Zu "K10808" wurden 76 Artikel gefunden!
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Clofarabine
Artikelnummer: Cay14125-50
Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-alpha (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial...
| Schlagworte: | Clolar, Evoltra, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine |
| Anwendung: | Ribonucleotide reductase and DNA polymerase-alpha Inhibitor |
| CAS | 123318-82-1 |
| MW: | 303.7 D |
ab 57,00 €
3-AP
Artikelnummer: Cay15419-1
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 µM...
| Schlagworte: | 3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone, NSC 663249, Triapine(TM),... |
| Anwendung: | Ribonucleotide reductase inhibitor |
| CAS | 143621-35-6 |
| MW: | 195.2 D |
ab 49,00 €
Clofarabine
Artikelnummer: LKT-C4646.10
Nucleoside (adenosine) analog, DNA chain terminator, ribonucleotide reductase and DNA polymerase inhibitor, A1/2/3 adenosine modulator.
| Schlagworte: | (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol |
| Anwendung: | Ribonucleotide reductase inhibitor |
| CAS | 123318-82-1 |
| MW: | 303.68 D |
ab 249,00 €
Human RRM2 / Ribonucleoside-diphosphate reductase subunit...
Artikelnummer: G-HUFI01125.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-RRM2B/p53R2 (Ribonucleoside-diphosphate reductase...
Artikelnummer: 600-401-B67
Protein function: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with...
| Schlagworte: | Anti-p53R2, Anti-P53R2, Anti-RRM2B, EC=1.17.4.1, Anti-TP53-inducible ribonucleotide reductase M2 B,... |
| Anwendung: | ELISA, IHC, IFM, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 180,00 €
Anti-p53R2
Artikelnummer: 600-401-DJ1
Anti-p53R2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with p53R2 from other sources has not been determined. Protein function: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies...
| Schlagworte: | Anti-RRM2B, Anti-P53R2, Anti-p53R2, EC=1.17.4.1, Anti-TP53-inducible ribonucleotide reductase M2 B,... |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
Anti-p53R2
Artikelnummer: NSJ-R31164
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Ribonucleotide Reductase, M2 B, also known as P53R2, is an enzyme that in humans is encoded by the RRM2B gene. Tanaka et al.(2000) mapped the gene to chromosome 8q23.1 by fluorescence in situ hybridization. Tanaka et al.(2000) found that expression of p53R2, but...
| Schlagworte: | Anti-RRM2B, Anti-p53R2, Anti-P53R2, EC=1.17.4.1, Anti-TP53-inducible ribonucleotide reductase M2 B,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-RRM2
Artikelnummer: NSJ-R32063
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene. It is mapped to 2p25-p24. This gene encodes one of two non-identical subunits for ribonucleotide...
| Schlagworte: | Anti-RR2, Anti-RRM2, EC=1.17.4.1, Anti-Ribonucleotide reductase small chain, Anti-Ribonucleotide reductase small subunit,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-RRM2
Artikelnummer: ARG59083.100
Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. [The UniProt Consortium]
| Schlagworte: | Anti-RR2, Anti-RRM2, EC=1.17.4.1, Anti-Ribonucleotide reductase small chain, Anti-Ribonucleotide reductase small subunit,... |
| Anwendung: | ICC, IF, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
707,00 €
Anti-RRM2
Artikelnummer: ARG59132.50
Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. [The UniProt Consortium]
| Schlagworte: | Anti-RR2, Anti-RRM2, EC=1.17.4.1, Anti-Ribonucleotide reductase small chain, Anti-Ribonucleotide reductase small subunit,... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
551,00 €
Anti-RRM2
Artikelnummer: ARG59141.100
Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. [The UniProt Consortium]
| Schlagworte: | Anti-RR2, Anti-RRM2, EC=1.17.4.1, Anti-Ribonucleotide reductase small chain, Anti-Ribonucleotide reductase small subunit,... |
| Anwendung: | ICC, IF, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
658,00 €
Anti-RRM2B
Artikelnummer: ATA-HPA028812.100
Protein function: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with...
| Schlagworte: | Anti-P53R2, Anti-RRM2B, Anti-p53R2, EC=1.17.4.1, Anti-TP53-inducible ribonucleotide reductase M2 B,... |
| Anwendung: | ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 369,00 €