Zu "K11424" wurden 28 Artikel gefunden!
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Anti-Recombinant WHSC1, clone A601
Artikelnummer: E-AN301885L.100
WHSC1, also known as MMSET or NSD2, is a SET domain containing histone lysine methyltransferase that can di- and trimethylate histone H3 at lysine 36 (H3K36). WHSC1 mRNA is highly expressed in embryonic tissues, especially those with high degrees of proliferation, whereas in adult tissues, the mRNA is primarily...
| Schlagworte: | Anti-NSD2, Anti-Protein trithorax-5, Anti-Nuclear SET domain-containing protein 2, Anti-Histone-lysine N-methyltransferase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
MR837
Artikelnummer: Cay43711-10
MR837 is an inhibitor of the histone-lysine N-methyltransferase NSD2 (IC50 = 24. µM). It binds to the NSD2 PWWP1 domain (Kd = 7 µM), which binds methylated histones, and inhibits the protein-protein interaction between NSD2 and histone H3. in U2OS cells (IC50 = 17. µM). InChI:...
| Schlagworte: | 4-cyano-N-cyclopropyl-N-(2-thienylmethyl)-benzamide |
| Anwendung: | NSD2 ([histone H3]-lysine36 N-dimethyltransferase) inhibitor |
| CAS | 1210906-48-1 |
| MW: | 282.36 D |
ab 84,00 €
Anti-NSD2
Artikelnummer: A303-093A
Protein function: Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. [The UniProt Consortium]
| Schlagworte: | Anti-NSD2, Anti-WHSC1, Anti-MMSET, Anti-KIAA1090, EC=2.1.1.43, Anti-Protein trithorax-5, Anti-Histone-lysine... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
UNC8153 (trifluoroacetate salt)
Artikelnummer: Cay38932-1
UNC8153 is a degrader of the histone-lysine N-methyltransferase NSD2. It induces its degradation of NSD2 with a 50% degradation constant (DC50) value of 350 nM and is selective for NSD2 over NSD1 and NSD3 at 20 µM. UNC8153 (10 µM) induces NSD2 degradation and reduces histone H3 lysine 36 dimethylation (H3K36me2) in...
| Schlagworte: | N-[[4-[[[4-[[(6-aminohexyl)amino]carbonyl]phenyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benz... |
| Anwendung: | NSD2 degrader |
| CAS | 2929304-61-8 |
| MW: | 697.7 D |
ab 110,00 €
UNC6934
Artikelnummer: TGM-T9584-1mg
Description: UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. Target: Histone Methyltransferase, HIF/HIF Prolyl-Hydroxylase. Smiles: O=C(Nc1ccncn1)c1ccc(CN(C2CC2)C(=O)c2ccc3NC(=O)COc3c2)cc1. References: Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2...
| Anwendung: | NSD2-H3K36me2 nucleosome interaction inhibitor |
| CAS | 2561494-77-5 |
| MW: | 443.45 D |
ab 40,00 €
NSD2 (catalytic domain), active human recombinant protein
Artikelnummer: BPS-51026
Active human NSD2 (MMSET) (GenBank Accession No. NM_133330), amino-acids 941-1240 with N-terminal GST tag, MW = 62 kDa, expressed in E. coli.
| Schlagworte: | MMSET, KIAA1090, Protein trithorax-5, Nuclear SET domain-containing protein 2, Histone-lysine N-methyltransferase NSD2,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 62 kD |
678,00 €
NSD2 Chemiluminescent Assay Kit
Artikelnummer: BPS-79359
The NSD2 Chemiluminescent Assay Kit is designed to measure NSD2 activity for screening and profiling applications. The key to the NSD2 Chemiluminescent Activity Assay Kit is a highly specific antibody that recognizes methylated residue of Histone H3. With this kit, only three simple steps are required for...
| Schlagworte: | WHSC1, Wolf-Hirschhorn Syndrome Candidate 1, MMSET, Multiple Myeloma SET Domain Containing Protein, NSD2, Nuclear SET... |
| Anwendung: | Enzyme kinetics, HTS |
| Spezies-Reaktivität: | human |
1.679,00 €
Anti-NSD2, clone CL1057
Artikelnummer: ATA-AMAb90848.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Schlagworte: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Anwendung: | ICC, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 246,00 €
Anti-NSD2, clone CL1063
Artikelnummer: ATA-AMAb90851.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Schlagworte: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-NSD2
Artikelnummer: ATA-HPA015801.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Schlagworte: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
PTD2 (trifluoroacetate salt)
Artikelnummer: Cay38842-1
PTD2 is a peptide inhibitor of the histone methyltransferase Wolf-Hirschhorn syndrome candidate 1 (WHSC1, IC50 = 22 µM) that was derived from the histone 4 sequence.Formal Name:...
| Schlagworte: | (S)-2-(2-((5S,8S)-8-(2-acetamidoacetamido)-9-methyl-6,7-dioxodecan-5-yl)hydrazineyl)-N-((2S,3S)-1-amino-3-methyl-1-oxopent... |
| Anwendung: | WHSC1 peptide inhibitor |
| MW: | 597.8 D |
ab 78,00 €
UNC7145
Artikelnummer: Cay40166-1
UNC7145 is an inactive derivative of the histone-lysine N-methyltransferase NSD2 inhibitor UNC6934 that has been used as a negative control for the histone methyltransferase activity of NSD2.Formal Name:...
| Schlagworte: | 3,4-dihydro-N-(1-methylethyl)-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide |
| Anwendung: | Inactive UNC6934 derivative, negative control |
| CAS | 2561494-78-6 |
| MW: | 445.5 D |
ab 44,00 €