Zu "K11430" wurden 142 Artikel gefunden!
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Anti-mes-2
Artikelnummer: CSB-PA515708XA01CXY.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally...
| Schlagworte: | Anti-E(z) homolog, EC=2.1.1.356, Anti-Maternal-effect sterile protein 2, Anti-Histone-lysine N-methyltransferase mes-2,... |
| Anwendung: | ELISA, WB |
| Spezies-Reaktivität: | Caenorhabditis elegans |
ab 147,00 €
Anti-EZH2
Artikelnummer: ABS-KC-3192.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1,...
| Schlagworte: | Anti-Histone-lysine N-methyltransferase EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-EZH2
Artikelnummer: ABS-OC-533.100
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1,...
| Schlagworte: | Anti-Histone-lysine N-methyltransferase EZH2, Anti-ENX-1, Anti-Enhancer of zeste homolog 2, Anti-Lysine... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
CPI-1205
Artikelnummer: TGM-T8510-10mg
Description: CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 µM, EC50 : 0.032 µM) . Target: Histone Methyltransferase. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCN(CC(F)(F)F)CC4. References: Vaswani RG, et al. Identification of...
| Schlagworte: | Lirametostat |
| Anwendung: | EZH2 inhibitor |
| CAS | 1621862-70-1 |
| MW: | 518.57 D |
ab 84,00 €
EPZ005687
Artikelnummer: TGM-T1905-100mg
Description: EPZ005687, a potent and selective inhibitor of EZH2. Target: Histone Methyltransferase. Smiles: Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1. References: Knutson SK, et al. Nat Chem Biol, 2012, 8(11), 890-896.
| Anwendung: | Lysine methyltranferase EZH2 inhibitor |
| CAS | 1396772-26-1 |
| MW: | 539.67 D |
ab 54,00 €
GSK503
Artikelnummer: TGM-T1775-100mg
Description: GSK-503, a potent EZH2 inhibitor, has potential antitumor activity. Target: Histone Methyltransferase. Smiles: CC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Béguelin W, et al. Cancer Cell. 2013, 23(5), 677-692
| Anwendung: | EZH2 inhibitor |
| CAS | 1346572-63-1 |
| MW: | 526.67 D |
ab 31,00 €
3-deazaneplanocin A HCl
Artikelnummer: TGM-T6360-100mg
Description: 3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor. Target: Others, Histone Methyltransferase. Smiles: Cl.Nc1nccc2n(cnc12)C1C=C(CO)C(O)C1O. References: Glazer RI, et al. Biochem Pharmacol, 1986, 35(24), 4523-4527.
| Anwendung: | Apoptosis inducer, trimethylation inhibitor |
| CAS | 120964-45-6 |
| MW: | 298.73 D |
ab 86,00 €
CPI-169 racemate
Artikelnummer: TGM-T6809-100mg
Description: CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles: CCS(=O)(=O)N1CCC(CC1)C(C)n1c(C)c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c2ccccc12....
| Schlagworte: | CPI-169, CPI 169, CPI169 |
| Anwendung: | EZH2 inhibitor |
| CAS | 1450655-76-1 |
| MW: | 528.66 D |
ab 52,00 €
CPI-360
Artikelnummer: TGM-T6810-100mg
Description: CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 µM, EC50: 0.080 µM) that shows antitumor activity in an EZH200-dependent tumor xenograft model. Target: Histone Methyltransferase, Apoptosis. Smiles: [C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCOCC4. References: Vatolin S, et al....
| Schlagworte: | CPI360, Synonym 2, Synonym 2, CPI 360 |
| Anwendung: | Selective EZH2 inhibitor |
| CAS | 1802175-06-9 |
| MW: | 437.53 D |
ab 75,00 €
GSK343
Artikelnummer: TGM-T6059-100mg
Description: GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases. Target: Histone Methyltransferase, Autophagy. Smiles:...
| Anwendung: | Cell-permeable EZH2 inhibitor |
| CAS | 1346704-33-3 |
| MW: | 541.69 D |
ab 55,00 €
GSK126
Artikelnummer: Cay15415-1
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK126 is a selective, S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57...
| Schlagworte: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-... |
| Anwendung: | Selective EZH2 methyltransferase inhibitor |
| CAS | 1346574-57-9 |
| MW: | 526.7 D |
ab 85,00 €
PF-06821497
Artikelnummer: TGM-T12430-100mg
Description: PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition. Target: Histone Methyltransferase. Smiles: ClC1=C2C(=C(Cl)C=C1[C@H](OC)C3COC3)CCN(CC4=C(OC)C=C(C)NC4=O)C2=O. References: Kung PP, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2)...
| Anwendung: | Targets [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356] (EZH2) |
| CAS | 1844849-10-0 |
| MW: | 467.34 D |
ab 97,00 €