Zu "K10456" wurden 74 Artikel gefunden!
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Anti-KEAP1 / Kelch-like ECH-associated protein 1
Artikelnummer: NSJ-FY12106
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. KEAP1 antibody is designed to target Kelch-like ECH-associated protein 1, a critical regulator of cellular redox balance and stress response. The KEAP1 protein functions as a substrate adaptor protein within a Cullin 3-based E3 ubiquitin...
| Schlagworte: | Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like ECH-associated protein 1, KEAP1... |
| Anwendung: | WB, ICC, IF, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Anti-Recombinant Keap1, clone 9B10
Artikelnummer: E-AN300872L.100
KEAP1(kelch like ECH associated protein 1) Homo sapiens This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by...
| Schlagworte: | Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like ECH-associated protein 1,... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
ML-385
Artikelnummer: Cay21114-5
ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2, IC50 = 1.9 µM) that blocks downstream target gene expression. It substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs. ML-385 shows specificity and selectivity for NSCLC cells...
| Schlagworte: | N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide |
| Anwendung: | NRF2 inhibitor |
| CAS | 846557-71-9 |
| MW: | 511.6 D |
ab 139,00 €
KEAP1-Nrf2 Inhibitor Screening Assay Kit
Artikelnummer: BPS-72020
The Keap1:Nrf2 Inhibitor Screening Assay Kit is designed for identification of inhibitors of Keap1:Nrf2 binding using fluorescence polarization. Using this kit, only one simple step on a microtiter plate is required for Keap1:Nrf2 inhibitor screening reactions. The Keap1 protein and fluorescently labeled Nrf2...
| Schlagworte: | INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1, |
| Anwendung: | Inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.650,00 €
Keap1 (human, recombinant)
Artikelnummer: Cay32035-100
Kelch-like ECH-associated protein 1 (Keap1) is a substrate adapter protein in the Kelch-like (KLHL) family of proteins. It contains an N-terminal region, a BTB/POZ domain that facilitates protein binding and Keap1 dimerization, a central intervening region (IVR), a double glycine repeat (DGR)/Kelch repeat domain, a...
| Schlagworte: | Cytosolic Inhibitor of Nrf2, INRF2, Kelch-Like ECH-Associated Protein 1, KLHL19 |
| Exprimiert in: | Insect cells |
| Ursprungsart: | human |
| MW: | 97.37 kD |
487,00 €
KEAP1, His-tag
Artikelnummer: BPS-70040-1
Human Keap1, also known as Kelch-like ECH-associated protein, INRF2, KIAA0132, and KLHL19, GenBank Accession No. NM_203500, a.a. 321-609 expressed in an E. coli cell expression system. MW = 32.6 kDa
| Schlagworte: | INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1, |
| Anwendung: | Protein binding studies, small molecule screening |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 32,6 kD |
ab 767,00 €
RTA 408
Artikelnummer: Cay17854-1
RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations =25 nM. In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-gamma. At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 =...
| Schlagworte: | Omaveloxolone, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-propanamide |
| Anwendung: | Nrf2 activator, Keap1 binding |
| CAS | 1474034-05-3 |
| MW: | 554.7 D |
ab 44,00 €
ML385
Artikelnummer: TGM-T4360-5mg
Description: ML385 is an NRF2 inhibitor (IC50=1.9 µM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity. Target: Others, Ferroptosis, Nrf2. Smiles:...
| Anwendung: | NRF2 inhibitor |
| CAS | 846557-71-9 |
| MW: | 511.59 D |
ab 45,00 €
Kelch-like ECH-associated protein 1 (KEAP1), human,...
Artikelnummer: CSB-YP012147HU.100
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 1-624aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA...
| Schlagworte: | INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1, Recombinant Human... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 71.7 kD |
ab 347,00 €
Anti-KEAP1
Artikelnummer: NSJ-R32225
0.5mg/ml if reconstituted with 0.2ml sterile DI water. KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 is a protein that in humans is encoded by the KEAP1 gene. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator...
| Schlagworte: | Anti-INRF2, Anti-INrf2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Anti-KEAP1
Artikelnummer: NSJ-R34041-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Kelch-like ECH-associated protein 1 Protein function: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination...
| Schlagworte: | Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like... |
| Anwendung: | WB, IHC, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse |
836,00 €
2-HBA
Artikelnummer: Cay11879-10
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective...
| Schlagworte: | Bis(2-hydroxybenzylidene)acetone, (1E,4E)-1,5-bis(2-hydroxyphenyl)-1,4-pentadien-3-one |
| Anwendung: | Detoxification studies |
| CAS | 131359-24-5 |
| MW: | 266.3 D |
ab 97,00 €