Zu "K11218" wurden 92 Artikel gefunden!
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COVID-19 Forschung
Tofacitinib
Artikelnummer: AG-CR1-3625-M005
Off-white to pale yellow solid. Soluble in DMSO or ethanol. Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity, Immunosuppressive and anti-inflammatory agent, Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional...
| Schlagworte: | CP-690550, Xeljanz, Tasocitinib |
| Anwendung: | Cell-permeable JAK3 inhibitor |
| CAS | 477600-75-2 |
| MW: | 312,4 D |
ab 77,00 €
Tofacitinib (citrate)
Artikelnummer: Cay11598-5
Tofacitinib is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively). It is selective for JAK1-3 over ROCK2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits...
| Schlagworte: | Tofacitinib citrate,... |
| Anwendung: | JAK inhibitor |
| CAS | 540737-29-9 |
| MW: | 504.5 D |
ab 102,00 €
VX-509
Artikelnummer: Cay19513-1
VX-509 is a selective inhibitor of Janus kinase 3 (JAK3) with a Ki value of 2.5 nM in enzyme assays and an IC50 value of 50-170 nM in cellular assays dependent on JAK3 activity with no measurable activity against other JAK isotypes. At 10-100 mg/kg, it has been shown to dose dependently reduce proinflammatory...
| Schlagworte: | Decernotinib, VRT-831509,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 944842-54-0 |
| MW: | 392.4 D |
ab 54,00 €
WHI-P131
Artikelnummer: Cay10011246-10
Janus kinase 3 (JAK3) is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STATs). JAK3 is abundantly expressed in normal lymphoid cells as well as human...
| Schlagworte: | Janex 1, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Anwendung: | JAK3 inhibitor |
| CAS | 202475-60-3 |
| MW: | 297.3 D |
ab 48,00 €
ZM 39923 (hydrochloride)
Artikelnummer: Cay16729-1
ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively). In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the...
| Schlagworte: | JAK3 Inhibitor IV, Janus-Associated Kinase 3 Inhibitor IV,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 1021868-92-7 |
| MW: | 367.9 D |
ab 67,00 €
FM-381
Artikelnummer: Cay23204-1
FM-381 is a potent inhibitor of JAK3 (IC50 = 127 pM). It is 400-, 2,700-, and 3,600-fold selective for JAK3 over JAK1, JAK2, and TYK3 and only inhibits 11 kinases by less than 50 percent in a panel of 410 kinases when used at a concentration of 500 nM. FM-381 (1 µM) blocks JAK3-dependent STAT5 phosphorylation but...
| Schlagworte: | (E)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide |
| Anwendung: | Potent JAK3 inhibitor |
| MW: | 428.5 D |
ab 67,00 €
Decernotinib
Artikelnummer: LKT-D364086.5
JAK3 inhibitor.
| Schlagworte: | VX-509, VRT-831509, Adelitinib |
| Anwendung: | JAK3 inhibitor |
| CAS | 944842-54-0 |
| MW: | 392.39 D |
ab 123,00 €
Tofacitinib . citrate
Artikelnummer: AG-CR1-3732-M005
White to off-white solid. Soluble in DMSO (20mg/ml) or DMF (5mg/ml). Slightly soluble in ethanol or water. Chemical. CAS: 540737-29-9. Formula: C16H20N6O . C6H8O7. MW: 312.4 . 192.1. Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory...
| Schlagworte: | CP-690550, Xeljanz, Tasocitinib |
| Anwendung: | JAK3 inhibitor |
| CAS | 540737-29-9 |
| MW: | 504,5 D |
ab 55,00 €
TCS 21311
Artikelnummer: Cay30063-5
TCS 21311 is an inhibitor of JAK3 (IC50 = 8 nM in an enzyme assay). It is selective for JAK3 over JAK1, JAK2, and tyrosine kinase 2 (TYK2, IC50s = 1,017, 2,550, and 8,055 nM, respectively) but does inhibit glycogen synthase kinase 3beta (GSK-3beta), PKCalpha, and PKCtheta (IC50s = 13, 68, and 3 nM, respectively)....
| Schlagworte: | NIBR3049,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 1260181-14-3 |
| MW: | 526.5 D |
ab 85,00 €
PF-06651600
Artikelnummer: Cay21054-10
PF-06651600 is a covalent inhibitor of JAK3 (IC50 = 33.1 nM). It is selective for JAK3 over JAK1, JAK2, and tyrosine kinase 2 (TYK2, IC50s = >10,000 for all) and a panel of 304 other kinases at 1 µM. PF-06651600 inhibits STAT5, STAT6, and STAT3 phosphorylation induced by IL-2, IL-4, or IL-21, respectively, in...
| Schlagworte: | Ritlecitinib, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one |
| Anwendung: | Covalent JAK3 inhibitor |
| CAS | 1792180-81-4 |
| MW: | 285.3 D |
ab 123,00 €
JAK3-IN-6
Artikelnummer: TGM-T5492-2mg
Description: JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM. Target: JAK. Smiles: CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(C)=C)c3)c12. References: Elwood F, et al. Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor. J...
| Anwendung: | JAK3 inhibitor |
| CAS | 1443235-95-7 |
| MW: | 350.37 D |
ab 33,00 €
MS-1020
Artikelnummer: AG-CR1-3501-M001
Selective JAK3 inhibitor, Blocks STAT signaling, Inducer of apoptosis via down-regulation of anti-apoptotic gene expression.
| Schlagworte: | 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide |
| Anwendung: | JAK3 inhibitor |
| MW: | 346,4 D |
72,00 €