Zu "K11836" wurden 34 Artikel gefunden!
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Anti-USP5/IsoT
Artikelnummer: A301-542A
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an...
| Schlagworte: | Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Spautin-1
Artikelnummer: Cay17769-10
Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM). It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the...
| Schlagworte: | 6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine |
| Anwendung: | Autophagy inhibitor, USP10 / USP13 inhibitor |
| CAS | 1262888-28-7 |
| MW: | 271.3 D |
ab 43,00 €
Anti-USP5/IsoT
Artikelnummer: A301-543A
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an...
| Schlagworte: | Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5,... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Z-LRGG-AMC (trifluoroacetate salt)
Artikelnummer: Cay26641-5
Z-LRGG-AMC is a fluorogenic substrate for isopeptidase T. Upon enzymatic cleavage by isopeptidase T, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify isopeptidase T activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.Formal Name:...
| Schlagworte: | Z-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin, Z-Leu-Arg-Gly-Gly-AMC,... |
| Anwendung: | Fluorogenic isopeptidase T substrate |
| MW: | 692.8 D |
ab 142,00 €
USP5 (IsoT), active human recombinant protein, N-terminal...
Artikelnummer: BPS-80355
Human USP5 (Ubiquitin-Specific Protease 5) or Isopeptidase T (IsoT), GenBank Accession No. NM_001098536, amino-acids 2-858(end) with an N-terminal FLAG-tag, MW=96 kDa, expressed in a baculovirus-infected Sf9 cell expression system.
| Schlagworte: | USP5, ISOT, EC=3.4.19.12, Isopeptidase T, Ubiquitin thioesterase 5, Deubiquitinating enzyme 5, Ubiquitin carboxyl-terminal... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 96 kD |
628,00 €
Ubiquitin Isopeptidase Inhibitor I
Artikelnummer: Cay21006-10
Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 µM). It has also been shown to induce necrosis in apoptosis-resistant DKO...
| Schlagworte: | NSC 144303, tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide |
| Anwendung: | Ubiquitin isopeptidase inhibitor |
| CAS | 108477-18-5 |
| MW: | 414.4 D |
ab 130,00 €
Anti-USP5/IsoT (IHC)
Artikelnummer: IHC-00313
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an...
| Schlagworte: | Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5,... |
| Anwendung: | IHC, IHC-IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Anti-USP13
Artikelnummer: E-AB-63322.120
Protein function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates...
| Schlagworte: | Anti-ISOT3, Anti-USP13, Anti-ISOT-3, EC=3.4.19.12, Anti-Isopeptidase T-3, Anti-Ubiquitin thioesterase 13,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 198,00 €
Anti-USP5
Artikelnummer: ARG59512.100
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an...
| Schlagworte: | Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
624,00 €
Anti-USP5, clone 1340CT704.170.140
Artikelnummer: ARG55002.100
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an...
| Schlagworte: | Anti-ISOT, Anti-USP5, EC=3.4.19.12, Anti-Isopeptidase T, Anti-Ubiquitin thioesterase 5, Anti-Deubiquitinating enzyme 5,... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
624,00 €
Anti-USP13
Artikelnummer: ARG41839.100
Protein function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates...
| Schlagworte: | Anti-ISOT3, Anti-USP13, Anti-ISOT-3, EC=3.4.19.12, Anti-Isopeptidase T-3, Anti-Ubiquitin thioesterase 13,... |
| Anwendung: | FC, ICC, IF, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
624,00 €
Anti-USP13
Artikelnummer: ARG41876.100
Protein function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates...
| Schlagworte: | Anti-ISOT3, Anti-USP13, Anti-ISOT-3, EC=3.4.19.12, Anti-Isopeptidase T-3, Anti-Ubiquitin thioesterase 13,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse, rat |
624,00 €