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Zu "K10522" wurden 45 Artikel gefunden!
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Artikelnummer: ELK-ELK4816.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DIABLO. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DIABLO....
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
365,00 €
ab 328,50 €
Artikelnummer: Cay28632-500
SM-164 is a cell-permeable bivalent mimetic of Smac and an inhibitor of X-linked inhibitor of apoptosis (XIAP). It binds to BIR2 and BIR3 domain-containing XIAP with an IC50 value of 1.39 nM and interacts with both domains. SM-164 inhibits growth (IC50 = 1 nM), as well as activates caspase-3 and caspase-9, and...
Schlagworte: | (3S,3'S,6S,6'S,10aS,10'aS)-N,N'-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[deca... |
Anwendung: | Cell-permeable bivalent Smac mimetic, XIAP inhibitor |
CAS | 957135-43-2 |
MW: | 1121.4 D |
ab 125,00 €
Artikelnummer: Cay22420-5
LCL-161 is a small molecule Smac mimetic that inhibits multiple inhibitor of apoptosis (IAP) family proteins. As a single agent, LCL-161 inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis with IC50 values ranging from 0.5-4 µM. In vivo, LCL-161 enhances growth inhibition driven by PKC...
Schlagworte: | NVP-LCL161,... |
Anwendung: | DIABLO / SMAC mimetic, IAP inhibitor |
CAS | 1005342-46-0 |
MW: | 500.6 D |
ab 214,00 €
Artikelnummer: Cay19929-5
AT-406 is an orally bioavailable Smac/DIABLO mimetic and antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to XIAP, cIAP1, and cIAP2 proteins with Ki values of 66.4, 1.9, and 5.1 nM, respectively. It has been shown to inhibit cancer cell growth in various human cancer cell lines and to induce...
Schlagworte: | SM-406,... |
Anwendung: | Smac/DIABLO mimetic, IAPs antagonist |
CAS | 1071992-99-8 |
MW: | 561.7 D |
ab 43,00 €
Artikelnummer: LKT-L1044.1
SMAC mimetic, PXR agonist, IAP inhibitor.
Schlagworte: | LCL161 |
Anwendung: | DIABLO / SMAC mimetic, IAP inhibitor |
CAS | 1005342-46-0 |
MW: | 500.63 D |
ab 115,00 €
Artikelnummer: Cay28830-5
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 µM. BV6 (4 µM) induces...
Schlagworte: | 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide |
Anwendung: | IAP inhibitor, Bivalent Smac mimetic |
CAS | 1001600-56-1 |
MW: | 1205.6 D |
ab 60,00 €
Artikelnummer: Cay30932-1
AZD 5582 is a dimeric Smac mimetic and an inhibitor of the inhibitor of apoptosis (IAP) proteins. It binds to the BIR3 domains of IAP1, IAP2, and XIAP (IC50s = 15, 21, and 15 nM, respectively). It disrupts the protein-protein interaction between IAP1 and caspase-9 in vitro, as well as induces degradation of IAP1 in...
Schlagworte: | 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl... |
Anwendung: | Smac mimetic, IAP inhibitor |
CAS | 1258392-53-8 |
MW: | 1015.3 D |
ab 48,00 €
Artikelnummer: ABE-11-1043-100
Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-...
Schlagworte: | Anti-SMAC, Anti-Smac, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 134,00 €
Artikelnummer: ARG22319.50
Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-...
Schlagworte: | Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,... |
Anwendung: | ELISA, WB |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
520,00 €
Artikelnummer: ARG54330.50
Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-...
Schlagworte: | Anti-SMAC, Anti-Smac, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,... |
Anwendung: | WB, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
608,00 €
Artikelnummer: ARG54653.50
Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. [The UniProt Consortium]
Schlagworte: | Anti-Smac, Anti-Diablo, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI, Anti-Second... |
Anwendung: | ELISA, IHC, IP, WB, ICC, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
520,00 €
Artikelnummer: ARG57123.50
Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-...
Schlagworte: | Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,... |
Anwendung: | WB, ICC, IF, FC |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
488,00 €