Zu "K12318" wurden 58 Artikel gefunden!
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ODQ
Artikelnummer: Cay81410-10
ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase. The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.Formal Name: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. CAS...
| Schlagworte: | 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one |
| Anwendung: | Guanylyl cyclase inhibitor |
| CAS | 41443-28-1 |
| MW: | 187.2 D |
ab 49,00 €
Cinaciguat
Artikelnummer: TGM-T1984-100mg
Description: Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure. Target: Guanylate cyclase. Smiles: O(CC1=CC=C(CCC2=CC=CC=C2)C=C1)C3=C(CCN(CC4=CC=C(C(O)=O)C=C4)CCCCC(O)=O)C=CC=C3. References:...
| Schlagworte: | BAY 58-2667 |
| Anwendung: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 329773-35-5 |
| MW: | 565.7 D |
ab 42,00 €
Cinaciguat hydrochloride
Artikelnummer: TGM-T1984L-100mg
Description: Cinaciguat( BAY582667, BAY58-2667) is a soluble guanosine cyclase activator that can prevent cardiac dysfunction in rat models of type 1 diabetes. Target: Others. Smiles: Cl.OC(=O)CCCCN(CCc1ccccc1OCc1ccc(CCc2ccccc2)cc1)Cc1ccc(cc1)C(O)=O. References: Mátyás C, Németh BT, Oláh A, Hidi L, Birtalan E,...
| Schlagworte: | BAY 58-2667, BAY-58-2667, Cinaciguat HCl, BAY58-2667, BAY-582667, BAY 582667, BAY582667 |
| Anwendung: | Soluble guanylate cyclase activator |
| CAS | 646995-35-9 |
| MW: | 602.17 D |
ab 112,00 €
ODQ
Artikelnummer: TGM-T19777-100mg
Description: ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor. Target: Apoptosis, Guanylate cyclase, Others. Smiles: O=c1onc2cnc3ccccc3n12. References: Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl...
| Anwendung: | Soluble guanylyl cyclase inhibitor |
| CAS | 41443-28-1 |
| MW: | 187.15 D |
ab 42,00 €
BAY 41-2272
Artikelnummer: TGM-T6775-100mg
Description: BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. Target: Guanylate cyclase. Smiles: Nc1nc(ncc1C1CC1)-c1nn(Cc2ccccc2F)c2ncccc12. References: Becker EM, et al. BMC Pharmacol. 2001, 1, 13.
| Anwendung: | Soluble guanylate cyclase activator |
| CAS | 256376-24-6 |
| MW: | 360.39 D |
ab 31,00 €
Riociguat
Artikelnummer: TGM-T6968-5mg
Description: Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension. Target: Guanylate cyclase. Smiles: COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12. References: Schermuly RT, et al. Eur Respir...
| Schlagworte: | BAY 632521 |
| Anwendung: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 625115-55-1 |
| MW: | 422.42 D |
ab 37,00 €
Vericiguat
Artikelnummer: TGM-T17226-100mg
Description: Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator. Target: Guanylate cyclase. Smiles: COC(=O)Nc1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncc(F)cc12. References: Follmann M, et al. Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment...
| Schlagworte: | BAY1021189 |
| Anwendung: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 1350653-20-1 |
| MW: | 426.38 D |
ab 42,00 €
NS-2028
Artikelnummer: TGM-T16344-100mg
Description: NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM),...
| Anwendung: | Guanylyl cyclase inhibitor |
| CAS | 204326-43-2 |
| MW: | 269.05 D |
ab 34,00 €
Olinciguat
Artikelnummer: TGM-T16383-100mg
Description: Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay. Target: Guanylate cyclase. Smiles: NC(=O)[C@](O)(CNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(F)(F)F. References:...
| Schlagworte: | IW-1701 |
| Anwendung: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 1628732-62-6 |
| MW: | 509.39 D |
ab 187,00 €
Praliciguat
Artikelnummer: TGM-T16569-100mg
Description: Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator. Target: Guanylate cyclase, Others. Smiles:...
| Schlagworte: | IW-1973 |
| Anwendung: | Targets guanylate cyclase soluble subunit alpha [EC:4.6.1.2] (GUCY1A) |
| CAS | 1628730-49-3 |
| MW: | 534.36 D |
ab 152,00 €
Ataciguat
Artikelnummer: TGM-T21607-100mg
Description: Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator. Target: Others, Guanylate cyclase. Smiles: N(S(=O)(=O)C1=CC=C(Cl)S1)C2=C(C(NC3=CC=C(S(=O)(=O)N4CCOCC4)C=C3)=O)C=C(Cl)C=C2. References: Martinelli AM, et, al. In Endothelial Cells, the Activation or...
| Schlagworte: | HMR-1766 |
| Anwendung: | sGC, oxidized, heme-free, form, activator |
| CAS | 254877-67-3 |
| MW: | 576.49 D |
ab 45,00 €
Lificiguat
Artikelnummer: TGM-T4381-100mg
Description: Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). Target: HIF, Guanylate cyclase, Others. Smiles: OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12. References: Martin E,etal.YC-1 activation of human...
| Schlagworte: | YC-1 |
| Anwendung: | Soluble guanylyl cyclase (sGC) activator |
| CAS | 170632-47-0 |
| MW: | 304.34 D |
ab 43,00 €