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OTS964
OTS964

Artikelnummer: Cay17052-500

OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK, IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.
Schlagworte: 9-[4-[(1R)-2-(dimethylamino)-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one
Anwendung: PBK / TOPK inhibitor
CAS 1338542-14-5
MW: 392.5 D
ab 44,00 €
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HI TOPK 032
HI TOPK 032

Artikelnummer: Cay19815-5

HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 µM and providing complete inhibition at 5 µM. It also inhibits checkpoint kinase 1 (Chk1, IC50 = 9.6 µM). In addition, HI TOPK 032...
Schlagworte: N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
Anwendung: PBK inhibitor
CAS 487020-03-1
MW: 369.4 D
ab 34,00 €
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Anti-PBK
Anti-PBK

Artikelnummer: NSJ-R31723

0.5mg/ml if reconstituted with 0.2ml sterile DI water. PDZ binding kinase (PBK), also known as TOPK, is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. PBK can mediate cell growth through histone H3 modification. Evidence suggests that mitotic...
Schlagworte: Anti-PBK, Anti-SPK, Anti-CT84, Anti-TOPK, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen...
Anwendung: WB, IHC (paraffin)
Reaktivität: Human, Mouse, Rat
503,00 €
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Anti-PBK / TOPK
Anti-PBK / TOPK

Artikelnummer: ARG57467.100

Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Schlagworte: Anti-SPK, Anti-PBK, Anti-CT84, Anti-TOPK, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen...
Anwendung: WB
Reaktivität: Human, Rat
483,00 €
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Anti-PBK
Anti-PBK

Artikelnummer: E-AB-40065.120

PBK(PDZ-binding kinase) is also named as TOPK, CT84, Nori-3, SPK and belongs to the MAP kinase kinase subfamily. PBK may have a role in the regulation of cellular proliferation and progression of the cell cycle. It has a characteristic cdc2ycyclin B phosphorylation site(SyT-P-X-KyR) at its N terminus,which is...
Schlagworte: Anti-PBK, Anti-SPK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen...
Anwendung: WB, IHC
Reaktivität: Human, Mouse, Rat
ab 63,00 €
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Anti-PBK / TOPK
Anti-PBK / TOPK

Artikelnummer: ARG57886.100

Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Schlagworte: Anti-SPK, Anti-PBK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen...
Anwendung: WB
Reaktivität: Human
483,00 €
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OTS514
OTS514

Artikelnummer: Cay17053-1

OTS514 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK, IC50 = 2.6 nM), a serine-threonine kinase often overexpressed and transactivated in several types of cancer. OTS514 (10 nM) selectively inhibits growth of patient-derived acute myeloid leukemia (AML) cells over normal CD34+...
Schlagworte: 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one
Anwendung: TOPK inhibitor
CAS 1338540-63-8
MW: 364.5 D
ab 94,00 €
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Anti-PBK
Anti-PBK

Artikelnummer: A302-194A

Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Schlagworte: Anti-PBK, Anti-SPK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen...
Anwendung: IP
Reaktivität: Human
ab 125,00 €
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Anti-PBK
Anti-PBK

Artikelnummer: A302-195A

Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Schlagworte: Anti-PBK, Anti-SPK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen...
Anwendung: WB, IP, IHC
Reaktivität: Human
ab 125,00 €
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Anti-phospho-PBK / TOPK (Thr9)
Anti-phospho-PBK / TOPK (Thr9)

Artikelnummer: ARG57923.100

Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Schlagworte: Anti-phospho-PBK, Anti-phospho-SPK, Anti-phospho-CT84, Anti-phospho-TOPK, Anti-phospho-Nori-3, EC=2.7.12.2,...
Anwendung: WB
Reaktivität: Human
452,00 €
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Anti-PBK / TOPK
Anti-PBK / TOPK

Artikelnummer: ARG57922.100

Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization. [The UniProt Consortium]
Schlagworte: Anti-Pbk, Anti-Topk, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-T-LAK cell-originated protein kinase,...
Anwendung: IHC (paraffin), WB
Reaktivität: Human, Mouse, Rat
452,00 €
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OTS-964
OTS-964

Artikelnummer: LKT-O783720.100

inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK).
Anwendung: TOPK inhibitor
CAS 1338545-07-5
MW: 378.49 D
ab 136,00 €
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