Zu "K08860" wurden 62 Artikel gefunden!
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Mouse EIF2aK3 (Eukaryotic Translation Initiation Factor 2...
Artikelnummer: ELK-ELK7023.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse EIF2aK3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse EIF2aK3....
| Schlagworte: | Pek, Eif2ak3, Pancreatic eIF2-alpha kinase, PRKR-like endoplasmic reticulum kinase, Eukaryotic translation initiation... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Anti-phospho-PERK (Thr981)
Artikelnummer: ARG67075.100
Protein function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as...
| Schlagworte: | Anti-phospho-PEK, Anti-phospho-HsPEK, Anti-phospho-HsPEK, Anti-phospho-EIF2AK3, Anti-phospho-Pancreatic eIF2-alpha kinase,... |
| Anwendung: | ELISA, ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
624,00 €
trans-ISRIB
Artikelnummer: Cay16258-5
Phosphorylation of eIF2alpha by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric...
| Schlagworte: | N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) |
| Anwendung: | EIF2AK3 / PERK inhibitor |
| CAS | 1597403-47-8 |
| MW: | 451.3 D |
ab 109,00 €
GSK2656157
Artikelnummer: Cay17372-5
GSK2656157 is an inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK, IC50 = 0.9 nM). It is selective for PERK over a panel of additional kinases. GSK2656157 blocks both stress-induced PERK autophosphorylation and eIF2alpha substrate phosphorylation and decreases levels of ATF4 and CHOP in...
| Schlagworte: | 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-ethanone |
| Anwendung: | PERK inhibitor |
| CAS | 1337532-29-2 |
| MW: | 416.5 D |
ab 64,00 €
GSK2606414
Artikelnummer: Cay17376-1
GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC50 value of 0.4 nM. It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Because PERK mediates the...
| Schlagworte: | 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]-ethanone |
| Anwendung: | EIF2AK3?/ PERK inhibitor |
| CAS | 1337531-36-8 |
| MW: | 451.4 D |
ab 48,00 €
Anti-PKR-like Endoplasmic Reticulum Kinase (PERK)
Artikelnummer: 100-401-962
Protein function: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth...
| Schlagworte: | Anti-Pek, Anti-Perk, EC=2.7.11.1, Anti-Eif2ak3, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | ELISA, IHC, IFM, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | mouse |
684,00 €
GSK-2606414
Artikelnummer: SYN-1201-M001
Soluble in DMSO or ethanol. GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC(50) of 0.4nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed Target: PERK , Kinase Group: Other , Substrate: Serine-Threonine
| Schlagworte: | GSK-2606414 |
| Anwendung: | EIF2AK3 / PERK inhibitor |
| CAS | 1337531-36-8 |
| MW: | 451,4 D |
ab 119,00 €
GSK2606414
Artikelnummer: LKT-G7345.1
GSK2606414 is an inhibitor of PERK, or eukaryotic initiation factor 2-? kinase 3 (EIK2AK3, also known as protein kinase R-like endoplasmic reticulum kinase). GSK2606414 exhibits chemotherapeutic benefit, inhibiting growth of tumor xenografts in animal models.
| Anwendung: | EIF2AK3 inhibitor |
| CAS | 1337531-89-1 |
| MW: | 451.44 D |
ab 108,00 €
Anti-PERK
Artikelnummer: NSJ-F50992-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. PERK, a member of the GCN2 subfamily of Ser/Thr protein kinases, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein...
| Schlagworte: | Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Human EIF2AK3 / PERK ELISA Kit
Artikelnummer: G-HUFI01038.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Anti-EIF2AK3 / PERK
Artikelnummer: NSJ-RQ4206
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene. The protein encoded by this gene phosphorylates the alpha...
| Schlagworte: | Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | WB, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Anti-PERK
Artikelnummer: E-AB-32546.120
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the...
| Schlagworte: | Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum... |
| Anwendung: | WB, IHC (paraffin), IF, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 71,00 €