Zu "K09568" wurden 99 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
NEU
Anti-FKBP12
Artikelnummer: ABS-KC-45190.100
Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): 97%. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%, Pig - 98%, Cynomolgus monkey - 100%. IHC Verification: -. WB Verification: succeed. IP...
| Schlagworte: | Anti-FKBP1A, Anti-Rotamase, Anti-Calstabin-1, Anti-Immunophilin FKBP12, Anti-FK506-binding protein 1A, Anti-12 kDa... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
NEU
Anti-FKBP12
Artikelnummer: ABS-KC-44599.100
Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): 97%. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%, Pig - 98%, Cynomolgus monkey - 100%. IHC Verification: -. WB Verification: succeed. IP...
| Schlagworte: | Anti-FKBP1A, Anti-Rotamase, Anti-Calstabin-1, Anti-Immunophilin FKBP12, Anti-FK506-binding protein 1A, Anti-12 kDa... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
NEU
Anti-FKBP12 (recombinant antibody)
Artikelnummer: ABS-RN-14819.100
Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): 97%. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%, Pig - 98%, Cynomolgus monkey - 100%. IHC Verification: -. WB Verification: succeed. IP...
| Schlagworte: | Anti-FKBP1A, Anti-Rotamase, Anti-Calstabin-1, Anti-Immunophilin FKBP12, Anti-FK506-binding protein 1A, Anti-12 kDa... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
FK-506
Artikelnummer: Cay10007965-5
FK-506 is a potent immunosuppressant in the same molecular class as cyclosporin A (Cay-12088) and rapamycin (Cay-13346). Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex then inhibits the activity of the...
| Schlagworte: | Tacrolimus,... |
| Anwendung: | Immunosuppressant |
| CAS | 104987-11-3 |
| MW: | 804 D |
ab 59,00 €
Tacrolimus
Artikelnummer: LKT-T0008.5
An immunosuppressant commonly used in transplant operations to prevent graft-versus-host disease.
| Schlagworte: | FK506, FK-506, fujimycin |
| Anwendung: | Immunomodulator |
| CAS | 104987-11-3 |
| MW: | 804,02 D |
ab 62,00 €
Ascomycin
Artikelnummer: Cay11309-5
Ascomycin, produced by the fermentation of S. hygroscopicus subsp. ascomyceticus, is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FK-506-binding protein 12 (FKBP12), an immunophilin that acts as the principal mediator of...
| Schlagworte: | Changchuanmycin, FK-520, FR900520, Immunomycin, L 683590,... |
| Anwendung: | Immunosuppressant |
| CAS | 104987-12-4 |
| MW: | 792 D |
ab 76,00 €
Shield-1
Artikelnummer: Cay37325-1
Shield-1 is a protein stabilizing ligand that prevents the proteosomal degradation of proteins fused to FK-506 binding protein 1A (FKBP12) containing a leucine-to-proline substitution at position 106 (FKBP12L106P). It displays specific binding for the destabilizing domain FKBP12L106P and does not interfere with...
| Schlagworte: | Shld1, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylic acid,... |
| Anwendung: | Protein stabilizing ligand |
| CAS | 914805-33-7 |
| MW: | 748.9 D |
ab 197,00 €
Anti-FKBP12/FKBP1A Monoclonal Antibody
Artikelnummer: E-AN200098P.100
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK503 and rapamycin. It interacts with several...
| Schlagworte: | FKBP1, FKBP1A, FKBP-1A, FKBP-12, Rotamase, 12 kDa FKBP, Calstabin-1, PPIase FKBP1A, Immunophilin FKBP12, FK506-binding... |
| Anwendung: | WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
Pimecrolimus
Artikelnummer: Cay13107-10
Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells. Moreover,...
| Schlagworte: | Elidel, SDZ-ASM 981,... |
| Anwendung: | Calcineurin inhibitor |
| CAS | 137071-32-0 |
| MW: | 810.5 D |
ab 42,00 €
FK-506
Artikelnummer: AG-CN2-0047-M025
Potent immunosuppressant (as cyclosporin A and rapamycin). Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Forms a complex with FK-506 binding protein 12 (FKBP12). Inhibits the activity of the calcium/calmodulin-dependent protein...
| Schlagworte: | Tacrolimus, Fujimycin |
| Anwendung: | Immunosuppressant |
| Wirt: | Streptomyces FCZ0311 |
| CAS | 104987-11-3 |
ab 17,00 €
Shield-1
Artikelnummer: TGM-T13884-1mg
Description: Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein. Target: Others. Smiles:...
| Anwendung: | Protein stabilizing ligand |
| CAS | 914805-33-7 |
| MW: | 748.9 D |
ab 153,00 €
Umirolimus
Artikelnummer: Cay23585-1
Umirolimus is a semisynthetic macrocyclic lactone and a derivative of rapamycin (Cay-13346) that has immunosuppressive and anti-inflammatory effects. It halts the cell cycle at the G1 phase through an IL-2/mTOR-mediated pathway and inhibits proliferation of human smooth muscle cells. In a porcine overstretch model,...
| Schlagworte: | 42-O-(2-ethoxyethyl)-rapamycin |
| Anwendung: | Immunosuppressant |
| CAS | 851536-75-9 |
| MW: | 986.3 D |
ab 180,00 €