Zu "K11448" wurden 27 Artikel gefunden!
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GSK-J4 (hydrochloride)
Artikelnummer: Cay12073-5
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 (hydrochloride) is an ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (Cay-12054) with an...
| Schlagworte: | N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine, ethyl ester, monohydrochloride |
| Anwendung: | Histone demethylase inhibitor |
| CAS | 1797983-09-5 |
| MW: | 454 D |
ab 77,00 €
JIB-04
Artikelnummer: Cay15338-5
JIB-04 is a pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC50s values = 230, 340, 435, 445, 855 and 1,100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively). It does not inhibit histone deacetylases and has minimal effect on the iron-containing enzymes methylcytosine...
| Schlagworte: | JHDM Inhibitor VII, NSC 693627, phenyl-2-pyridinyl-methanone, (E,E)-2-(5-chloro-2-pyridinyl)hydrazone |
| Anwendung: | Jumonji histone demethylase inhibitor |
| CAS | 199596-05-9 |
| MW: | 308.8 D |
ab 109,00 €
JMJD3, active human, C-terminal DDDK (Flag) Tag
Artikelnummer: BPS-50115
Human JMJD3/KDM6B histone demethylase (a.a. 1000-end) expressed in Sf9 cells. Methylation of Lys27 of histone H3 (H3K27) is a silencing mark associated with imprinting and X chromosome activation. JMJD3 is a histone demethylase that demethylates di- and trimethyl-lysine 27 on histone H3, JMJD3 also plays important...
| Schlagworte: | KDM6B, JMJD3, Lysine demethylase 6B, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji... |
| Anwendung: | Enzyme kinetics, inhibitor screening, HTS |
| MW: | 71 kD |
701,00 €
GSK-J1 (sodium salt)
Artikelnummer: Cay12054-5
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50s = 18 and 56 µM, respectively as measured by mass...
| Schlagworte: | N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine, monosodium salt |
| Anwendung: | JMJD3 inhibitor |
| CAS | 1797832-71-3 |
| MW: | 411.4 D |
ab 43,00 €
Anti-Kdm6b
Artikelnummer: NSJ-F52856-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene...
| Schlagworte: | Anti-Jmjd3, Anti-Kdm6b, EC=1.14.11.-, Anti-Lysine-specific demethylase 6B, Anti-JmjC domain-containing protein 3,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 326,00 €
JMJD3 chemiluminescent assay kit
Artikelnummer: BPS-50406
The JMJD3 Chemiluminescent Assay Kit is designed to measure JMJD3 activity for screening and profiling applications. JMJD3 is a JmjC-domain protein that exhibits demethylation activity toward di- and trimethyl-lysine 27 (H3K27me2/3) on histone H3. The JMJD3 Assay Kit comes in a convenient format, with 8-well strips...
| Schlagworte: | JMJD3, KDM6B, |
| Anwendung: | Enzyme kinetics, HTS |
1.065,00 €
JMJD3 homogeneous assay kit
Artikelnummer: BPS-50416-1
The JMJD3 Homogeneous Assay Kit is designed to measure activity of the JMJD3 for screening and profiling applications. JMJD3 is a JmjC-domain protein that exhibits demethylation activity toward di- and trimethyl-lysine 27 (H3K27me2/3) on histone H3. The JMJD3 Homogeneous Assay Kit comes in a convenient AlphaLISA®...
| Schlagworte: | KDM6B, JMJD3, Lysine demethylase 6B, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji... |
| Anwendung: | Enzyme kinetics, HTS |
ab 1.021,00 €
Anti-JMJD3 (KDM6B)
Artikelnummer: NSJ-F40552-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A...
| Schlagworte: | Anti-Jmjd3, Anti-Kdm6b, EC=1.14.11.-, Anti-Lysine-specific demethylase 6B, Anti-JmjC domain-containing protein 3,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 326,00 €
Anti-KDM6B
Artikelnummer: NSJ-F53139-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene...
| Schlagworte: | Anti-JMJD3, Anti-KDM6B, EC=1.14.11.-, Anti-Lysine demethylase 6B, Anti-Lysine-specific demethylase 6B, Anti-JmjC... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
ab 326,00 €
GSK-J1
Artikelnummer: SYN-3030-M001
GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other...
| Schlagworte: | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine |
| Anwendung: | H3K27 histone demethylase JMJD3 (KDM6B) / UTX (KDM6A) inhibitor |
| CAS | 1373422-53-7 |
| MW: | 389.5 D |
ab 79,00 €
GSK J4 HCl
Artikelnummer: BPS-27627-1
GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.
| Schlagworte: | ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate, |
| Anwendung: | Cell-permeable GSK J1 prodrug (UTX / KDM6B inhibitor) |
| MW: | 454 D |
ab 371,00 €
Anti-KDM6B / JMJD3
Artikelnummer: ARG59524.100
Protein function: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in...
| Schlagworte: | Anti-Kdm6b, Anti-Jmjd3, EC=1.14.11.-, Anti-Lysine-specific demethylase 6B, Anti-JmjC domain-containing protein 3,... |
| Anwendung: | ICC, IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
624,00 €