Zu "K10522" wurden 52 Artikel gefunden!
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BV6
Artikelnummer: TGM-T6428-100mg
Description: BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. Target: IAP. Smiles: CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)NCCCCCCNC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C(c1ccccc1)c1ccccc1....
| Anwendung: | IAP inhibitor, bivalent Smac mimetic |
| CAS | 1001600-56-1 |
| MW: | 1205.57 D |
ab 45,00 €
Xevinapant
Artikelnummer: TGM-T6763-100mg
Description: Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. Target: IAP....
| Schlagworte: | Debio-1143, AT406, ARRY-334543, SM-406 |
| Anwendung: | Targets diablo (DIABLO, SMAC) |
| CAS | 1071992-99-8 |
| MW: | 561.71 D |
ab 37,00 €
SMAC Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-00924-100ug
Description: Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the...
| Schlagworte: | DFNA64, diablo, IAP-binding mitochondrial protein, SMAC |
| MW: | 22 kD |
355,00 €
Anti-DIABLO
Artikelnummer: CSB-PA592293.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DIABLO. Antigen Species: Human
| Schlagworte: | Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
Anti-DIABLO
Artikelnummer: CSB-PA966330.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DIABLO. Antigen Species: Human
| Schlagworte: | Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
LCL-161
Artikelnummer: Cay22420-5
LCL-161 is a small molecule Smac mimetic that inhibits multiple inhibitor of apoptosis (IAP) family proteins. As a single agent, LCL-161 inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis with IC50 values ranging from 0.5-4 µM. In vivo, LCL-161 enhances growth inhibition driven by PKC...
| Schlagworte: | NVP-LCL161,... |
| Anwendung: | DIABLO / SMAC mimetic, IAP inhibitor |
| CAS | 1005342-46-0 |
| MW: | 500.6 D |
ab 219,00 €
Diablo homolog, mitochondrial (DIABLO), human, recombinant
Artikelnummer: CSB-EP865113HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 56-239aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal GST-tagged. Target Protein Sequence: AVPIAQKSEP HSLSSEALMR RAVSLVTDST STFLSQTTYA LIEAITEYTK AVYTLTSLYR QYTSLLGKMN SEEEDEVWQV IIGARAEMTS KHQEYLKLET TWMTAVGLSE MAAEAAYQTG...
| Schlagworte: | SMAC, Smac, DIABLO, Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 47.4 kD |
ab 247,00 €
SM-164
Artikelnummer: Cay28632-500
SM-164 is a cell-permeable bivalent mimetic of Smac and an inhibitor of X-linked inhibitor of apoptosis (XIAP). It binds to BIR2 and BIR3 domain-containing XIAP with an IC50 value of 1.39 nM and interacts with both domains. SM-164 inhibits growth (IC50 = 1 nM), as well as activates caspase-3 and caspase-9, and...
| Schlagworte: | (3S,3'S,6S,6'S,10aS,10'aS)-N,N'-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[deca... |
| Anwendung: | Cell-permeable bivalent Smac mimetic, XIAP inhibitor |
| CAS | 957135-43-2 |
| MW: | 1121.4 D |
ab 135,00 €
AT-406
Artikelnummer: Cay19929-5
AT-406 is an orally bioavailable Smac/DIABLO mimetic and antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to XIAP, cIAP1, and cIAP2 proteins with Ki values of 66.4, 1.9, and 5.1 nM, respectively. It has been shown to inhibit cancer cell growth in various human cancer cell lines and to induce...
| Schlagworte: | SM-406,... |
| Anwendung: | Smac/DIABLO mimetic, IAPs antagonist |
| CAS | 1071992-99-8 |
| MW: | 561.7 D |
ab 44,00 €
BV6
Artikelnummer: Cay28830-5
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 µM. BV6 (4 µM) induces...
| Schlagworte: | 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide |
| Anwendung: | IAP inhibitor, bivalent Smac mimetic |
| CAS | 1001600-56-1 |
| MW: | 1205.6 D |
ab 61,00 €
LCL-161
Artikelnummer: LKT-L1044.1
SMAC mimetic, PXR agonist, IAP inhibitor.
| Schlagworte: | LCL161 |
| Anwendung: | DIABLO / SMAC mimetic, IAP inhibitor |
| CAS | 1005342-46-0 |
| MW: | 500.63 D |
ab 121,00 €
AZD 5582
Artikelnummer: Cay30932-1
AZD 5582 is a dimeric Smac mimetic and an inhibitor of the inhibitor of apoptosis (IAP) proteins. It binds to the BIR3 domains of IAP1, IAP2, and XIAP (IC50s = 15, 21, and 15 nM, respectively). It disrupts the protein-protein interaction between IAP1 and caspase-9 in vitro, as well as induces degradation of IAP1 in...
| Schlagworte: | 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl... |
| Anwendung: | Smac mimetic, IAP inhibitor |
| CAS | 1258392-53-8 |
| MW: | 1015.3 D |
ab 49,00 €