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Zu "K11348" wurden 19 Artikel gefunden!
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Artikelnummer: Cay17663-1
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1, aka BR140 or Peregrin, is important for maintaining Hox gene expression and the development of multiple...
Schlagworte: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
Anwendung: | BRPF1 bromodomain probe, tri-acetylated histone 4 binding inhibitor |
CAS | 900305-37-5 |
MW: | 380.4 D |
ab 60,00 €
Artikelnummer: Cay20985-5
GSK6853 is a chemical probe for the bromodomain of BRPF1 that displays a TR-FRET pIC50 value of 8.1 and a BROMOscan pKd value of 9.5. It exhibits >1,600-fold selectivity for BRPF1 over all other bromodomains in a BROMOscan assay and shows cellular target engagement with a pIC50 value of 7.7 in a NanoBRET assay...
Schlagworte: | N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-benzamide |
Anwendung: | Peregrin inhibitor |
CAS | 1910124-24-1 |
MW: | 409.5 D |
ab 43,00 €
Artikelnummer: Cay17662-1
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple...
Schlagworte: | 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide |
Anwendung: | BRPF bromodomain inhibitor |
CAS | 1883548-89-7 |
MW: | 383.4 D |
ab 43,00 €
Artikelnummer: Cay18123-5
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple...
Schlagworte: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide |
Anwendung: | Cell-permeable BRPF1 bromodomain inhibitor |
CAS | 901245-65-6 |
MW: | 394.5 D |
ab 43,00 €
Artikelnummer: Cay17124-1
OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1...
Schlagworte: | 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide |
Anwendung: | BRPF probe |
CAS | 919973-83-4 |
MW: | 440.3 D |
ab 66,00 €
Artikelnummer: Cay28293-5
NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid...
Schlagworte: | 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-benzenesulfonamide |
Anwendung: | Peregrin/BRPF1 inhibitor |
CAS | 1884640-99-6 |
MW: | 353.4 D |
ab 43,00 €
Artikelnummer: BPS-31112
Human Bromodomain and PHD finger containing 1, or BRPF1, amino-acids 627 ? 746 (GenBank Accession No. NM_001003694) with N-terminal HIS-tag, MW = 15.1 kDa, expressed in an E. coli expression system.
Schlagworte: | Peregrin, Protein Br140, Bromodomain and PHD finger-containing protein 1, |
Anwendung: | BRD binding assays, inhibitor screening, selectivity profiling |
Exprimiert in: | E.coli |
Ursprungsart: | human |
MW: | 14.3 kD |
452,00 €
Artikelnummer: SYN-3047-M001
Potent and selective BRPF1 bromodomain inhibitor, with an IC50 of 80nM. PFI-4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. PFI-4 specifically binds to the bromodomain of BRPF1 (Kd = 13nM), inhibiting binding to tri-acetylated histone 4 (residues...
Schlagworte: | N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
Anwendung: | Potent,selective BRPF1 bromodomain inhibitor |
CAS | 900305-37-5 |
MW: | 380.5 D |
ab 66,00 €
Artikelnummer: G-CAB17012.100
Protein function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone...
Schlagworte: | Anti-Peregrin, Anti-Protein Br140, Anti-Bromodomain and PHD finger-containing protein 1, BRPF1 Rabbit pAb |
Anwendung: | WB, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 352,00 €
Artikelnummer: ATA-HPA003359.100
Protein function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone...
Schlagworte: | Anti-Peregrin, Anti-Protein Br140, Anti-Bromodomain and PHD finger-containing protein 1 |
Anwendung: | IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 335,00 €
Artikelnummer: E-AB-91679.120
This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and...
Schlagworte: | Peregrin, Protein Br140, Bromodomain and PHD finger-containing protein 1, BRPF1 Polyclonal Antibody |
Anwendung: | WB, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 198,00 €
Artikelnummer: BPS-82066
GSK-5959 exhibits >100-fold selectivity for BRPF1 (IC50 = 80 nM) over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3, which is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
Schlagworte: | GSK5959, GSK 5959, |
Anwendung: | BRPF1 (Peregrin) bromodomain inhibitor |
CAS | 901245-65-6 |
MW: | 394,5 D |
696,00 €