Zu "K10686" wurden 33 Artikel gefunden!
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MLN4924
Artikelnummer: Cay15217-1
NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates with roles relevant to cellular processes important for cancer cell survival. Neddylation of CRLs is initiated...
| Schlagworte: | Pevonedistat, sulfamic acid,... |
| Anwendung: | Adenosine 5'-monophosphate analog, NAE inhibitor |
| CAS | 905579-51-3 |
| MW: | 443.5 D |
ab 79,00 €
MLN4924 Solution
Artikelnummer: AG-CS1-0103-M001
Liquid. Potent, selective and cell-permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE), By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis.
| Schlagworte: | Pevonedistat, Nedd8 E1 Activating Enzyme Inhibitor |
| Anwendung: | Potent, selective, cell-permeable Nedd8 E1 activating enzyme inhibitor |
| CAS | 905579-51-3 |
| MW: | 443,5 D |
264,00 €
Human UBA3 / NEDD8 E1 ELISA Kit
Artikelnummer: G-HUFI00894.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-UBE1C / UBA3
Artikelnummer: NSJ-R32284
0.5mg/ml if reconstituted with 0.2ml sterile DI water. NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, EC=6.3.2.-, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3,... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-UBA3
Artikelnummer: ARG59226.50
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, EC=6.2.1.-, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3,... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
551,00 €
Anti-UBA3
Artikelnummer: ATA-HPA034873.100
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3, Anti-Ubiquitin-activating... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 246,00 €
Anti-UBA3
Artikelnummer: ATA-HPA034874.100
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3, Anti-Ubiquitin-activating... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
491,00 €
Anti-UBA3
Artikelnummer: ATA-HPA065335.100
Protein function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the...
| Schlagworte: | Anti-UBA3, Anti-UBE1C, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3, Anti-Ubiquitin-activating... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 369,00 €
NEU
![Anti-UBA3 [R05-6C8] Monoclonal Antibody](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg "Anti-UBA3 [R05-6C8] Monoclonal Antibody")
Anti-UBA3 [R05-6C8] Monoclonal Antibody
Artikelnummer: G-AGMB00516.100
UBA3 Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic...
| Schlagworte: | Anti-UBA3, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme E1C, Anti-Ubiquitin-like modifier-activating... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 134,00 €
UBE1C, Recombinant, Human, aa1-463, His-Tag...
Artikelnummer: 045470.100
UBA3, also known as NEDD8-activating enzyme E1 catalytic subunit, is the catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester...
| Schlagworte: | UBA3, UBE1C, EC=6.3.2.-, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme 3, Ubiquitin-activating enzyme E1C,... |
| Ursprungsart: | human |
ab 636,00 €
NEDD8 Inhibitor M22
Artikelnummer: Cay37756-1
NEDD8 inhibitor M22 is an inhibitor of NEDD8-activating enzyme (NAE). It inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay using recombinant human NAE in a concentration-dependent manner. NEDD8 inhibitor M22 selectively inhibits NEDDylation over SUMOylation and ubiquitination in...
| Schlagworte: | NAE-IN-M22, NEDD8-activating Enzyme Inhibitor M22, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine |
| Anwendung: | NEDD8-activating enzyme inhibitor |
| CAS | 864420-54-2 |
| MW: | 363.3 D |
ab 100,00 €
Anti-Zebrafish Uba3 / Ube1c / Nedd8 activating enzyme E1...
Artikelnummer: NSJ-RZ1142
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Predicted to enable NEDD8 activating enzyme activity. Predicted to be involved in protein neddylation. Predicted to be active in cytoplasm and nucleus. Is expressed in inner ear. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). Protein...
| Schlagworte: | Anti-uba3, Anti-ube1c, EC=6.2.1.64, Anti-NEDD8-activating enzyme E1C, Anti-Ubiquitin-activating enzyme 3,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | zebrafish |
948,00 €