Zu "K11480" wurden 41 Artikel gefunden!
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TAK-901
Artikelnummer: TGM-T2709-25mg
Description: TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others. Target: JAK, Aurora Kinase, CDK, Src. Smiles: CCS(=O)(=O)c1cccc(c1)-c1cc(C(=O)NC2CCN(C)CC2)c(C)c2[nH]c3ncc(C)cc3c12. References: Pamela...
| Schlagworte: | TAK901 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 934541-31-8 |
| MW: | 504.64 D |
ab 65,00 €
Aurora kinase inhibitor-9
Artikelnummer: TGM-T62789-25mg
Description: Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B bipolar kinase inhibitor with an IC50 of 0.093 µM for Aurora A and 0.09 µM for Aurora B, demonstrating broad-spectrum anti-proliferative activity. Target: Others. Smiles: N(C=1C2=C(N=CC1C(OCC)=O)C=C(Cl)C=C2Cl)C3=CC(S(NC)(=O)=O)=CC=C3
| Anwendung: | Aurora kinase inhibitor |
| CAS | 2419107-09-6 |
| MW: | 454.33 D |
ab 1.520,00 €
Anti-Phospho-AURKC (Thr236/202)
Artikelnummer: CSB-PA238732.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-AIE2, Anti-phospho-ARK-3, Anti-phospho-AURKC, Anti-phospho-Aurora 3, EC=2.7.11.1, Anti-phospho-Aurora kinase... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
340,00 €
Anti-AURKC
Artikelnummer: CSB-PA554629.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: AURKC. Antigen Species: Human
| Schlagworte: | Anti-AIE2, Anti-ARK-3, Anti-AURKC, Anti-Aurora 3, EC=2.7.11.1, Anti-Aurora kinase C, Anti-Aurora-related kinase 3,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
AMG 900
Artikelnummer: Cay19176-5
Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Their expression is elevated in a variety of human cancers. AMG 900 is an orally bioavailable, selective Aurora kinase inhibitor with IC50 values of 5, 4, and 1 nM for Aurora A, B, and C, respectively....
| Schlagworte: | N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 945595-80-2 |
| MW: | 503.6 D |
ab 61,00 €
GSK1070916
Artikelnummer: Cay22953-5
GSK1070916 is a potent and ATP-competitive inhibitor of Aurora kinases B and C (Kis = 0.38 and 1.5 nM, respectively). It is >250-fold selective for Aurora B and C over Aurora A. GSK1070916 inhibits proliferation of A549 lung cancer cells in vitro (EC50 = 7 nM). It also inhibits proliferation in a panel of 100 tumor...
| Schlagworte: | N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl-... |
| Anwendung: | Aurora B/C kinase inhibitor |
| CAS | 942918-07-2 |
| MW: | 507.6 D |
ab 55,00 €
Tozasertib
Artikelnummer: SYN-1092-M005
Soluble in DMSO or ethanol. In mammals, three Aurora kinases, Aurora A, Aurora B, and Aurora C, are expressed. Aurora C expression is mainly restricted to testis, where it functions during meiosis, whereas Aurora A and B play key functions regulating mitosis. Aurora A is localized to the centrosome and spindle...
| Schlagworte: | MK-0457, VX-680 |
| Anwendung: | Aurora inhibitor |
| CAS | 639089-54-6 |
| MW: | 464,6 D |
ab 77,00 €
Anti-AURKC, N-terminal
Artikelnummer: ARG65206.100
Protein function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced...
| Schlagworte: | Anti-AIE2, Anti-ARK-3, Anti-AURKC, Anti-Aurora 3, EC=2.7.11.1, Anti-Aurora kinase C, Anti-Aurora-related kinase 3,... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
822,00 €
CYC-116
Artikelnummer: LKT-C9708.5
CYC-116 inhibits aurora kinases B and C (AurB, AurC), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. CYC-116 inhibits proliferation in a variety of in vitro cancer models.
| Anwendung: | Aurora kinase B / C inhibitor |
| CAS | 693228-63-6 |
| MW: | 368.46 D |
ab 164,00 €
Anti-AURKC
Artikelnummer: NSJ-F53762-0.4ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in...
| Schlagworte: | Anti-AIE2, Anti-ARK-3, Anti-AURKC, Anti-Aurora 3, EC=2.7.11.1, Anti-Aurora kinase C, Anti-Aurora-related kinase 3,... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
Anti-AURKC
Artikelnummer: NSJ-R35129-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Aurora kinase C, AIE2, AIK3, ARK3, AurC Protein function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis....
| Schlagworte: | Anti-AIE2, Anti-ARK-3, Anti-AURKC, Anti-Aurora 3, EC=2.7.11.1, Anti-Aurora kinase C, Anti-Aurora-related kinase 3,... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
790,00 €
Danusertib
Artikelnummer: Cay18387-10
Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those...
| Schlagworte: | PHA-739358,... |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 827318-97-8 |
| MW: | 474.6 D |
ab 53,00 €