Zu "K10456" wurden 54 Artikel gefunden!

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Human KEAP1 (Kelch Like ECH Associated Protein 1) ELISA Kit
Human KEAP1 (Kelch Like ECH Associated Protein 1) ELISA Kit

Artikelnummer: ELK-ELK7324.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human KEAP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human KEAP1. Next,...
Schlagworte: INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1
Anwendung: ELISA
Spezies-Reaktivität: human
365,00 € ab 328,50 €
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Mouse KEAP1 (Kelch Like ECH Associated Protein 1) ELISA Kit
Mouse KEAP1 (Kelch Like ECH Associated Protein 1) ELISA Kit

Artikelnummer: ELK-ELK8105.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse KEAP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse KEAP1. Next,...
Schlagworte: INrf2, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1
Anwendung: ELISA
Spezies-Reaktivität: mouse
365,00 € ab 328,50 €
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KEAP1-Nrf2 Inhibitor Screening Assay Kit
KEAP1-Nrf2 Inhibitor Screening Assay Kit

Artikelnummer: BPS-72020

The Keap1:Nrf2 Inhibitor Screening Assay Kit is designed for identification of inhibitors of Keap1:Nrf2 binding using fluorescence polarization. Using this kit, only one simple step on a microtiter plate is required for Keap1:Nrf2 inhibitor screening reactions. The Keap1 protein and fluorescently labeled Nrf2...
Schlagworte: INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1,
Anwendung: Inhibitor screening, drug discovery, HTS
Spezies-Reaktivität: human
1.403,00 €
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ML-385
ML-385

Artikelnummer: Cay21114-5

ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2, IC50 = 1.9 µM) that blocks downstream target gene expression. It substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs. ML-385 shows specificity and selectivity for NSCLC cells...
Schlagworte: N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
Anwendung: NRF2 inhibitor
CAS 846557-71-9
MW: 511.6 D
ab 125,00 €
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RTA 408
RTA 408

Artikelnummer: Cay17854-1

RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations =25 nM. In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-gamma. At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 =...
Schlagworte: Omaveloxolone, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-propanamide
Anwendung: Nrf2 activator, Keap1 binding
CAS 1474034-05-3
MW: 554.7 D
ab 82,00 €
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Keap1 (human, recombinant)
Keap1 (human, recombinant)

Artikelnummer: Cay32035-100

Kelch-like ECH-associated protein 1 (Keap1) is a substrate adapter protein in the Kelch-like (KLHL) family of proteins. It contains an N-terminal region, a BTB/POZ domain that facilitates protein binding and Keap1 dimerization, a central intervening region (IVR), a double glycine repeat (DGR)/Kelch repeat domain, a...
Schlagworte: Cytosolic Inhibitor of Nrf2, INRF2, Kelch-Like ECH-Associated Protein 1, KLHL19
Exprimiert in: Insect cells
Ursprungsart: human
MW: 97.37 kD
439,00 €
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KEAP1, His-tag
KEAP1, His-tag

Artikelnummer: BPS-70040-1

Human Keap1, also known as Kelch-like ECH-associated protein, INRF2, KIAA0132, and KLHL19, GenBank Accession No. NM_203500, a.a. 321-609 expressed in an E. coli cell expression system. MW = 32.6 kDa
Schlagworte: INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1,
Anwendung: Protein binding studies, small molecule screening
Exprimiert in: E.coli
Ursprungsart: human
MW: 32,6 kD
ab 752,00 €
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Anti-KEAP1
Anti-KEAP1

Artikelnummer: NSJ-R32225

0.5mg/ml if reconstituted with 0.2ml sterile DI water. KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 is a protein that in humans is encoded by the KEAP1 gene. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator...
Schlagworte: Anti-INRF2, Anti-INrf2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like...
Anwendung: WB
Wirt: Rabbit
Spezies-Reaktivität: human
755,00 €
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Anti-KEAP1
Anti-KEAP1

Artikelnummer: NSJ-R34041-100UG

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Kelch-like ECH-associated protein 1 Protein function: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination...
Schlagworte: Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like...
Anwendung: WB, IHC, ELISA (peptide)
Wirt: Goat
Spezies-Reaktivität: human, mouse
755,00 €
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2-HBA
2-HBA

Artikelnummer: Cay11879-10

Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective...
Schlagworte: Bis(2-hydroxybenzylidene)acetone, (1E,4E)-1,5-bis(2-hydroxyphenyl)-1,4-pentadien-3-one
Anwendung: Detoxification studies
CAS 131359-24-5
MW: 266.3 D
ab 88,00 €
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Anti-KEAP1, clone 297CT6.1.6
Anti-KEAP1, clone 297CT6.1.6

Artikelnummer: NSJ-F40314-0.08ML

In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by...
Schlagworte: Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like...
Anwendung: WB, ELISA
Wirt: Mouse
Spezies-Reaktivität: human
ab 326,00 €
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Anti-KEAP1
Anti-KEAP1

Artikelnummer: NSJ-F40464-0.08ML

In 1X PBS, pH 7.4, with 0.09% sodium azide. KEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of...
Schlagworte: Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like...
Anwendung: WB, IHC, ELISA
Wirt: Rabbit
Spezies-Reaktivität: human
ab 326,00 €
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