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Zu "K10456" wurden 54 Artikel gefunden!
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Artikelnummer: ELK-ELK7324.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human KEAP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human KEAP1. Next,...
Schlagworte: | INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
365,00 €
ab 328,50 €
-10 %
Rabattaktion
Artikelnummer: ELK-ELK8105.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse KEAP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse KEAP1. Next,...
Schlagworte: | INrf2, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1 |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
365,00 €
ab 328,50 €
Artikelnummer: BPS-72020
The Keap1:Nrf2 Inhibitor Screening Assay Kit is designed for identification of inhibitors of Keap1:Nrf2 binding using fluorescence polarization. Using this kit, only one simple step on a microtiter plate is required for Keap1:Nrf2 inhibitor screening reactions. The Keap1 protein and fluorescently labeled Nrf2...
Schlagworte: | INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1, |
Anwendung: | Inhibitor screening, drug discovery, HTS |
Spezies-Reaktivität: | human |
1.403,00 €
Artikelnummer: Cay21114-5
ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2, IC50 = 1.9 µM) that blocks downstream target gene expression. It substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs. ML-385 shows specificity and selectivity for NSCLC cells...
Schlagworte: | N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide |
Anwendung: | NRF2 inhibitor |
CAS | 846557-71-9 |
MW: | 511.6 D |
ab 125,00 €
Artikelnummer: Cay17854-1
RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations =25 nM. In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-gamma. At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 =...
Schlagworte: | Omaveloxolone, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-propanamide |
Anwendung: | Nrf2 activator, Keap1 binding |
CAS | 1474034-05-3 |
MW: | 554.7 D |
ab 82,00 €
Artikelnummer: Cay32035-100
Kelch-like ECH-associated protein 1 (Keap1) is a substrate adapter protein in the Kelch-like (KLHL) family of proteins. It contains an N-terminal region, a BTB/POZ domain that facilitates protein binding and Keap1 dimerization, a central intervening region (IVR), a double glycine repeat (DGR)/Kelch repeat domain, a...
Schlagworte: | Cytosolic Inhibitor of Nrf2, INRF2, Kelch-Like ECH-Associated Protein 1, KLHL19 |
Exprimiert in: | Insect cells |
Ursprungsart: | human |
MW: | 97.37 kD |
439,00 €
Artikelnummer: BPS-70040-1
Human Keap1, also known as Kelch-like ECH-associated protein, INRF2, KIAA0132, and KLHL19, GenBank Accession No. NM_203500, a.a. 321-609 expressed in an E. coli cell expression system. MW = 32.6 kDa
Schlagworte: | INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1, |
Anwendung: | Protein binding studies, small molecule screening |
Exprimiert in: | E.coli |
Ursprungsart: | human |
MW: | 32,6 kD |
ab 752,00 €
Artikelnummer: NSJ-R32225
0.5mg/ml if reconstituted with 0.2ml sterile DI water. KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 is a protein that in humans is encoded by the KEAP1 gene. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator...
Schlagworte: | Anti-INRF2, Anti-INrf2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: NSJ-R34041-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Kelch-like ECH-associated protein 1 Protein function: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination...
Schlagworte: | Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like... |
Anwendung: | WB, IHC, ELISA (peptide) |
Wirt: | Goat |
Spezies-Reaktivität: | human, mouse |
755,00 €
Artikelnummer: Cay11879-10
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective...
Schlagworte: | Bis(2-hydroxybenzylidene)acetone, (1E,4E)-1,5-bis(2-hydroxyphenyl)-1,4-pentadien-3-one |
Anwendung: | Detoxification studies |
CAS | 131359-24-5 |
MW: | 266.3 D |
ab 88,00 €
Artikelnummer: NSJ-F40314-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by...
Schlagworte: | Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like... |
Anwendung: | WB, ELISA |
Wirt: | Mouse |
Spezies-Reaktivität: | human |
ab 326,00 €
Artikelnummer: NSJ-F40464-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. KEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of...
Schlagworte: | Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like... |
Anwendung: | WB, IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 326,00 €