Zu "K11430" wurden 162 Artikel gefunden!
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NEU
Zeprumetostat
Artikelnummer: Cay44976-1
An EZH2 inhibitor (IC50 = 0.87 nM for the wild-type enzyme), selective for EZH2 over a panel of 24 histone and DNA methyltransferases (IC50s = >10,000 nM for all) but also inhibits EZH1 (IC50 = 19.1 nM), inhibits EZH2Y641C, EZH2Y641F, EZH2Y641N, EZH2Y641S, and EZH2Y641G (IC50s = 16.8, 2.68, 1.79, 5.07, and 1.13 nM,...
| Schlagworte: | SHR2554, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3- pyridinyl)methyl]-5-ethyl-6-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-... |
| Anwendung: | EZH2 inhibitor |
| CAS | 2098545-98-1 |
| MW: | 548.73 D |
ab 201,00 €
Anti-Recombinant EZH2, clone 12G12
Artikelnummer: E-AN300717L.100
EZH2(enhancer of zeste 2 polycomb repressive complex 2 subunit) Homo sapiens This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This...
| Schlagworte: | Anti-EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine N-methyltransferase 6, Anti-Histone-lysine... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-EZH2
Artikelnummer: NSJ-F53753-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit....
| Schlagworte: | Anti-EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine N-methyltransferase 6, Anti-Histone-lysine... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
361,00 €
Anti-EZH2
Artikelnummer: NSJ-RQ5256
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme encoded by EZH2gene. It is mapped to 7q36.1. This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved...
| Schlagworte: | Anti-EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine N-methyltransferase 6, Anti-Histone-lysine... |
| Anwendung: | WB, FC, IP, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
PF-06726304
Artikelnummer: Cay44260-1
PF-06726304 is an inhibitor of enhancer of zeste homolog 2 (EZH2, Ki = 0. nM). In vivo, PF-06726304 (200 and 300 mg/kg) reduces tumor volume and intratumor histone methylation in a Karpas-422 mouse xenograft model. InChI:...
| Schlagworte: | 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoqui... |
| Anwendung: | EZH2 inhibitor |
| CAS | 1616287-82-1 |
| MW: | 446.33 D |
ab 53,00 €
GSK126
Artikelnummer: Cay15415-1
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK126 is a selective, S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57...
| Schlagworte: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-... |
| Anwendung: | Selective EZH2 methyltransferase inhibitor |
| CAS | 1346574-57-9 |
| MW: | 526.7 D |
ab 93,00 €
UNC1999
Artikelnummer: Cay14621-1
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 and >1,000-fold selective over other...
| Schlagworte: | N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-1H-... |
| Anwendung: | Cell-permeable EZH2 inhibitor |
| CAS | 1431612-23-5 |
| MW: | 569.8 D |
ab 49,00 €
3-Deazaneplanocin A (hydrochloride)
Artikelnummer: Cay11102-500
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally...
| Schlagworte: | 2,3-DMMC, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol, monohydrochloride |
| CAS | 120964-45-6 |
| MW: | 298.7 D |
ab 138,00 €
GSK343
Artikelnummer: Cay14094-1
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK343 is a cell-permeable EZH2 inhibitor (IC50 = 4 nM) that is 60-fold selective over EZH1 and >1,000-fold selective over other...
| Schlagworte: | N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1... |
| Anwendung: | Cell-permeable EZH2 inhibitor |
| CAS | 1346704-33-3 |
| MW: | 541.7 D |
ab 56,00 €
PF-06821497
Artikelnummer: Cay42500-1
PF-06821497 is an enhancer of zeste homolog 2 (EZH2) inhibitor (Ki = <0. nM for EZH2Y641N). It is selective for EZH2 over a panel of 14 methyltransferases, 40 kinases, and 79 additional targets at 10 µM but does bind to EZH1 (Ki = 70 nM). PF-06821497 reduces trimethylation of lysine 27 on histone H3 (H3K27Me3) in,...
| Schlagworte: | Mevrometostat,... |
| Anwendung: | EZH2 inhibitor, antineoplastic, histone methyltransferase inhibitor |
| CAS | 1844849-10-0 |
| MW: | 467.34 D |
ab 88,00 €
CPI-1205
Artikelnummer: Cay22962-1
| Schlagworte: | N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]et... |
| Anwendung: | EZH2 inhibitor |
| CAS | 1621862-70-1 |
| MW: | 518.6 D |
ab 68,00 €
EZH2 chemiluminescent assay kit
Artikelnummer: BPS-52009L
The EZH2/EED/SUZ12/RbAp48/AEBP2 Direct Activity Assay kit is designed to measure EZH2/EED/SUZ12/RbAp48/AEBP2 activity using purified enzyme complex or EZH2/EED/SUZ12/RbAp48/AEBP2 extracts. The EZH2/EED/SUZ12/RbAp48/AEBP2 Direct Activity Assay Kit comes in a convenient format, with a 96-well plate precoated with...
| Schlagworte: | KMT6, ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6, Histone-lysine N-methyltransferase EZH2, |
| Anwendung: | Enzyme kinetics, HTS |
2.569,00 €