin receptor (Gucy2c), partial, rat,...
Artikelnummer: CSB-EP010053RA.1
Organism: Rattus norvegicus (Rat). Source: E.coli. Expression Region: 23-429aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: SQVRQKCHNG TYEISVLMMD NSAYKEPLQN LRDAVEEGLD IVRKRLREAE LNVTVNATFI YSDGLIHKSG DCRSSTCEGL DLLREITRDR KMGCVLMGPS CTYSTFQMYL...
| Schlagworte: | GC-C, Guc2c, Gucy2c, EC=4.6.1.2, STA receptor, Guanylyl cyclase C, Intestinal guanylate cyclase, Heat-stable enterotoxin... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | rat |
| MW: | 51.9 kD |
ab 364,00 €