Zu "K11219" wurden 62 Artikel gefunden!
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NEU
TC JL 37
Artikelnummer: Cay43110-1
TC JL 37 is an inhibitor of tyrosine kinase 2 (TYK2, Ki = 1. nM). It inhibits IL-12-induced phosphorylation of STAT4 in cells and IL-12- and IL-18-induced IFN-gamma production in isolated human peripheral blood mononuclear cells (PBMCs, EC50s = 224 and 168 nM, respectively). TC JL 37 (10-100 mg/kg) inhibits IL-12-...
| Schlagworte: | 2-chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]-benzamide |
| Anwendung: | TYK2 inhibitor |
| CAS | 1258294-34-6 |
| MW: | 376.75 D |
ab 39,00 €
NEU
RO495
Artikelnummer: Cay43139-1
RO495 is a tyrosine kinase 2 (TYK2) inhibitor.. Solulibility: DMSO: Soluble: = 10 mg/ml: Ethanol: Sparingly soluble: 1-10 mg/ml.
| Schlagworte: | N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro-benzamide |
| Anwendung: | TYK2 inhibitor |
| CAS | 1258296-60-4 |
| MW: | 389.24 D |
ab 81,00 €
TYK2 JH2 Domain (human, recombinant, aa 575-869)
Artikelnummer: Cay42270-20
Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling. It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-homology 2 (SH2) domain, an autoinhibitory and catalytically inactive...
| Schlagworte: | TYK2, Non-receptor tyrosine-protein kinase TYK2, Non-receptor tyrosine-protein kinase TYK2 |
| Anwendung: | Active enzyme |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
513,00 €
SAR-20347
Artikelnummer: TGM-T4210-100mg
Description: SAR-20347 is an inhibitor of TYK2 and JAK1/2/3, with IC50 values of 0.6 nM, 23 nM, 26 nM, and 41 nM, respectively. Target: Tyrosine Kinases, JAK. Smiles: NC(=O)c1nc(oc1Nc1ccc(cc1)C(=O)N1CCOCC1)-c1c(F)cccc1Cl. References: Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced...
| Schlagworte: | SAR20347 |
| Anwendung: | JAK family kinase inhibitor |
| CAS | 1450881-55-6 |
| MW: | 444.84 D |
ab 31,00 €
TYK2 Protein, Human, Recombinant (E. coli, His)
Artikelnummer: TGM-TMPH-01777-100ug
Description: TYK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.9 kDa and the accession number is P29597.
| Schlagworte: | TYK2, Non-receptor tyrosine-protein kinase TYK2 |
| MW: | 37.9 kD |
ab 281,00 €
TYK2 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01778-100ug
Description: TYK2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 34.4 kDa and the accession number is P29597.
| Schlagworte: | Non-receptor tyrosine-protein kinase TYK2, TYK2 |
| MW: | 34.4 kD |
ab 491,00 €
NDI-034858
Artikelnummer: TGM-T62902-100mg
Description: NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23. Target: IL Receptor, Tyrosine Kinases. Smiles:...
| Schlagworte: | NDI-03485, TAK-279 |
| Anwendung: | TYK2 inhibitor |
| CAS | 2272904-53-5 |
| MW: | 460.49 D |
ab 261,00 €
TYK2 (Tyrosine Kinase 2) Assay Kit
Artikelnummer: BPS-79527
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that play an important role in cytokine-mediated signaling. This family includes four protein kinases, Jak1, Jak2, Jak3 and Tyk2. Various studies have suggested that regulation of Jak activity should be a promising approach to combat...
| Schlagworte: | TYK2, EC=2.7.10.2, Non-receptor tyrosine-protein kinase TYK2 |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
886,00 €
Deucravacitinib
Artikelnummer: TGM-T14687-1mg
Description: Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated...
| Schlagworte: | BMS-986165 |
| Anwendung: | Targets non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] (TYK2) |
| CAS | 1609392-27-9 |
| MW: | 425.46 D |
ab 63,00 €
PF-06826647
Artikelnummer: Cay37577-1
PF-06826647 is an inhibitor of tyrosine kinase 2 (TYK2, IC50 = 15 nM). It is selective for TYK2 over JAK1, JAK2, and JAK3 (IC50s = 383, 74, and >10,000 nM, respectively). PF-06826647 inhibits IL-12-induced phosphorylation of STAT4 in isolated human whole blood (IC50 = 14 nM). In vivo, PF-06826647 (3-30 mg/kg, p.o.)...
| Schlagworte: | Ropsacitinib, TYK2 Inhibitor 8, TYK2-IN-8,... |
| Anwendung: | TYK2 inhibitor |
| CAS | 2127109-84-4 |
| MW: | 383.4 D |
ab 81,00 €
Bayer 18
Artikelnummer: Cay41124-1
Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM). It is selective for TYK2 over JAK2, cyclin-dependent kinase 2 (Cdk2), and VEGFR2 (IC50s = 2,000, 1,790, and 3,520 nM, respectively).Formal Name:...
| Schlagworte: | N-(1,1-dimethylethyl)-N'-[3-[[5-fluoro-4-[(2-hydroxy-1,1-dimethylethyl)amino]-2-pyrimidinyl]amino]phenyl]-urea |
| Anwendung: | TYK2 inhibitor |
| CAS | 1251752-12-1 |
| MW: | 390.5 D |
ab 126,00 €
Ropsacitinib
Artikelnummer: TGM-T13237L-10mg
Description: Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM). Target: Tyrosine Kinases. Smiles: C(C#N)[C@@]1(C[C@H](C#N)C1)N2C=C(C=N2)C=3C=4N(C=C(N3)C=5C=NN(C)C5)N=CC4. References: Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine...
| Schlagworte: | Tyk2-IN-8, PF-06826647 |
| Anwendung: | Targets non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] (TYK2) |
| CAS | 2127109-84-4 |
| MW: | 383.41 D |
ab 242,00 €