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PFI-4
PFI-4

Artikelnummer: Cay17663-1

The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1, aka BR140 or Peregrin, is important for maintaining Hox gene expression and the development of multiple...
Schlagworte: N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide
Anwendung: BRPF1 bromodomain probe, tri-acetylated histone 4 binding inhibitor
CAS 900305-37-5
MW: 380.4 D
ab 60,00 €
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GSK6853
GSK6853

Artikelnummer: Cay20985-5

GSK6853 is a chemical probe for the bromodomain of BRPF1 that displays a TR-FRET pIC50 value of 8.1 and a BROMOscan pKd value of 9.5. It exhibits >1,600-fold selectivity for BRPF1 over all other bromodomains in a BROMOscan assay and shows cellular target engagement with a pIC50 value of 7.7 in a NanoBRET assay...
Schlagworte: N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-benzamide
Anwendung: Peregrin inhibitor
CAS 1910124-24-1
MW: 409.5 D
ab 43,00 €
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NI-57
NI-57

Artikelnummer: Cay17662-1

The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple...
Schlagworte: 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide
Anwendung: BRPF bromodomain inhibitor
CAS 1883548-89-7
MW: 383.4 D
ab 43,00 €
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GSK5959
GSK5959

Artikelnummer: Cay18123-5

The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple...
Schlagworte: N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide
Anwendung: Cell-permeable BRPF1 bromodomain inhibitor
CAS 901245-65-6
MW: 394.5 D
ab 43,00 €
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OF-1
OF-1

Artikelnummer: Cay17124-1

OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1...
Schlagworte: 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide
Anwendung: BRPF probe
CAS 919973-83-4
MW: 440.3 D
ab 66,00 €
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NI-42
NI-42

Artikelnummer: Cay28293-5

NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid...
Schlagworte: 4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-benzenesulfonamide
Anwendung: Peregrin/BRPF1 inhibitor
CAS 1884640-99-6
MW: 353.4 D
ab 43,00 €
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BRPF1 (627-746), human recombinant protein, N-terminal His tag
BRPF1 (627-746), human recombinant protein, N-terminal...

Artikelnummer: BPS-31112

Human Bromodomain and PHD finger containing 1, or BRPF1, amino-acids 627 ? 746 (GenBank Accession No. NM_001003694) with N-terminal HIS-tag, MW = 15.1 kDa, expressed in an E. coli expression system.
Schlagworte: Peregrin, Protein Br140, Bromodomain and PHD finger-containing protein 1,
Anwendung: BRD binding assays, inhibitor screening, selectivity profiling
Exprimiert in: E.coli
Ursprungsart: human
MW: 14.3 kD
452,00 €
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PFI-4
PFI-4

Artikelnummer: SYN-3047-M001

Potent and selective BRPF1 bromodomain inhibitor, with an IC50 of 80nM. PFI-4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. PFI-4 specifically binds to the bromodomain of BRPF1 (Kd = 13nM), inhibiting binding to tri-acetylated histone 4 (residues...
Schlagworte: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide
Anwendung: Potent,selective BRPF1 bromodomain inhibitor
CAS 900305-37-5
MW: 380.5 D
ab 66,00 €
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Anti-BRPF1
Anti-BRPF1

Artikelnummer: G-CAB17012.100

Protein function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone...
Schlagworte: Anti-Peregrin, Anti-Protein Br140, Anti-Bromodomain and PHD finger-containing protein 1, BRPF1 Rabbit pAb
Anwendung: WB, IF
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
ab 352,00 €
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Anti-BRPF1
Anti-BRPF1

Artikelnummer: ATA-HPA003359.100

Protein function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone...
Schlagworte: Anti-Peregrin, Anti-Protein Br140, Anti-Bromodomain and PHD finger-containing protein 1
Anwendung: IHC
Wirt: Rabbit
Spezies-Reaktivität: human
ab 335,00 €
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Anti-BRPF1
Anti-BRPF1

Artikelnummer: E-AB-91679.120

This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and...
Schlagworte: Peregrin, Protein Br140, Bromodomain and PHD finger-containing protein 1, BRPF1 Polyclonal Antibody
Anwendung: WB, IF
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
ab 198,00 €
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GSK-5959
GSK-5959

Artikelnummer: BPS-82066

GSK-5959 exhibits >100-fold selectivity for BRPF1 (IC50 = 80 nM) over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3, which is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
Schlagworte: GSK5959, GSK 5959,
Anwendung: BRPF1 (Peregrin) bromodomain inhibitor
CAS 901245-65-6
MW: 394,5 D
696,00 €
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