Zu "K10522" wurden 38 Artikel gefunden!

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NEU
AZD 5582
AZD 5582

Artikelnummer: Cay30932-1

AZD 5582 is a dimeric Smac mimetic and an inhibitor of the inhibitor of apoptosis (IAP) proteins. It binds to the BIR3 domains of IAP1, IAP2, and XIAP (IC50s = 15, 21, and 15 nM, respectively). It disrupts the protein-protein interaction between IAP1 and caspase-9 in vitro, as well as induces degradation of IAP1 in...
Schlagworte: 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl...
Anwendung: Smac mimetic, IAP inhibitor
CAS 1258392-53-8
MW: 1015.3 D
ab 35,00 €
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AT-406
AT-406

Artikelnummer: Cay19929-10

AT-406 is an orally bioavailable Smac/DIABLO mimetic and antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to XIAP, cIAP1, and cIAP2 proteins with Ki values of 66.4, 1.9, and 5.1 nM, respectively. It has been shown to inhibit cancer cell growth in various human cancer cell lines and to induce...
Schlagworte: SM-406,...
Anwendung: Smac/DIABLO mimetic, IAPs antagonist
CAS 1071992-99-8
MW: 561.7 D
ab 32,00 €
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LCL-161
LCL-161

Artikelnummer: Cay22420-5

LCL-161 is a small molecule Smac mimetic that inhibits multiple inhibitor of apoptosis (IAP) family proteins. As a single agent, LCL-161 inhibits growth of FLT3-ITD-expressing leukemia cells via induction of apoptosis with IC50 values ranging from 0.5-4 µM. In vivo, LCL-161 enhances growth inhibition driven by PKC...
Schlagworte: NVP-LCL161,...
Anwendung: DIABLO ?/? SMAC mimetic, IAP inhibitor
CAS 1005342-46-0
MW: 500.6 D
ab 163,00 €
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SM-164
SM-164

Artikelnummer: Cay28632-500

SM-164 is a cell-permeable bivalent mimetic of Smac and an inhibitor of X-linked inhibitor of apoptosis (XIAP). It binds to BIR2 and BIR3 domain-containing XIAP with an IC50 value of 1.39 nM and interacts with both domains. SM-164 inhibits growth (IC50 = 1 nM), as well as activates caspase-3 and caspase-9, and...
Schlagworte: (3S,3'S,6S,6'S,10aS,10'aS)-N,N'-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[deca...
Anwendung: Cell-permeable bivalent Smac mimetic, XIAP inhibitor
CAS 957135-43-2
MW: 1121.4 D
ab 174,00 €
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LCL-161
LCL-161

Artikelnummer: LKT-L1044.1

SMAC mimetic, PXR agonist, IAP inhibitor.
Schlagworte: LCL161
Anwendung: DIABLO / SMAC mimetic, IAP inhibitor
CAS 1005342-46-0
MW: 500.63 D
ab 87,00 €
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BV6
BV6

Artikelnummer: Cay28830-1

BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 µM. BV6 (4 µM) induces...
Schlagworte: 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide
Anwendung: IAP inhibitor, Bivalent Smac mimetic
CAS 1001600-56-1
MW: 1205.6 D
ab 44,00 €
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NEU
Diablo/SMAC, BioAssay(TM) ELISA Kit (Human) (Second Mitochondrial Activator of Caspase)
Diablo/SMAC, BioAssay(TM) ELISA Kit (Human) (Second...

Artikelnummer: 352821.96

Diablo homolog, mitochondrial, also known as second mitochondria-derived activator of caspases(SMAC), is a protein that in humans is encoded by the DIABLO gene(direct IAP binding protein with low pI). It is mapped to 12q24.31. DIABLO can bind mammalian IAP homolog A(MIHA, or API3) and can also interact with MIHB,...
Schlagworte: Smac, SMAC, DIABLO, Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived...
Anwendung: ELISA
Reaktivität: Human
704,00 €
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Anti-Smac/DIABLO
Anti-Smac/DIABLO

Artikelnummer: 100-401-244

Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-...
Schlagworte: Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,...
Anwendung: ELISA, WB, IP
Reaktivität: Human
493,00 €
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Anti-SMURF2
Anti-SMURF2

Artikelnummer: 600-401-ER7

Anti-SMURF2 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. SMURF2 antibody is human, mouse and rat reactive. SMURF2 is predicted to not cross-react with SMURF1. Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts...
Schlagworte: Anti-Smac, Anti-Diablo, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI, Anti-Second...
Anwendung: ELISA, IHC, IF, WB
Reaktivität: Human, Mouse, Rat
493,00 €
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Human Diablo - SMAC ELISA Kit
Human Diablo - SMAC ELISA Kit

Artikelnummer: KOA0503

Natural and recombinant human Diablo. There is no detectable cross-reactivity with other relevant proteins. Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the...
Schlagworte: SMAC, Smac, DIABLO, Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived...
Anwendung: ELISA
Reaktivität: Human
673,00 €
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Anti-Smac / Diablo, clone RM271 (recombinant antibody)
Anti-Smac / Diablo, clone RM271 (recombinant antibody)

Artikelnummer: NSJ-R20288-0.1ML

Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant Smac antibody reacts to human Smac (Diablo homolog, mitochondrial). Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of...
Schlagworte: Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,...
Anwendung: WB, IHC
Reaktivität: Human
580,00 €
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Anti-Smac / Diablo
Anti-Smac / Diablo

Artikelnummer: NSJ-R32332

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Diablo homolog (DIABLO), also referred to as second mitochondria-derived activator of caspases or SMAC, is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12. The encoded mitochondrial...
Schlagworte: Anti-SMAC, Anti-Smac, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI,...
Anwendung: WB, IHC (paraffin), ELISA
Reaktivität: Human, Mouse, Rat
503,00 €
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