Zu "K10686" wurden 29 Artikel gefunden!
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MLN4924
Artikelnummer: Cay15217-1
NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates with roles relevant to cellular processes important for cancer cell survival. Neddylation of CRLs is initiated...
| Schlagworte: | Pevonedistat, sulfamic acid,... |
| Anwendung: | Adenosine 5'-monophosphate analog, NAE inhibitor |
| CAS | 905579-51-3 |
| MW: | 443.5 D |
ab 66,00 €
NEDD8 Inhibitor M22
Artikelnummer: Cay37756-1
NEDD8 inhibitor M22 is an inhibitor of NEDD8-activating enzyme (NAE). It inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay using recombinant human NAE in a concentration-dependent manner. NEDD8 inhibitor M22 selectively inhibits NEDDylation over SUMOylation and ubiquitination in...
| Schlagworte: | NAE-IN-M22, NEDD8-activating Enzyme Inhibitor M22, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine |
| Anwendung: | NEDD8-activating enzyme inhibitor |
| CAS | 864420-54-2 |
| MW: | 363.3 D |
ab 90,00 €
MLN4924 Solution
Artikelnummer: AG-CS1-0103-M001
Liquid. Potent, selective and cell-permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE), By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis.
| Schlagworte: | Pevonedistat, Nedd8 E1 Activating Enzyme Inhibitor |
| Anwendung: | Potent, selective, cell-permeable Nedd8 E1 activating enzyme inhibitor |
| CAS | 905579-51-3 |
| MW: | 443,5 D |
264,00 €
Human UBA3 / NEDD8 E1 ELISA Kit
Artikelnummer: G-HUFI00894.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Anti-UBE1C / UBA3
Artikelnummer: NSJ-R32284
0.5mg/ml if reconstituted with 0.2ml sterile DI water. NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, EC=6.3.2.-, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Anti-UBA3
Artikelnummer: ARG59226.50
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, EC=6.2.1.-, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3,... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
520,00 €
Anti-UBA3
Artikelnummer: G-CAB15119.100
IF 1:50 - 1:200. Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, EC=6.2.1.-, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3,... |
| Anwendung: | IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 352,00 €
Anti-UBA3
Artikelnummer: G-CAB7504.100
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 352,00 €
Anti-UBA3
Artikelnummer: ATA-HPA034873.100
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3, Anti-Ubiquitin-activating... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €
Anti-UBA3
Artikelnummer: ATA-HPA034874.100
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3, Anti-Ubiquitin-activating... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
446,00 €
Anti-UBA3
Artikelnummer: ATA-HPA065335.100
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3, Anti-Ubiquitin-activating... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 335,00 €
Anti-UBA3
Artikelnummer: ELK-ES12458.100
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s....
| Schlagworte: | Anti-UBA3, Anti-UBE1C, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3, Anti-Ubiquitin-activating... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 169,00 €