Zu "K11424" wurden 17 Artikel gefunden!
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UNC7145
Artikelnummer: Cay40166-1
UNC7145 is an inactive derivative of the histone-lysine N-methyltransferase NSD2 inhibitor UNC6934 that has been used as a negative control for the histone methyltransferase activity of NSD2.Formal Name:...
| Schlagworte: | 3,4-dihydro-N-(1-methylethyl)-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide |
| Anwendung: | Inactive UNC6934 derivative, negative control |
| CAS | 2561494-78-6 |
| MW: | 445.5 D |
ab 38,00 €
PTD2 (trifluoroacetate salt)
Artikelnummer: Cay38842-1
PTD2 is a peptide inhibitor of the histone methyltransferase Wolf-Hirschhorn syndrome candidate 1 (WHSC1, IC50 = 22 µM) that was derived from the histone 4 sequence.Formal Name:...
| Schlagworte: | (S)-2-(2-((5S,8S)-8-(2-acetamidoacetamido)-9-methyl-6,7-dioxodecan-5-yl)hydrazineyl)-N-((2S,3S)-1-amino-3-methyl-1-oxopent... |
| Anwendung: | WHSC1 peptide inhibitor |
| MW: | 597.8 D |
ab 68,00 €
UNC8153 (trifluoroacetate salt)
Artikelnummer: Cay38932-1
UNC8153 is a degrader of the histone-lysine N-methyltransferase NSD2. It induces its degradation of NSD2 with a 50% degradation constant (DC50) value of 350 nM and is selective for NSD2 over NSD1 and NSD3 at 20 µM. UNC8153 (10 µM) induces NSD2 degradation and reduces histone H3 lysine 36 dimethylation (H3K36me2) in...
| Schlagworte: | N-[[4-[[[4-[[(6-aminohexyl)amino]carbonyl]phenyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benz... |
| Anwendung: | NSD2 degrader |
| CAS | 2929304-61-8 |
| MW: | 697.7 D |
ab 96,00 €
Anti-NSD2
Artikelnummer: A303-093A
Protein function: Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. [The UniProt Consortium]
| Schlagworte: | Anti-NSD2, Anti-WHSC1, Anti-MMSET, Anti-KIAA1090, EC=2.1.1.43, Anti-Protein trithorax-5, Anti-Histone-lysine... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
NSD2 (catalytic domain), active human recombinant protein
Artikelnummer: BPS-51026
Active human NSD2 (MMSET) (GenBank Accession No. NM_133330), amino-acids 941-1240 with N-terminal GST tag, MW = 62 kDa, expressed in E. coli.
| Schlagworte: | MMSET, KIAA1090, Protein trithorax-5, Nuclear SET domain-containing protein 2, Histone-lysine N-methyltransferase NSD2,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 62 kD |
664,00 €
NSD2 Chemiluminescent Assay Kit
Artikelnummer: BPS-79359
The NSD2 Chemiluminescent Assay Kit is designed to measure NSD2 activity for screening and profiling applications. The key to the NSD2 Chemiluminescent Activity Assay Kit is a highly specific antibody that recognizes methylated residue of Histone H3. With this kit, only three simple steps are required for...
| Schlagworte: | WHSC1, Wolf-Hirschhorn Syndrome Candidate 1, MMSET, Multiple Myeloma SET Domain Containing Protein, NSD2, Nuclear SET... |
| Anwendung: | Enzyme kinetics, HTS |
| Spezies-Reaktivität: | human |
1.603,00 €
Anti-WHSC1
Artikelnummer: E-AB-62262.120
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of...
| Schlagworte: | Anti-MMSET, Anti-KIAA1090, EC=2.1.1.43, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 198,00 €
Anti-NSD2, clone CL1057
Artikelnummer: ATA-AMAb90848.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Schlagworte: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Anwendung: | ICC, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 335,00 €
Anti-NSD2, clone CL1063
Artikelnummer: ATA-AMAb90851.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Schlagworte: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 300,00 €
Anti-NSD2
Artikelnummer: ATA-HPA015801.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Schlagworte: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €
NSD2 Chemiluminescent Assay Kit
Artikelnummer: BPS-53009
The NSD2 Chemiluminescent Assay Kit is designed to measure NSD2 activity for screening and profiling applications. The NSD2 Chemiluminescent Assay Kit comes in a convenient format, with 96-well plate precoated with histone H3 substrate, the antibody against methylated lysine residue of Histone H3, a secondary...
| Schlagworte: | WHSC1, Wolf-Hirschhorn Syndrome Candidate 1, MMSET, Multiple Myeloma SET Domain Containing Protein, NSD2, Nuclear SET... |
| Anwendung: | Enzyme kinetics, HTS |
| Spezies-Reaktivität: | human |
1.101,00 €